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  1. New treatments with novel mechanisms of action and non-overlapping toxicities are needed for patients with metastatic breast cancer. Etirinotecan pegol (EP) is a long-acting topoisomerase-I inhibitor with a un...

    Authors: Javier Cortés, Hope S. Rugo, Chris Twelves, Ahmad Awada, Edith A. Perez, Seock-Ah Im, Carol Zhao, Ute Hoch, Denise Tomkinson, James Buchanan, Mary Tagliaferri, Alison Hannah and Joyce O’Shaughnessy
    Citation: SpringerPlus 2016 5:1033
  2. A firewall is the most essential component of network perimeter security. Due to human error and the involvement of multiple administrators in configuring firewall rules, there exist common anomalies in firewa...

    Authors: Ravi Kiran Varma Penmatsa, Valli Kumari Vatsavayi and Srinivas Kumar Samayamantula
    Citation: SpringerPlus 2016 5:1032
  3. There is a growing recognition of the need to examine religiousness and conduct research on its influence on acculturation and adjustment among ethnic minorities (Güngör et al. in Int J Behav Dev 36:367–373, 2012

    Authors: Radosveta Dimitrova and Arzu Aydinli-Karakulak
    Citation: SpringerPlus 2016 5:1024
  4. Glutamate (Glu) plays various roles directly or through conversions to other amino acids in intracellular metabolisms such as energy source for enterocytes and precursor for nucleic acids. In this study, we ex...

    Authors: Chika Yoshida, Mayumi Maekawa, Makoto Bannai and Takeshi Yamamoto
    Citation: SpringerPlus 2016 5:1021
  5. Improving the understanding of climate change awareness is one of the top priorities in climate change research. While the African continent is among the regions with the highest vulnerability to climate chang...

    Authors: Chadwick O. Ajuang, Paul O. Abuom, Esna K. Bosire, Gabriel O. Dida and Douglas N. Anyona
    Citation: SpringerPlus 2016 5:1015
  6. Authors: Gisela L. G. Menezes, Bertine L. Stehouwer, Dennis W. J. Klomp, Tijl A. van der Velden, Maurice A. A. J. van den Bosch, Floortje M. Knuttel, Vincent O. Boer, Wybe J. M. van der Kemp, Peter R. Luijten and Wouter B. Veldhuis
    Citation: SpringerPlus 2016 5:1012

    The original article was published in SpringerPlus 2016 5:13

  7. The paper seeks to establish whether or not remittances promoted financial developments and explore the traceable causality between remittances and financial developments in some countries in Africa. We examin...

    Authors: Nana Kwasi Karikari, Sam Mensah and Simon K. Harvey
    Citation: SpringerPlus 2016 5:1011
  8. To determine frequency of routine radiological staging of breast cancer patients diagnosed in a German Breast Cancer Screening Center from 2007 to 2014, the incidence and consequences of distant metastases det...

    Authors: Peter Rusch, Oliver Hoffmann, Anna-L. Stickelmann, Stephan Böhmer, Regine Gätje, Karl G. Krüger, Stefan Niesert, Andrea Schmidt and Rainer Kimmig
    Citation: SpringerPlus 2016 5:1010
  9. To improve work ability and health-related quality of life (HRQOL) cancer patients were offered a “Rapid-Return to Work” program. However, several patients did not improve their work status after completing th...

    Authors: Lene Thorsen, Alv A. Dahl, Roy Nystad, Cecilie E. Kiserud, Amy Ø. Geirdal and Sigbjørn Smeland
    Citation: SpringerPlus 2016 5:1009
  10. Vinasses are a residual liquid generated after the production of beverages, such as mezcal and tequila, from agave (Agave L.), sugarcane (Saccharum officinarum L.) or sugar beet (Beta vulgaris L.). These effluent...

    Authors: R. G. Moran-Salazar, A. L. Sanchez-Lizarraga, J. Rodriguez-Campos, G. Davila-Vazquez, E. N. Marino-Marmolejo, L. Dendooven and S. M. Contreras-Ramos
    Citation: SpringerPlus 2016 5:1007
  11. Chronic migraine is a disabling condition that impacts multiple aspects of migraineurs’ lives. Although pharmacological treatments can help to treat the pain associated with migraine headache, chronic migraine...

    Authors: Jieun Lee, Amrita Bhowmick and Amy Wachholtz
    Citation: SpringerPlus 2016 5:1006
  12. This study aimed to compare the efficacy and safety of the newest bipolar vessel sealing system (BVSS; LigaSure™ Small Jaw) to that of conventional technique in axillary dissection.

    Authors: Tomoko Seki, Tetsu Hayashida, Maiko Takahashi, Hiromitsu Jinno and Yuko Kitagawa
    Citation: SpringerPlus 2016 5:1004
  13. Covering approximation spaces are a generalization of equivalence-based rough set theories. In this paper, we will consider twelve types of covering based approximation operators by combining four types of cov...

    Authors: Samira Safari and Mohammad Reza Hooshmandasl
    Citation: SpringerPlus 2016 5:1003
  14. Formal analysis of functional properties of system requirements needs precise descriptions. However, the stakeholders sometimes describe the system with ambiguous, vague or fuzzy terms, hence formal frameworks...

    Authors: Hong Anh Le, Shin Nakajima and Ninh Thuan Truong
    Citation: SpringerPlus 2016 5:1000
  15. Noninvasive markers are needed to identify esophageal varices (EV) in patients with chronic liver disease (CLD). Recently, liver stiffness (LS)-spleen size-to-platelet ratio risk score (LSPS) has been shown to...

    Authors: Soichiro Shibata, Satoru Joshita, Takeji Umemura, Tomoo Yamazaki, Naoyuki Fujimori, Yuki Ichikawa, Michiharu Komatsu, Akihiro Matsumoto and Eiji Tanaka
    Citation: SpringerPlus 2016 5:998
  16. Human Fas ligand extracellular domain has been investigated as an important target protein in the field of medical biotechnology. In a recent study, the author developed an effective method to produce biologic...

    Authors: Michiro Muraki
    Citation: SpringerPlus 2016 5:997
  17. Secure data transfer against the malicious attacks is an important issue in an infrastructure-less independent network called mobile ad-hoc network (MANET). Trust assurance between MANET nodes is the key param...

    Authors: Gayathri Dhananjayan and Janakiraman Subbiah
    Citation: SpringerPlus 2016 5:995
  18. Gluten-free diet has shown promising effects in preventing type 1 diabetes (T1D) in animals as well as beneficial effects on the immune system. Gluten-free diet at diabetes onset may alter the natural course a...

    Authors: Jannet Svensson, Stine Møller Sildorf, Christian B. Pipper, Julie N. Kyvsgaard, Julie Bøjstrup, Flemming M. Pociot, Henrik B. Mortensen and Karsten Buschard
    Citation: SpringerPlus 2016 5:994
  19. Pregnancy after organ transplantation is becoming increasingly common. However, reports of the anesthesia for such patients are rare. Heart transplant recipients are always accompanied with pathophysiological...

    Authors: Xiaofei Qi, Xiaolei Wang, Xiaolei Huang, Chenhong Wang, Yin Gu and Yuantao Li
    Citation: SpringerPlus 2016 5:993
  20. Artemisia scoparia, Artemisia sacrorum and Artemisia giraldii were three dominant Artemisia species which successive grew in the secondary succession on abandoned...

    Authors: Yong Wang, Jing Yu, Pengguo Xia, Shaoxuan He, Ziyun Zhou, Ruilian Han and Zongsuo Liang
    Citation: SpringerPlus 2016 5:992
  21. The purpose of this study was to compare the early or late expression levels of p65, Bcl-2, and type II myosin and the frequency of TUNEL-positive nuclei in the rat masseter muscle after injection of different...

    Authors: Young-Min Moon, Min-Keun Kim, Seong-Gon Kim and Tae-Woo Kim
    Citation: SpringerPlus 2016 5:991
  22. In addition to its role in maintaining organism homeostasis, the immune system also plays a crucial role in the modulation of ovarian function, as it regulates ovarian development, follicular maturation, ovula...

    Authors: Haifeng Ye, Xiaoyan Li, Tuochen Zheng, Xia Liang, Jia Li, Jian Huang, Zezheng Pan and Yuehui Zheng
    Citation: SpringerPlus 2016 5:990
  23. A groupie in a graph is a vertex whose degree is not less than the average degree of its neighbors. Under some mild conditions, we show that the proportion of groupies is very close to 1/2 in multitype random ...

    Authors: Yilun Shang
    Citation: SpringerPlus 2016 5:989
  24. Endometrial cancer is one of the most common malignancies in the female genital tract. Programmed cell death 5 (PDCD5) is a newly identified apoptosis related gene and plays an important role in the developmen...

    Authors: Meng Gao, Wei Gao, Zhanying Wang, Yanping Liu, Yue Li, Chao Wei, Yingshuo Sun, Chun Guo, Lining Zhang, Zengtao Wei and Xiaoyan Wang
    Citation: SpringerPlus 2016 5:988
  25. The extraventricular neurocytoma of the sellar region (EVNSR) is a rare disease, it is difficult to make exact diagnosis of and operate on patients. Retrospectively analysed the clinical manifestations, image...

    Authors: Jie Wang, Dong-Lei Song, Li Deng, Shu-Yan Sun, Chun Liu, De-Shan Gong, Yin Wang and Qi-Wu Xu
    Citation: SpringerPlus 2016 5:987
  26. Rare studies have been performed to trace the mineral elements in Dendrobium officinale. In this study, we aim to trace the mineral elements in D. officinale collected from ten geographical locations in China. IC...

    Authors: Nannan Zhu, Shen Han, Chunning Yang, Jixu Qu, Zhirong Sun, Wenjie Liu and Xiaomin Zhang
    Citation: SpringerPlus 2016 5:979
  27. Postmortem computed tomography (PMCT) has recently become important to clarify the cause of death in forensic medicine. It has also been proven to be useful for in-hospital deaths to a certain extent when inte...

    Authors: Asuka Araki, Noriyoshi Ishikawa, Saki Takami, Nahoko Ishikawa, Chika Amano, Haruo Takeshita and Riruke Maruyama
    Citation: SpringerPlus 2016 5:978
  28. Feeding trials were designed to evaluate the nutritive value of feather meal treated by K6 and K82 keratinase. There were five treatments in feather meal preparation: CFM (non-enzymatically treated feather mea...

    Authors: Warintorn Eaksuree, Akkharadet Prachayakitti, Tewa Upathanpreecha, Rutjawate Taharnklaew, Sunee Nitisinprasert and Suttipun Keawsompong
    Citation: SpringerPlus 2016 5:971
  29. The seasonal abundance of African Invader fly, Bactrocera invadens and the influence of temperature and rainfall on fly catches was determined in two agro ecological zones; moist semi-dec...

    Authors: Charles Amankwa Adzim, Maxwell Kelvin Billah and Kwame Afreh-Nuamah
    Citation: SpringerPlus 2016 5:968
  30. Customizable orthopaedic implants are often needed for patients with primary malignant bone tumors due to unique anatomy or complex mechanical problems. Currently, obtaining customizable orthopaedic implants f...

    Authors: Alexander R. Willis, Joseph A. Ippolito, Francis R. Patterson, Joseph Benevenia and Kathleen S. Beebe
    Citation: SpringerPlus 2016 5:967
  31. Although the photoselective vaporization of the prostate has been considered one of the most promising alternatives for treatment of benign prostatic hyperplasia (BPH), published clinical data with the surgica...

    Authors: Lianjun Li, Bo Hu, Muwen Wang, Peng Sun and Xunbo Jin
    Citation: SpringerPlus 2016 5:308