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  1. The oral pre-administration of proline, one on the non-essential amino acids, has been shown to effectively protect the liver from D-galactosamine (GalN)-induced liver injury and dramatically improve the survi...

    Authors: Yoko Obayashi, Harumi Arisaka, Shintaro Yoshida, Masato Mori and Michio Takahashi
    Citation: SpringerPlus 2015 4:199
  2. The incidence of malignancies in kidney transplant recipients is increasing. Breast cancer is a common malignancy after kidney transplantation and can be more aggressive in kidney transplant recipients than in...

    Authors: Taigo Kato, Yoichi Kakuta, Kazuaki Yamanaka, Masayoshi Okumi, Toyofumi Abe, Ryoichi Imamura, Naotsugu Ichimaru, Shiro Takahara and Norio Nonomura
    Citation: SpringerPlus 2015 4:196
  3. There is growing evidence supporting the role of inflammation in aneurysmal subarachnoid hemorrhage (aSAH) pathophysiology and it is of great interest to elucidate which immune mechanisms are involved.

    Authors: Leandro Moraes, Sofía Grille, Paula Morelli, Rafael Mila, Natalia Trias, Andreína Brugnini, Natalia LLuberas, Alberto Biestro and Daniela Lens
    Citation: SpringerPlus 2015 4:195
  4. An innovative approach, called associated liver partition and portal vein ligation for staged hepatectomy(ALPPS), has made possible a marked increase in future liver remnant (FLR) volume over a short period of...

    Authors: Yusuke Ome, Kazuyuki Kawamoto, Tae Bum Park, Tadashi Ito and Keizo Ogasahara
    Citation: SpringerPlus 2015 4:194
  5. Bilateral Breast Carcinoma (BBC) is a rare entity with incidence of synchronous carcinoma being 2-5% of all breast malignancies, which is much less than metachronous carcinoma. Synchronicity/ metachronicity ar...

    Authors: Vijay Kumar Shankarrao Kappikeri and Akshay Mahesh Kriplani
    Citation: SpringerPlus 2015 4:193
  6. To discuss the feasibility of low-dose whole-pancreas imaging utilizing 640-slice dynamic volume CT.80 patients (40 cases of normal pancreas and 40 patients supposed of having pancreatic carcinoma or focal pan...

    Authors: Zhengwu Tan, Qi Miao, Xiaoling Li, Ke Ren, Yu Zhao, Li Zhao, Xuedan Li, Yi Liu, Ruimei Chai and Ke Xu
    Citation: SpringerPlus 2015 4:192
  7. Recent studies concerning species of land snails have revealed that the shell morphometrics can provide evidence of the differentiation among populations. In many cases, the morphologic analysis combined with ...

    Authors: Camilla Medeiros, Roberta Lima Caldeira, Cristiane Lafetá Furtado Mendonça, Omar dos Santos Carvalho and Sthefane D’ávila
    Citation: SpringerPlus 2015 4:191
  8. Dictyostelium harbors multiple expansin-like genes with generally unknown functions. Thus, we analyzed the expansin-like 3 (expL3) gene and found that its expression was reduced in a null mutant ...

    Authors: Takefumi Kawata, Yuri Nakamura, Yukika Saga, Yumi Iwade, Megumi Ishikawa, Aya Sakurai and Nao Shimada
    Citation: SpringerPlus 2015 4:190
  9. Two genomic fragments (5,662 and 1,269 nt in size, GenBank accession no. JQ756122 and JQ756123, respectively) of novel, positive-strand RNA viruses that infect archaea were first discovered in an acidic hot sp...

    Authors: Hongming Wang, Yongxin Yu, Taigang Liu, Yingjie Pan, Shuling Yan and Yongjie Wang
    Citation: SpringerPlus 2015 4:189
  10. Goats (Capra hircus) are widely distributed in Africa and Asia, and are important to the subsistence and economic livelihoods of many people in these areas. The goat feeding system among rural small holder farmer...

    Authors: Dorothy Kalule Nampanzira, John David Kabasa, Sara Agnes Nalule, Immaculate Nakalembe and John Robert Stephen Tabuti
    Citation: SpringerPlus 2015 4:188
  11. Leprosy is a chronic infectious disease that remains a major challenge to public health in endemic countries. Increasing evidence has highlighted the importance of microbiota for human general health and, as s...

    Authors: Paulo ES Silva, Patrícia S Costa, Marcelo P Ávila, Maria Luíza S Suhadolnik, Mariana P Reis, Ana Paula C Salgado, Mário FR Lima, Edmar Chartone-Souza and Andréa MA Nascimento
    Citation: SpringerPlus 2015 4:187
  12. The immune system and vascular endothelial growth factor (VEGF) may be influential in melanoma behavior. We performed a prospective, exploratory analysis in 10 stage III and 22 stage IV melanoma patients to ob...

    Authors: Nicole Marie Agostino, Christine Saraceni, Hope Kincaid, Wenjing Shi, Wendy Kay Nevala, Svetomir Markovic and Suresh G Nair
    Citation: SpringerPlus 2015 4:186
  13. Knowledge of the network structure of agonistic interactions helps to understand the formation and the development of aggressive behavior. Therefore, video observation data of 149 pigs over three different age...

    Authors: Kathrin Büttner, Katharina Scheffler, Irena Czycholl and Joachim Krieter
    Citation: SpringerPlus 2015 4:185
  14. The aim of this study was to evaluate the influence of stocking density (0.5, 1, 2 and 3 fishL−1) and commercial marine fish diets (diet A, B, C and D) over four months on specific growth rate, condition factor, ...

    Authors: João Chambel, Vera Severiano, Teresa Baptista, Susana Mendes and Rui Pedrosa
    Citation: SpringerPlus 2015 4:183
  15. The newly discovered extracellular death factor (EDF) is a pentapeptide with the sequence NNWNN in Escherichia coli. It was reported that it participated in the cell death process mediated by toxin-antitoxin syst...

    Authors: Zhongyi Yan, Guodong Li, Yanfeng Gao, Wenjie Zhai, Yuanming Qi and Mingxia Zhai
    Citation: SpringerPlus 2015 4:182
  16. The clinical sign of coma is a common feature in critical care medicine. However, little information has been put forth on the correlations between coma and cerebral imaging methods. The purpose of the article...

    Authors: Walter F Haupt, Hans Christian Hansen, Rudolf W C Janzen, Raimund Firsching and Norbert Galldiks
    Citation: SpringerPlus 2015 4:180
  17. LAPTM4B is a newly cloned gene that shows an active role in many solid tumors progression in substantial researches, mainly through the autophage function. Accumulated studies have been conducted to determine ...

    Authors: Ling-Zi Xia, Zhi-Hua Yin, Yang-Wu Ren, Li Shen, Wei Wu, Xue-Lian Li, Peng Guan and Bao-Sen Zhou
    Citation: SpringerPlus 2015 4:179
  18. Epidemiological studies of knee osteoarthritis (OA) have often used a radiographic definition. However, the clinical syndrome of OA is influenced by a broad range of factors in addition to the structural chang...

    Authors: Camille Parsons, Michael Clynes, Holly Syddall, Darshan Jagannath, Anna Litwic, Suzan van der Pas, Cyrus Cooper, Elaine M Dennison and Mark H Edwards
    Citation: SpringerPlus 2015 4:177
  19. OnabotulinumtoxinA (OnabotA) was approved for treatment of chronic migraine (CM) after publication of PREEMPT trials. Thus, we set out to evaluate the efficacy of OnabotA in a series of patients with CM treate...

    Authors: María Isabel Pedraza, Carolina de la Cruz, Marina Ruiz, Luis López-Mesonero, Elena Martínez, Mercedes de Lera and Ángel Luis Guerrero
    Citation: SpringerPlus 2015 4:176
  20. Sheath blight, caused by the pathogenic fungus Rhizoctonia solani Kühn, is one of the most devastating diseases in rice. Breeders have always faced challenges in acquiring reliable and absolute resistance to this...

    Authors: Shailesh Yadav, Ghanta Anuradha, Ravi Ranjan Kumar, Lakshminaryana Reddy Vemireddy, Ravuru Sudhakar, Krishnaveni Donempudi, Durgarani Venkata, Farzana Jabeen, Yamini Kalinati Narasimhan, Balram Marathi and Ebrahimali Abubacker Siddiq
    Citation: SpringerPlus 2015 4:175
  21. It is well known that in mice the extension in lifespan by rapamycin is sexually dimorphic, in that it has a larger effect in females than males. In a previous study we showed that in male C57BL6 mice, rapamyc...

    Authors: Zhen Yu, Bharath Sunchu, Wilson C Fok, Nahla Alshaikh and Viviana I Pérez
    Citation: SpringerPlus 2015 4:174
  22. Adult-onset Still’s disease is a rare systemic inflammatory disorder of unknown aetiology characterized by the classic triad of persistent high spiking fevers, joint pain and a distinctive salmon-colored bumpy...

    Authors: Sergio A Mora Alfonso, Daniel M Cuestas Rodríguez, John D Londoño, Rafael Valle-Oñate and Gerardo Quintana
    Citation: SpringerPlus 2015 4:172
  23. The aim of this study has been to investigate the potential of serum biomarkers used in clinical practice (CEA, CYFRA 21–1, SCC) together with the serum epidermal growth factor receptor (EGFR) and its associat...

    Authors: Elena Yaiza Romero-Ventosa, Sonia Blanco-Prieto, Ana Lourdes González-Piñeiro, Francisco Javier Rodríguez-Berrocal, Guadalupe Piñeiro-Corrales and María Páez de la Cadena
    Citation: SpringerPlus 2015 4:171
  24. Couples HIV Testing and Counseling (CHTC) has been used as an HIV prevention strategy in Africa for over 20 years where the HIV epidemic is largely concentrated among sexually active heterosexuals. In recent y...

    Authors: Rob Stephenson, Catherine Finneran, Tamar Goldenberg, Patricia Coury-Doniger, Theresa E Senn, Marguerite Urban, Ann Schwartz and Patrick Sullivan
    Citation: SpringerPlus 2015 4:169
  25. Tagging of RNases, such as the ribotoxin α-sarcin, with the variable domains of antibodies directed to surface antigens that are selectively expressed on tumor cells endows cellular specificity to their cytoto...

    Authors: Jaime Tomé-Amat, Miriam Olombrada, Javier Ruiz-de-la-Herrán, Eduardo Pérez-Gómez, Clara Andradas, Cristina Sánchez, Leopoldo Martínez, Álvaro Martínez-del-Pozo, José G Gavilanes and Javier Lacadena
    Citation: SpringerPlus 2015 4:168
  26. The purpose of this study is to know clinical factors underlying either a single surgery or repetitive surgeries, required to treat superior oblique muscle palsy. Retrospective review was made on 246 consecut...

    Authors: Kana Aoba, Toshihiko Matsuo, Ichiro Hamasaki and Kayoko Hasebe
    Citation: SpringerPlus 2015 4:166
  27. In view of the rising global problems of environment pollution and degradation, the present process provides a ‘green solution’ to the synthesis of higher esters of lubricant range, more specifically in the ra...

    Authors: Jayati Trivedi, Mounika Aila, Chandra Dutt Sharma, Piyush Gupta and Savita Kaul
    Citation: SpringerPlus 2015 4:165
  28. In this study, MgxCu3-xV2O8 (0 ≤ x ≤ 3) and MgyCu2-yV2O7 (0 ≤ y ≤ 2) compositions were synthesized by the chemical coprecipitation method and characterized by X-ray diffraction, UV–vis-NIR spectroscopy and CIE L*...

    Authors: M A Tena and Santiago García-Granda
    Citation: SpringerPlus 2015 4:163
  29. Neutrophils are one the earliest, crucial innate defenses against innumerable pathogens. Their main microbicidal activities include phagocytosis and degranulation, with many pharmacologically active molecules ...

    Authors: Luis Donis-Maturano, Luvia E Sánchez-Torres, Arturo Cerbulo-Vázquez, Rommel Chacón-Salinas, Gina S García-Romo, Mariana C Orozco-Uribe, Juan C Yam-Puc, Marco A González-Jiménez, Yuriria L Paredes-Vivas, Juana Calderón-Amador, Sergio Estrada-Parra, Iris Estrada-García and Leopoldo Flores-Romo
    Citation: SpringerPlus 2015 4:161
  30. Cortical stimulation plays an important role in the study of epileptic seizures. We present a numerical simulation of stimulation using optogenetic channels expressed by excitatory cells in a mean field model ...

    Authors: Prashanth Selvaraj, Jamie W Sleigh, Heidi E Kirsch and Andrew J Szeri
    Citation: SpringerPlus 2015 4:155
  31. Positron emission tomography with 2-deoxy-2-[18F]fluoro-D-glucose (FDG-PET) has been proven useful for differentiating pancreatic ductal cancer from mass-forming chronic pancreatitis. However, there are particula...

    Authors: Masato Yoshioka, Hiroshi Uchinami, Go Watanabe, Tsutomu Sato, Satoshi Shibata, Makoto Kume, Koichi Ishiyama, Satoshi Takahashi, Manabu Hashimoto and Yuzo Yamamoto
    Citation: SpringerPlus 2015 4:154
  32. Conventional lithography-based VLSI design technology deployed to optimize low-powered-computing and higher scale integration of semiconductor components. However, this downscaling trend confronts serious chal...

    Authors: Ali Newaz Bahar, Sajjad Waheed and Nazir Hossain
    Citation: SpringerPlus 2015 4:153
  33. Platinum-based chemoradiotherapy (CRT) is a standard front-line treatment for locally advanced non-small cell lung cancer (NSCLC). However, no clinical trials have compared the efficacy and toxicity of platinu...

    Authors: Hisao Imai, Kyoichi Kaira, Keita Mori, Akira Ono, Hiroaki Akamatsu, Tetsuhiko Taira, Reiko Yoshino, Hirotsugu Kenmotsu, Jun-ichi Saitoh, Hideyuki Harada, Tateaki Naito, Haruyasu Murakami, Yoshio Tomizawa, Masana Matsuura, Ryusei Saito, Takashi Nakajima…
    Citation: SpringerPlus 2015 4:152
  34. We expressed the heat-labile enterotoxin B (LTB) subunit from enterotoxigenic Escherichia coli and the cholera toxin B (CTB) subunit from Vibrio cholerae under the control of the rice (Oryza sativa) globulin (Glb

    Authors: Ho Seob Soh, Ha Young Chung, Hyun Ho Lee, Hemavathi Ajjappala, Kyoungok Jang, Jong-Hwa Park, Joon-Soo Sim, Gee Young Lee, Hyun Ju Lee, Young Hee Han, Jae Wook Lim, Inchan Choi, In Sik Chung and Bum-Soo Hahn
    Citation: SpringerPlus 2015 4:148