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Biomedical and Life Sciences

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  1. The yeast cell wall is constantly remodeled to enable cell growth and division. In this study, we describe a novel type of cell wall modification. We report that the drug amiodarone induces rapid channel forma...

    Authors: Tatyana S. Kalebina, Sviatoslav S. Sokolov, Irina O. Selyakh, Darya P. Vanichkina and Fedor F. Severin
    Citation: SpringerPlus 2015 4:453
  2. Human immunodeficiency virus-1 (HIV-1) which causes acquired immune deficiency syndrome (AIDS), by infecting CD4+ immune cells and hence weakening the host defense mechanism till death, is one of the major factor...

    Authors: Deepak Bharti, Ashish Kumar, Ranjeet Singh Mahla, Sushil Kumar, Harshad Ingle, Tushar Yadav, Anamika Mishra, Ashwin Ashok Raut and Himanshu Kumar
    Citation: SpringerPlus 2015 4:451
  3. Clinical trials and epidemiological evidence have shown that combined estrogen/progestin hormone replacement therapy, but not estrogen therapy alone, increases breast cancer risk in post-menopausal women. Pre...

    Authors: Matthew T. Cook, Yayun Liang, Cynthia Besch-Williford, Sandy Goyette, Benford Mafuvadze and Salman M. Hyder
    Citation: SpringerPlus 2015 4:444
  4. Long-term parenteral nutrition (PN) can induce intestinal atrophy, leading to a loss of epithelial integrity in the small intestines. This change may alter the intestinal permeability of vancomycin (VCM), a no...

    Authors: Keizo Fukushima, Akira Okada, Yoriko Hayashi, Hideki Ichikawa, Asako Nishimura, Nobuhito Shibata and Nobuyuki Sugioka
    Citation: SpringerPlus 2015 4:442
  5. A 90-day feeding trial was conducted to evaluate the effects of formic acid (FA) and astaxanthin (AX) on growth, survival, immune parameters, and tolerance to Vibrio infection in Pacific white shrimp. The study w...

    Authors: Niti Chuchird, Phitsanu Rorkwiree and Tirawat Rairat
    Citation: SpringerPlus 2015 4:440
  6. Exposure to arsenic in individuals has been found to be associated with immune related problems. In earlier studies, we have demonstrated that amla protects against arsenic induced oxidative stress and apoptos...

    Authors: Manish K. Singh, Suraj Singh Yadav, Rajesh Singh Yadav, Abhishek Chauhan, Devendra Katiyar and Sanjay Khattri
    Citation: SpringerPlus 2015 4:438
  7. Epilepsy demands a major burden at global levels. Worldwide, about 1% of people suffer epilepsy and 30% of them (0.3%) are anticonvulsants resistant. Among them, some children epilepsies are peculiarly difficu...

    Authors: Ricardo Zavala-Yoé, Ricardo Ramírez-Mendoza and Luz M Cordero
    Citation: SpringerPlus 2015 4:437
  8. Hypertrophy (H) is an adaptive response of the heart to a hemodynamic overload. Severe left ventricular (LV) volume overload (VO) from valve regurgitations (aortic (AR) or mitral regurgitation) leads to eccent...

    Authors: Marie-Claude Drolet, Vincent Desbiens-Brassard, Elise Roussel, Veronique Tu, Jacques Couet and Marie Arsenault
    Citation: SpringerPlus 2015 4:435
  9. Onion thrips (Thrips tabaci Lindeman (Thysanoptera: Thripidae)) can be a pest in organic onion production on Prince Edward Island. This study was to examine the effect of planting time and variety on infestation ...

    Authors: Suzanne Blatt, Andrew Ryan, Shelley Adams and Joanne Driscoll
    Citation: SpringerPlus 2015 4:430
  10. The mature root system is a vital plant organ, which is critical to plant performance. Commercial maize (Zea mays L.) breeding has resulted in a steady increase in plant performance over time, along with noticeab...

    Authors: Andrew L Hauck, Joana Novais, Tony E Grift and Martin O Bohn
    Citation: SpringerPlus 2015 4:424
  11. This study aimed to determine the specific characterization of regional storage fat in the upper limb as compared to the lower limb of young healthy adults. The regional storage fat and skeletal muscle in uppe...

    Authors: Junichiro Yamauchi, Toshiyuki Kurihara, Maki Yoshikawa, Sadayoshi Taguchi and Takeshi Hashimoto
    Citation: SpringerPlus 2015 4:402
  12. Twelve lactating cattle × yak hybrids (B. taurus × B. grunniens) were investigated on five experimental pastures (Sites 1–5), following an up- and downward transhumance route (3,200, 4,000, 4,500, 4,000 and 2,600...

    Authors: Shanker R Barsila, Naba R Devkota, Michael Kreuzer and Svenja Marquardt
    Citation: SpringerPlus 2015 4:398
  13. Nuclear genome size, as measured by flow cytometry with propidium iodide, was used to investigate the relationships within the genus Gagea (Liliaceae), mainly from the Netherlands. The basic chromosome number for...

    Authors: B J M Zonneveld, B te Linde and L-J van den Berg
    Citation: SpringerPlus 2015 4:395
  14. ‘Ice Mile’ swimming is a new discipline in open-water swimming introduced in 2009. This case study investigated changes in body core temperature during preparation for and completion of two official ‘Ice Miles...

    Authors: Beat Knechtle, Thomas Rosemann and Christoph A Rüst
    Citation: SpringerPlus 2015 4:394
  15. Halomonas smyrnensis AAD6T is a gram negative, aerobic, and moderately halophilic bacterium, and is known to produce high levels of levan with many potential uses in foods, feeds, cosmeti...

    Authors: Elif Diken, Tugba Ozer, Muzaffer Arikan, Zeliha Emrence, Ebru Toksoy Oner, Duran Ustek and Kazim Yalcin Arga
    Citation: SpringerPlus 2015 4:393
  16. The search for new antimicrobial compounds able to overcome the global issue of microbial resistance to antibiotics is a priority worldwide. Moreover, several commensal microorganisms have been increasingly as...

    Authors: Celso Martins, Vanessa G Correia, Ana Aguiar-Ricardo, Ângela Cunha and Maria Guilhermina M Moutinho
    Citation: SpringerPlus 2015 4:382
  17. We investigated the effect of Katsura-uri (Japanese pickling melon; Cucumis melo var. conomon) on energy metabolism during exercise in human and animal studies.

    Authors: Wataru Aoi, Kazuya Takeda, Azusa Sasaki, Yuki Hasegawa, Yasushi Nakamura, Eun Young Park, Kenji Sato, Masayo Iwasa, Airi Nakayama, Mizuki Minamikawa, Yukiko Kobayashi, Koji Shirota and Noboru Suetome
    Citation: SpringerPlus 2015 4:377

    The Erratum to this article has been published in SpringerPlus 2015 4:530

  18. Porcine bocavirus is classified within the genus Bocaparvovirus, family Parvoviridae. Unlike other parvoviruses, the members of genus Bocaparvovirus (bocaparvoviruses) encode an additional open reading frame (NP1...

    Authors: Sung J Yoo, Sun Young Sunwoo, Seong Sik Ko, Sang H Je, Dong Uk Lee and Young S Lyoo
    Citation: SpringerPlus 2015 4:370
  19. This study observed influenza activity between June 2009 and July 2014 in Thailand, a country in the Northern hemisphere with a tropical climate, and compared the results to activity in the United States (US) ...

    Authors: Slinporn Prachayangprecha, Preeyaporn Vichaiwattana, Sumeth Korkong, Joshua A Felber and Yong Poovorawan
    Citation: SpringerPlus 2015 4:356
  20. This study determined the effects of acute treatment with morphine on the expression of the Oprm1, Oprk1, and Oprd1 genes (which encode μ, κ, and δ receptors, respectively) in the striatum, hypothalamus, and peri...

    Authors: Wesley Soares Cruz, Lucas Assis Pereira, Luana Carvalho Cezar, Rosana Camarini, Luciano Freitas Felicio, Maria Martha Bernardi and Elizabeth Teodorov
    Citation: SpringerPlus 2015 4:355
  21. Multi-domain proteins form the majority of proteins in eukaryotes. During their formation by tandem duplication or gene fusion, new interactions between domains may arise as a result of the structurally-forced...

    Authors: Joana Projecto-Garcia, Didier Jollivet, Jean Mary, François H Lallier, Stephen W Schaeffer and Stéphane Hourdez
    Citation: SpringerPlus 2015 4:354
  22. Arousal theory as discussed within the present paper refers to those mechanisms and neural systems involved in central nervous system activation and more specifically the systems involved in cortical activatio...

    Authors: Clinton S Comer, Patti Kelly Harrison and David W Harrison
    Citation: SpringerPlus 2015 4:345
  23. A wide inventory of molecular markers is nowadays available for individual fingerprinting. Microsatellites, or simple sequence repeats (SSRs), play a relevant role due to their relatively ease of use, their ab...

    Authors: Maria Teresa Dettori, Sabrina Micali, Jessica Giovinazzi, Simone Scalabrin, Ignazio Verde and Guido Cipriani
    Citation: SpringerPlus 2015 4:337
  24. Open-water ultra-distance swimming has a long history where the ‘English Channel’ (~33 km) was crossed in 1875 for the first time. Nowadays, the three most challenging open-water swims worldwide are the 21-mil...

    Authors: Beat Knechtle, Thomas Rosemann and Christoph Alexander Rüst
    Citation: SpringerPlus 2015 4:332
  25. It has been suggested that people with Ehlers–Danlos syndrome (EDS), or other similar connective tissue disorders, may have proprioceptive impairments, the reason for which is still unknown. We recently found ...

    Authors: Holly A Clayton, Stephanie A H Jones and Denise Y P Henriques
    Citation: SpringerPlus 2015 4:323
  26. Information on the effect of long-term management on soil nutrients and chemical properties is scanty. We examined the 30-year effect of tillage frequency and cropping sequence combination on dryland soil Olse...

    Authors: Upendra M Sainju, Brett L Allen, Thecan Caesar-TonThat and Andrew W Lenssen
    Citation: SpringerPlus 2015 4:320
  27. Ethanolic extract of Euryale ferox salisb. (EFx) may have an effect on the activity of hepatic antioxidant enzymes, glycemic control and lipid profile and histopathology of pancreas, liver and kidney of streptozo...

    Authors: Danish Ahmed, Vikas Kumar, Amita Verma, Girija Shankar Shukla and Manju Sharma
    Citation: SpringerPlus 2015 4:315
  28. Bacterial bloodstream infections are a major public health problem, which leads to high morbidity and mortality of patients. On time diagnosis and appropriate medication will be the best way to save the lives ...

    Authors: Araya Gebreyesus Wasihun, Letemichael Negash Wlekidan, Senay Aregawi Gebremariam, Tsehaye Asmelash Dejene, Abadi Luel Welderufael, Tadesse Dejenie Haile and Saravanan Muthupandian
    Citation: SpringerPlus 2015 4:314
  29. Methylglyoxal (MG) can cause protein glycation, resulting in cell damage and dysfunction. Accumulation of MG and its downstream metabolite N ε-(carboxyethyl)lysine (CEL) has been identified in sev...

    Authors: Chu-Kuang Chou, Shih-Ming Chen, Yi-Chieh Li, Tzu-Chuan Huang and Jen-Ai Lee
    Citation: SpringerPlus 2015 4:312
  30. In Arabidopsis thaliana, significant efforts to determine the effect of naturally occurring variation between phenotypically divergent accessions on different biotic or abiotic stresses are underway. Although it ...

    Authors: Md Motaher Hossain and Farjana Sultana
    Citation: SpringerPlus 2015 4:296
  31. Esophageal cancer is one of the world’s top ten cancers. Its incidence, especially in the form of squamous cell carcinoma, is very high in some Asian regions including Kashmir. Jammu Kashmir and Ladakh are thr...

    Authors: Beenish Iqbal, Idrees Ayoub Shah, Gulzar Ahmad Bhat, Arshid Bashir Bhat, Rumaisa Rafiq, Sumaiya Nabi, Reza Malekhzadeh, Christian C Abnet, Paolo Boffetta, Mazda Jenab and Nazir Ahmad Dar
    Citation: SpringerPlus 2015 4:287
  32. Pseudoangiomatous stromal hyperplasia (PASH) is a benign lesion often observed in parts of the mammary stroma in a variety of breast diseases. It is characterized by stromal myofibroblastic proliferation that ...

    Authors: Akiko Mizutou, Kazutaka Nakashima and Takuya Moriya
    Citation: SpringerPlus 2015 4:282
  33. To better understand the relative importance of the multi-purpose functions of small ruminants for their urban owners and related breeding practices including selection criteria, we undertook a comparative ana...

    Authors: Luc Hippolyte Dossa, Mamadou Sangaré, Andreas Buerkert and Eva Schlecht
    Citation: SpringerPlus 2015 4:281
  34. Induction of oxidative stress by drugs and other xenobiotics is an important mechanism of cytotoxicity. However, in vitro studies on the relationship between oxidative stress and cytotoxicity in cultured cells...

    Authors: Jessica L Kelts, James J Cali, Sarah J Duellman and John Shultz
    Citation: SpringerPlus 2015 4:269
  35. The aim of our study was to look for alternative predictive biomarkers for breast cancer management in limited resource setup. A comprehensive analysis of circulating cell-free DNA (CCFD) in serum at baseline ...

    Authors: Sobuhi Iqbal, Sreenivas Vishnubhatla, Vinod Raina, Surabhi Sharma, Ajay Gogia, Suryanarayana S V Deo, Sandeep Mathur and Nutan Kumar Shukla
    Citation: SpringerPlus 2015 4:265
  36. The use of positive selectable marker genes is widespread in plant genetic transformation allowing transgenic cells to grow while repressing non-transgenic cells. Negative selectable markers, on the contrary, ...

    Authors: Maria Luiza Peixoto de Oliveira, Ed Stover and James G Thomson
    Citation: SpringerPlus 2015 4:264