Aly H, Gottlieb P (2009) The honeymoon phase: intersection of metabolism and immunology. Curr Opin Endocrinol Diabetes Obes 16:286–292. doi:10.1097/MED.0b013e32832e0693
Article
Google Scholar
Antvorskov JC, Fundova P, Buschard K, Funda DP (2013) Dietary gluten alters the balance of pro-inflammatory and anti-inflammatory cytokines in T cells of BALB/c mice. Immunology 138:23–33. doi:10.1111/imm.12007
Article
Google Scholar
Arora SK, McFarlane SI (2005) The case for low carbohydrate diets in diabetes management. Nutr Metab 2:16
Article
Google Scholar
Besser REJ, Shields BM, Casas R et al (2013) Lessons from the mixed-meal tolerance test: use of 90-minute and fasting C-peptide in pediatric diabetes. Diabetes Care 36:195–201. doi:10.2337/dc12-0836
Article
Google Scholar
Biltoft-Jensen A, Hjorth MF, Trolle E et al (2013) Comparison of estimated energy intake using web-based dietary assessment software with accelerometer-determined energy expenditure in children. Food Nutr Res. doi:10.3402/fnr.v57i0.21434
Google Scholar
Bosi E, Molteni L, Radaelli MG et al (2006) Increased intestinal permeability precedes clinical onset of type 1 diabetes. Diabetologia 49:2824–2827. doi:10.1007/s00125-006-0465-3
Article
Google Scholar
Brown RJ, Rother KI (2008) Effects of beta-cell rest on beta-cell function: a review of clinical and preclinical data. Pediatr Diabetes 9:14–22. doi:10.1111/j.1399-5448.2007.00272.x
Article
Google Scholar
Carlsson E, Frostell A, Ludvigsson J, Faresjö M (2014) Psychological stress in children may alter the immune response. J Immunol 192:2071–2081. doi:10.4049/jimmunol.1301713
Article
Google Scholar
Cleary PA, Dahms W, Goldstein D, Malone J, Tamborlane WV (2001) Beneficial effects of intensive therapy of diabetes during adolescence: outcomes after the conclusion of the Diabetes Control and Complications Trial (DCCT). J Pediatr 139:804–812. doi:10.1067/mpd.2001.118887
Article
Google Scholar
Cosnes J, Cellier C, Viola S et al (2008) Incidence of autoimmune diseases in celiac disease: protective effect of the gluten-free diet. Clin Gastroenterol Hepatol 6:753–758. doi:10.1016/j.cgh.2007.12.022
Article
Google Scholar
Dall M, Calloe K, Haupt-Jorgensen M et al (2013) Gliadin fragments and a specific gliadin 33-mer peptide close KATP channels and induce insulin secretion in INS-1E cells and rat islets of Langerhans. PLoS ONE 8:1–10. doi:10.1371/journal.pone.0066474
Article
Google Scholar
Drago S, El Asmar R, Di Pierro M et al (2006) Gliadin, zonulin and gut permeability: effects on celiac and non-celiac intestinal mucosa and intestinal cell lines. Scand J Gastroenterol 41:408–419. doi:10.1080/00365520500235334
Article
Google Scholar
Due P, de Beaufort C, Damsgaard MT et al (2013) Do eating behaviors in the general population account for country variance in glycemic control among adolescents with diabetes: the Hvidoere Study Group and the Health Behaviour in School-Aged Children study. Pediatr Diabetes 14:554–561. doi:10.1111/pedi.12038
Article
Google Scholar
Ejsing-Duun M, Josephsen J, Aasted B et al (2008) Dietary gluten reduces the number of intestinal regulatory T cells in mice. Scand J Immunol 67:553–559. doi:10.1111/j.1365-3083.2008.02104.x
Article
Google Scholar
Fuchtenbusch M, Ziegler A-G, Hummel M (2004) Elimination of dietary gluten and development of type 1 diabetes in high risk subjects. Rev Diabet Stud 1:39–41. doi:10.1900/RDS.2004.1.39
Article
Google Scholar
Garcia-Webb DP, Bonser A, Welborn TA (1982) Correlation between fasting serum C-peptide and beta cell insulin secretory capacity in diabetes mellitus. Diabetologia 22:296. doi:10.1007/BF00281310
Article
Google Scholar
Greenbaum CJ, Mandrup-Poulsen T, McGee PF et al (2008) Mixed-meal tolerance test versus glucagon stimulation test for the assessment of beta-cell function in therapeutic trials in type 1 diabetes. Diabetes Care 31:1966–1971. doi:10.2337/dc07-2451
Article
Google Scholar
Hansen CHF, Krych L, Nielsen DS et al (2012) Early life treatment with vancomycin propagates Akkermansia muciniphila and reduces diabetes incidence in the NOD mouse. Diabetologia 55:2285–2294. doi:10.1007/s00125-012-2564-7
Article
Google Scholar
Hummel M, Bonifacio E, Naserke HE, Ziegler AG (2002) Elimination of dietary gluten does not reduce titers of type 1 diabetes-associated autoantibodies in high-risk subjects. Diabetes Care 25:1111–1116. doi:10.2337/diacare.25.7.1111
Article
Google Scholar
Keymeulen B, Walter M, Mathieu C et al (2010) Four-year metabolic outcome of a randomised controlled CD3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual beta cell mass. Diabetologia 53:614–623. doi:10.1007/s00125-009-1644-9
Article
Google Scholar
Lachin JM, McGee P, Palmer JP (2014) Impact of C-peptide preservation on metabolic and clinical outcomes in the diabetes control and complications trial. Diabetes 63:739–748. doi:10.2337/db13-0881
Article
Google Scholar
Larsen J, Dall M, Antvorskov JC et al (2014) Dietary gluten increases natural killer cell cytotoxicity and cytokine secretion. Eur J Immunol 44(10):3056–3067. doi:10.1002/eji.201344264
Article
Google Scholar
Ludvigsson J (2007) Immune intervention at diagnosis—should we treat children to preserve beta-cell function? Pediatr Diabetes 8:34–39
Article
Google Scholar
Ludvigsson J, Krisky D, Casas R et al (2012) GAD65 antigen therapy in recently diagnosed type 1 diabetes mellitus. N Engl J Med 366:433–442. doi:10.1056/NEJMoa1107096
Article
Google Scholar
Madsbad S, Alberti KG, Binder C et al (1979) Role of residual insulin secretion in protecting against ketoacidosis in insulin-dependent diabetes. Br Med J 2:1257–1259
Article
Google Scholar
Madsbad S, Lauritzen E, Faber OK, Binder C (1986) The effect of residual beta-cell function on the development of diabetic retinopathy. Diabet Med J Br Diabet Assoc 3:42–45
Article
Google Scholar
Marietta EV, Gomez AM, Yeoman C et al (2013) Low incidence of spontaneous type 1 diabetes in non-obese diabetic mice raised on gluten-free diets is associated with changes in the intestinal microbiome. PLoS ONE 8:1–9. doi:10.1371/journal.pone.0078687
Article
Google Scholar
Max Andersen ML, Nielsen LB, Svensson J et al (2014a) Disease progression among 446 children with newly diagnosed type 1 diabetes located in Scandinavia, Europe, and North America during the last 27 yr. Pediatr Diabetes 15(5):345–354. doi:10.1111/pedi.12098
Article
Google Scholar
Max Andersen MLC, Hougaard P, Pörksen S et al (2014b) Partial remission definition: validation based on the insulin dose-adjusted HbA1c (IDAA1C) in 129 Danish children with new-onset type 1 diabetes. Pediatr Diabetes 15:469–476. doi:10.1111/pedi.12208
Article
Google Scholar
Meier JJ, Butler AE, Saisho Y et al (2008) Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans. Diabetes 57:1584–1594. doi:10.2337/db07-1369
Article
Google Scholar
Mortensen HB, Hougaard P, Swift P et al (2009) New definition for the partial remission period in children and adolescents with type 1 diabetes. Diabetes Care 32:1384–1390. doi:10.2337/dc08-1987
Article
Google Scholar
Norris JM, Barriga K, Klingensmith G et al (2003) Timing of initial cereal exposure in infancy and risk of islet autoimmunity. JAMA 290:1713–1720. doi:10.1001/jama.290.13.1713
Article
Google Scholar
Olsen BS, Sjølie AK, Hougaard P et al (2004) The significance of the prepubertal diabetes duration for the development of retinopathy and nephropathy in patients with type 1 diabetes. J Diabetes Complic 18:160–164. doi:10.1016/S1056-8727(03)00073-4
Article
Google Scholar
Palmer JP, Fleming GA, Greenbaum CJ et al (2004) C-peptide is the appropriate outcome measure for type 1 diabetes clinical trials to preserve β-cell function report of an ADA workshop, 21–22 October 2001. Diabetes 53:250–264. doi:10.2337/diabetes.53.1.250
Article
Google Scholar
Pastore M-R, Bazzigaluppi E, Belloni C et al (2003) Six months of gluten-free diet do not influence autoantibody titers, but improve insulin secretion in subjects at high risk for type 1 diabetes. J Clin Endocrinol Metab 88:162–165. doi:10.1210/jc.2002-021177
Article
Google Scholar
Pedersen A, Fagt S, Groth M (2010) Danskernes kostvaner 2003–2008
Pescovitz MD, Greenbaum CJ, Bundy B et al (2014) B-lymphocyte depletion with rituximab and β-cell function: two-year results. Diabetes Care 37:453–459. doi:10.2337/dc13-0626
Article
Google Scholar
Rovner AJ, Nansel TR, Gellar L (2009) The effect of a low-glycemic diet vs a standard diet on blood glucose levels and macronutrient intake in children with type 1 diabetes. J Am Diet Assoc 109:303–307. doi:10.1016/j.jada.2008.10.047
Article
Google Scholar
Schloot NC, Hanifi-Moghaddam P, Aabenhus-Andersen N et al (2007) Association of immune mediators at diagnosis of Type 1 diabetes with later clinical remission. Diabet Med J Br Diabet Assoc 24:512–520. doi:10.1111/j.1464-5491.2007.02096.x
Article
Google Scholar
Sildorf SM, Fredheim S, Svensson J, Buschard K (2012) Remission without insulin therapy on gluten-free diet in a 6-year old boy with type 1 diabetes mellitus. BMJ Case Rep. doi:10.1136/bcr.02.2012.5878
Google Scholar
Sildorf SM, Hertel NT, Thomsen J et al (2016) Treatment intensification without improved HbA1c levels in children and adolescents with type 1 diabetes mellitus. Diabet Med. 33(4):515–522. doi:10.1111/dme.12900
Article
Google Scholar
Sjöberg S, Gunnarsson R, Gjötterberg M et al (1987) Residual insulin production, glycaemic control and prevalence of microvascular lesions and polyneuropathy in long-term Type 1 (insulin-dependent) diabetes mellitus. Diabetologia 30:208–213. doi:10.1007/BF00270417
Article
Google Scholar
Steffes MW, Sibley S, Jackson M, Thomas W (2003) Beta-cell function and the development of diabetes-related complications in the diabetes control and complications trial. Diabetes Care 26:832–836. doi:10.2337/diacare.26.3.832
Article
Google Scholar
Viljamaa M, Kaukinen K, Huhtala H et al (2005) Coeliac disease, autoimmune diseases and gluten exposure. Scand J Gastroenterol 40:437–443. doi:10.1080/00365520510012181
Article
Google Scholar
Ziegler AG, Schmid S, Huber D et al (2003) Early infant feeding and risk of developing type 1 diabetes-associated autoantibodies. JAMA 290:1721–1728. doi:10.1001/jama.290.13.1721
Article
Google Scholar