- Open Access
Mammography screening in less developed countries
© Li and Shao. 2015
Received: 2 October 2015
Accepted: 5 October 2015
Published: 15 October 2015
Less developed countries (LDCs) are struggling with an increasing burden of breast cancer. It is important to identify what interventions might be most effective and feasible in reducing overall breast cancer mortality in a resource constrained settings. Mammography screening (MS) utilized in developed countries cannot be equally applied to LDCs. We provide a summary of the status of existing and past MS program attempts in LDCs, and try to determine the prerequisites under which any developing country is ready to benefit from a MS program. We make the case for a “mixed” portfolio of tools to reduce breast cancer mortality with MS reserved only for those sub-populations that meet the criteria. We hope our review will provide a background for policy makers to apply rigorous criteria before attempting to implement costly MS program and before judiciously evaluating additional competed programs in their countries.
Since 2008, breast cancer incidence has increased by more than 20 % and mortality has risen by 14 % (The International Agency for Research on Cancer (IARC) 2013). In 2012 1.67 million new cancer cases and 0.52 million cancer-related deaths were reported (Ferlay et al. 2013). Of these, 52.9 % of global cases and 62.1 % of breast cancer deaths occurred in less developed countries (LDCs) (CIA-The World Factbook 2014). Breast cancer mortality-to incidence (M/I) ratio for less developed regions is 0.37, compared with 0.20 for more developed regions (Ferlay et al. 2013). Health ministries and health-care systems in LDCs are struggling to respond to the increasing morbidity and mortality from advanced cancers among patients treated in the public system and among the urban poor, rural, remote and indigenous populations (Goss et al. 2013). Several studies have described the current status and challenges of breast cancer facing a number of key LDCs including Brazil, (Lee et al. 2012) Mexico (Chavarri-Guerra et al. 2012) and China (Fan et al. 2014). For all of these countries, mortality is much higher due to low cancer awareness, lack of early detection with concomitant higher stage of disease at presentation, lack of an implemented, effective national screening program and lack of timely access to optimal cancer care, all of which challenges the ability of these LDCs to ameliorate their cancer burden.
Stated by the International Agency for Research on Cancer (IARC) that “an urgent need in cancer control today is to develop effective and affordable approaches to the early detection, diagnosis, and treatment of breast cancer among women living in LDCs” (The International Agency for Research on Cancer (IARC) 2013). Patients with late stage breast cancer associated with more substantial economic burden even in developed countries (DCs), (Remak and Brazil 2004) we believe developing an effective and affordable early detection approach may be the first step for majority LDCs.
Mammography screening programs in selected LDCs and DCs
Year implemented (nationwide)
Khanty-Mansiysky autonomous Region-Yugra
State of Sao Paulo
Whether MS programs should be implemented or not for the goal of down-staging and reduce mortality of breast cancer in LDCs is challenging the notion. Based on their current resource-limited health-care systems, most LDCs believe that “raising breast awareness may be a priority goal, before trying to implement wide spread population-based screening” (Harford 2011). However many LDCs are undergoing significant economic growth and change and have rapidly changing socioeconomic, infrastructure and ethnic changes occurring. It is thus an increasing challenge for all LDCs to gain an understanding of the specific circumstances and criteria in which they would consider launching a MS program. Herein we provide a summary of the status of existing and past MS program attempts in LDCs and try to provide criteria on which this decision can be based.
Methods: search strategy and selection criteria
Medline (OVID), Pubmed and Web of Knowledge databases were searched for the subject headings: “breast neoplasm,” “breast cancer,” “breast,” and “screening” both as single headings and combined, up to December 2013. Reference lists from relevant individual articles were examined for additional relevant articles. Full papers and/or abstracts were reviewed and included to illustrate the current status of mammography screening in LDCs if: (1) Mammography screening and related topics were specifically the topic of the manuscript or emphasized within it; (2) breast cancer screening described in the article referred specifically to women living in LDCs (not including those who live in or immigrated to developed countries); (3) the article (abstract) was published in English between 2002 and December 2013 [literature published subsequent to the published IARC Handbook (The International Agency for Research on Cancer (IARC) 2002) of breast cancer screening in 2002].
The current status of mammography screening in LDCs
Level I: LDCs with evaluable MS programs, nationwide or localized region
Eight LDCs have published results from their nationwide or local MS programs (Fig. 1 shaded in blue). Table 1 compares the relevant criteria used to base the MS program on and the MS guidelines that were in place at the time of the programs. In Russia, (Zakharova 2013) Brazil, (Barreto et al. 2012; Mauad et al. 2011) and Mexico, (Rodriguez-Cuevas et al. 2009) due to large populations and diverse health care systems, MS is delivered in selected localized regions of the countries only, rather than a national MS program. In contrast, Hungary, (Boncz et al. 2013) Croatia, (Stamenic and Strnad 2011) Macedonia (Gershan and Antevska-Grujoska 2011) and Poland (Matkowski and Szynglarewicz 2011) has allowed implementation of nationwide MS programs. Since 2006 Uruguay has a unique mandatory screening program termed “the obligation for working women” (female employees must complete breast screening in order to obtain a “health card” that all workers must have (Arie 2013). Recommended screening age in Russia, Brazil, Mexico, Uruguay and Hungary includes women from age 40 and above, whereas in Croatia and Poland, screening is initiated in women only from age 50. Based upon the available data most countries set an upper age of 69 years, although in Brazil no upper age limit is defined. Screening is generally conducted biennially. Adherence rates vary considerably, it is noteworthy that all programs have adherence rates well below 70 %, a level that is considered necessary to confer a reduction in breast cancer mortality (WHO 2008).
Level II: countries which have conducted studies and/or trials to evaluate the accuracy or cost effectiveness of a MS program
Twelve countries have published pilot studies (Fig. 1 shaded in green), consisting of several sequential MS within a specific relatively resource-rich area within their country. These studies have evaluated several important metrics: overall breast cancer detection rates; early detection rates; difficulties in implementation; strategies to expand adherence rates and; cost analyses aimed at informing policy makers on the importance and feasibility of a nationwide organized MS program. One example is a study from India which found CBE performed annually from age 40 to 60 almost as effective as biennial MS in terms of reduction of breast cancer mortality, while incurring only half the total cost of a MS program, (Okonkwo et al. 2008) suggested that western MS programs may not be cost-effective in LDCs, especially in light of competing health care priorities and economic conditions.
Level III: countries with population-based surveys or questionnaires on breast cancer screening awareness and access to opportunistic mammography
Twenty LDCs (Fig. 1 shaded in orange) have no published studies or trials of MS in their countries. However, population-based surveys of public breast cancer awareness and opportunistic MS have occasionally been conducted. Generally, women in these LDCs were shown to have low breast cancer awareness, and mammography utilization rates were very low. Only 18.75 % of female physicians and 17.24 % of female non-health care personnel had mammogram in Iran (Kadivar et al. 2012). One survey in a very low resource area of South Africa reported that “no woman had ever had a mammogram” (Maree et al. 2013).
Level IV: countries with no MS data reported
The remaining LDCs (shaded in white) have not reported any study related to the use of MS.
We also found that varying recommendations and/or guidelines related to mammography are frequently issued by governments in LDCs but with no involvement of ministries of health and no plan for guaranteeing implementation or monitoring of quality control or compliance. Up to now, opportunistic MS in some countries such as Brazil and Mexico do not have any information or databases to understand what has been really going on. Some countries have voiced the intent to launch preventative “screening mammography” programs, but in reality they frequently are referring to “diagnostic mammogram programs”, frequently involving a mammogram either after an opportunistic mammogram has been read as suspicious or after women have experienced symptoms suspicious of breast cancer (National Breast Cancer Foundation 2014). Thus inappropriate attempts to implement such a program in a resource constrained country may lead to disappointing results and contentious use of health care budgets (Tiezzi 2013).
There are no existing methods to evaluate whether a LDC is qualified to have a MS program, Breast Health Global Initiative (BHGI) has proposed stratified guidelines for early detection in resource constrained countries and true MS programs be reserved for “enhanced” and “maximal” resourced countries (Anderson et al. 2011; Yip et al. 2008). In this manuscript we summarize certain prerequisites which must be met for a LDC to consider launching a MS program with a view to reducing national breast cancer specific mortality.
Criteria required for implementation of a MS program in LDCs
Criteria required for implementation of a mammography screening program in LDCs
Breast cancer prevalence, incidence and mortality rates
Sensitivity and specificity to mammography
Socioeconomic and educational level
Mammogram equipment (quantity and quality)
Age of initiation (40 or 50)
End age (69 or >70)
Frequency (once every 1, 2, 3 years)
View (single or double)
Technique (digital or film)
Review method (1 or 2 radiologists)
Combine BSE and/or CBE
Combine other image
Short term outcome
Mortality deduction rate
False Positive rate
Methods of CEA
Crosswise and longitudinal comparison
The first step is defining an appropriate “target population,” a group who will have substantial net benefit from MS (Quanstrum and Hayward 2010). Target populations differ both between and within countries mainly depending on: breast cancer burden and life expectancy; sensitivity and specificity of mammography; socioeconomic and educational level.
Breast cancer burden and demographics of selected countries
5-year prevalence proportion per 100,000
Female population % of total
Population density people/km2
Life expectancy at birth, female years
1,350,695,000 (48.2 %)
1,236,686,732 (48.3 %)
198,656,019 (50.8 %)
143,533,000 (53.8 %)
80,721,874 (49.8 %)
37,195,349 (49.8 %)
313,914,040 (50.8 %)
63,227,526 (50.8 %)
34,880,491 (50.4 %)
No data explicit declared the minimum absolute mortality from breast cancer needed to warrant a MS program, however, the mortality rates of some LDCs are similar to those of DCs (Table 3). Female overall life expectancy is another parameter requiring consideration as low life expectancy results in fewer life years that can be saved via MS. For example, in Sudan the breast cancer mortality rate (15.2 per 100,000 people) is similar to that of the US (14.9) and Canada (13.9), however Sudanese female life expectancy is almost 20 years shorter. Thus even if Sudan has met the other qualifying prerequisites, the population as a whole would not benefit from MS.
Factors effecting sensitivity and specificity of MS
Mammographic sensitivity was 80 % among women with predominantly fatty breasts, and just 30 % in women with extremely dense breasts (Mandelson et al. 2000). With age increases, breast density decreases and MS efficacy increases. MS reduces mortality by about 20–35 % in women aged 50–69 years, with less reduction in women aged 40–49 years, (Elmore et al. 2005) and increased false positive in younger women with high density (Salas et al. 2011). Hence, target population with low breast density may benefit more from MS. Breast density may exist across racial groups, greater in Asian women and least in African women, rely on BMI, age at screening, diet and alcohol intake, (del Carmen et al. 2007; Voevodina et al. 2013) differences in age-specific breast density and mammographic sensitivity need to be considered when deciding whether to initiate MS in any specific LDC.
Socioeconomic and educational level
Socioeconomic and educational levels and cancer awareness all affect the feasibility and utility of MS programs. Women in the US and Canada with high incomes and education levels were more likely to receive MS, (Katz and Hofer 1994) and women of low socioeconomic status show a low re-attendance screening rate according to the experience of Ontario Breast Screening Program (Tatla et al. 2003). Population in many LDCs is of insufficient socioeconomic status and low cancer awareness, which will make a screening program of insufficient utility, (Goss et al. 2014) such as the coverage rate of one regional MS program was shown to be is only about 30 % in Russia (Zakharova et al. 2011). Hence, health care systems must have medical record systems that follow patients over time, and education center may help to increase re-screening rate. For example, through telephone reminder and guidance, percentage of women had mammograms increased from 3.9 to 46.4 % in Turkey (Baysal and Gozum 2011).
Due to the points discussed above, simply applying the screening population taken from the existing guidelines from DCs will not be effective in LDCs. In LDCs, the average age of women with breast cancer is 10–20 years younger than women in the Western countries (Moore et al. 2003). Therefore, we suggest that women with the highest breast cancer incidence rate in socioeconomically well-developed areas of LDCs can attempt to be considered for the target population of a MS program. The potential size of the target population can be estimated with age distribution data.
Evaluation of mammography resources and requirements for a MS program
A minimum density of mammography machines is necessary in order to facilitate an efficient and accessible nationwide program. Most LDCs lack adequate health care infrastructure for their entire population, (Melnikow et al. 2013) the ratio of mammography equipments to physicians who perform CBE is close to 20 % in the US, but less than 0.25 % in India, (Sarvazyan et al. 2008) and in 2010 Sudan had only nine mammogram machines (WHO 2010. Canada has a mammography machine density of 72 per 1,000,000, while Mexico has a density of 37 per 1,000,000 (Chavarri-Guerra et al. 2012). The distribution of equipment is irregular due to economical heterogeneity in LDCs. In Brazil, the distribution ranges from two mammography machines in the northern state of Roraima (population of 450,579 in 2010) to 335 machines in the southeastern state of São Paulo (population 41,262,199 in 2010) (Lee et al. 2012). The distance the target population must travel and how long it takes to access MS may impact the adherence rate of a program. Whether mobile mammography, which may help women overcome the socioeconomic barriers to screening in US, such as lack of transportation, financial limitations or lack of medical insurance, (Carkaci et al. 2013) can be applied in LDCs with low population density need further investigation.
The quality and maintenance of mammography equipment is also of importance, as an example 20 % of mammography facilities in some areas of Brazil are out of use (Lee et al. 2012). Meanwhile, competency and continuous medical education of personnel working in a MS program also needs attention. A scarcity of technicians and radiologists specialized in breast imaging in Mexico and in the majority of Latin American countries, (Rodriguez-Cuevas et al. 2009) may lead to a sub-optimized outcomes of MS implementation in these resource limited LDCs.
Optimizing methods of MS program
How to optimize and form an “effective and affordable” method for the implementation of MS in LDCs is a big challenge.
Screening methods: age range, interval, direction, technique and review methods
Screening strategies differ in the existing and past MS programs (shown in Table 1). No evidence showed different methods led to different screening outcome in LDCs. Data from DCs demonstrate that screening benefit is reduced in younger women, even with shorter intervals (Pace and Keating 2014). Hence, although some guidelines recommend initiating annually mammography at age 40, (Smith et al. 2003; Henderson et al. 2003; American College of Obstetricians-Gynecologists 2011; Drukteinis et al. 2013) the US Preventive Services Task Force (USPSTF) recommends against routine screening mammography in women aged 40–49 years, and biennial screening mammography for women between the ages of 50 and 74 years (US Preventive Services Task Force 2009). For women over 50 years in UK, annual screening is predicted to have a relatively small effect on breast cancer mortality, with a relative risk of death at 0.95 compared with a 3-year screening interval (United Kingdom Co-ordinating Committee on Cancer Research 2002). Single-view mammography was used in the Swedish Two-county and Stockholm trials, while two-view mammography was used in the Malmo, Goteborg, Health Insurance Plan and Canadian trials, and in the first screen in Edinburgh, (The International Agency for Research on Cancer (IARC) 2002 two views were medically more effective and reduced recall rates, (Wald et al. 1995) while no significant difference found in the reduction in breast cancer mortality between one view or two views (Kerlikowske et al. 1995). No randomized controlled trials have compared digital or film mammography specifically, and although digital mammography is generally considered to be more effective it is more expensive (Melnikow et al. 2013). Double reading by two physicians increased the rate of cancer detection, (Dinnes et al. 2001) although using computer-aided detection with final diagnosis determined by one physician might be more cost-effective method (Sato et al. 2012).
Combining CBE/BSE (breast self exam) or other imaging technology
The evidence supporting the value of combining CBE and BSE as methods to reduce breast cancer mortality is limited and mostly inferential (Drukteinis et al. 2013). Canadian guidelines recommend against BSE and CBE; (Tonelli et al. 2011) USPSTF recommends against BSE and cites insufficient evidence to recommend CBE; (US Preventive Services Task Force 2009) and ACOG recommends annual CBE to women >40 years and BSE only for high risk patients (American College of Obstetricians-Gynecologists 2011). Ultrasound is an established adjunct to mammography in imaging evaluation, can be an option for additional screening in women at high risk, similarly in candidates for magnetic resonance imaging (Smith et al. 2003; Henderson et al. 2003). With routinely MS, CBE/BSE may not improve outcome, however, in LDCs, training of BSE by increasing cancer awareness, may also improve early detection. Limited evidence showed that women who had CBE were more likely to undergo MS in Malaysia, (Dahlui et al. 2012) and ultrasound combined with mammography may result in effective protection for Chinese women based on the younger age at tumor onset (Huang et al. 2001).
The best method is still inconclusive and data from studies performed in DCs should be considered prudentially in the setting of LDCs. It is necessary to create an “individualized” MS method for LDCs depending on different populations and medical resources, learning from the experiences in DCs and making appropriate improvements and modifications.
Short term outcomes of MS implementation appear promising in LDCs, in Brazil patients with clinical stage 0–1 disease increased from 50 to 70.8 %; (Silva et al. 2013). In Russia, the average cancer detection rate was 2.5 per 1000 women screened, with a significant increase in breast cancer incidence and a significant trend of decreased breast-cancer-related mortality; (Zakharova et al. 2011). In Hungary, percentage of women undergoing mammography increased from 27.4 to 61.0 % in 2002–2003, and 56.3 % in 2004–2005 after the introduction of the nationwide program (Boncz et al. 2008).
Long term outcomes are still unclear in LDCs, such as the precise mortality reduction rate, the overdiagnosis rate and false positive rate. Based on the current evidence from DC, they are still controversial (Jorgensen 2013). Some studies show a “significant” mortality reduction benefit of as much as 28–65 %, (Berry et al. 2005) while others show a “minimum” benefit of as little as 15 % (Gotzsche and Jorgensen 2013). Improvement in systemic treatments also contributed to mortality reduction, as 30 % reduction in breast cancer mortality was observed after screening and adjuvant therapy, 10 % of this reduction is due to screening and 20 % is due to treatment (Berry 2013). Overdiagnosis refers to MS detected breast cancers that might never have progressed to become symptomatic during a woman’s lifetime (The International Agency for Research on Cancer (IARC) 2002). SEER (Surveillance, Epidemiology, and End Results) incidence and mortality data showed increased cancer diagnosis with no obvious change in cancer mortality, suggesting the existence of overdiagnosis (Welch and Black 2010). Based on varying assumptions and statistical methods, one study extracted incidence data from two randomized controlled trials and found a “minimum rate” to be around 1 %; (Duffy et al. 2005) while a review based on published trends on incidence in five DCs found a “substantial rate” of 52 % (Jorgensen and Gotzsche 2009). Plausible estimates need appropriate adjustments for lead time bias and the pre-existing trend of increasing incidence in the population, so an overdiagnosis rate range from 1 to 10 % is generally accepted (Puliti et al. 2012). False positive findings are another inevitable challenge, may result in subsequent unnecessary surgical intervention, as well as greater short-term and long-term negative psychosocial consequences (Brodersen and Siersma 2013). Estimated false positive rate was 17 % for women undergoing 10 biennial screening tests in Europe, (Paci 2012) and about 61 % for 40- or 50-year-old women undergoing 10 years of annual mammography in US (Pace and Keating 2014).
There is no single gold standard for reaching an unbiased and reliable estimate of these long term outcomes, largely depending on the characteristic of target population and screening methods. Hence, we recommend small-scale MS trial should be conducted and followed up before the implementation of a nationwide program in LDCs.
All the parameters discussed above, including target population, screening resources, detail screening methods and evaluated outcome should be integrated into a CEA, which is the final key step to enable policy makers to put forward a medical practice (Weinstein and Stason 1977). Generally incremental cost effectiveness ratio (ICER) is accepted to estimate the expected cost of a MS to units such as per life year saved, per quality adjusted life year (QALY) saved, per disability adjusted life year (DALY) averted and so on (Laxminarayan et al. 2006). Biennial digital mammography beginning at age 50 resulted in an incremental cost per life year of US$17,050 in the US, (Melnikow et al. 2013) and once every 3 years beginning at age 50 in the UK was associated with £20,800 (US$34,784) per QALY gained (Pharoah et al. 2013). These results cannot be directly applicable to LDCs, each CEA should be assessed on a country-by-country basis. There is no data shows exactly what amount of “incremental cost” is acceptable for individual LDCs, definitely not as much as that identical to the £20,000–30,000 per QALY established in the UK (National Institute for Health and Care Excellence 2014). Complex models require many assumptions, usually estimated by extrapolating data from clinical results, are highly susceptible to both error and introduction of bias, (Detsky and Laupacis 2007) hampering CEA conducted in LDCs. Limited data demonstrated that biennial MS for women aged 40–60 years in India resulted in a cost of around US$3468 per life year gained, (Okonkwo et al. 2008) and around US$6516 (R$13573.07) in Brazil, (Peregrino et al. 2012) policy makers struggle with determining the net benefit and dare not to quickly implement such a program.
We suggest crosswise and longitudinal comparisons can be used to roughly estimate the practicality of MS in LDCs. In a crosswise comparison, for example, 1 year of adjuvant trastuzumab was determined to be a cost-effective treatment option in early-stage breast cancer, with the ICER per QALY was around US$8000 in China, (Chen et al. 2009) and US$18,970 in the US (Liberato et al. 2007). Based on ICER results of trastuzumab, by comparing ICER of MS in the US with the result estimated for MS in China, we can roughly estimate whether such a program is worthy to carry out in China. In a longitudinal comparison, we can use of the cost-effectiveness (CE)/GDP per capita ratio, (Yoo et al. 2013) as well as CE/yearly health expenditures per capita ratio, (van Ineveld et al. 1993) to balance the differences among countries. If the CE/GDP per capita ratio is greater than 1, then MS can be deemed inefficient, as the cost per life year saved exceeds the per capita GDP. Of note, individual cost-effectiveness ratios are estimated for a single program, not for a group of programs vying for a fixed budget (Detsky and Laupacis 2007). To maximize health outcomes from a limited budget, policy makers still face the challenge of prudentially and equitably allocating resources across a defined number of competing needs (Detsky and Naglie 1990).
According to this “five steps” model proposed here, we have tested MS in Shanghai cautiously, trying to meet all the criteria required for implementation. Shanghai is a prosperous urban city of China, with relatively better medical resources. Cancer registry was set up since 1970’, and “Shanghai Cancer Report” is published by Shanghai Center of Disease Control yearly, with detail information of age specific cancer incidence, mortality and prevalence. We selected women with highest incidence rate (age of 45–69 years old) as target population. Two-view film mammography with annual screening was used in a localized area in Shanghai. Sensitivity of MS was tested in different age group, 65.4 % in age 45–59 years and 66.8 % in age 60–69 years (Mo et al. 2013). With adequate follow-up, long term outcome can be analyzed and CEA will be conducted in the near future. Then screening methods may necessarily be modified, combing with breast exam and/or ultrasound. Only when net benefit has been observed, we may implement such a program to all over Shanghai.
LDCs have experienced a marked increase in breast cancer burden, (Ferlay et al. 2013) with poor cancer awareness of the public, delayed diagnosis, and non-optimal and untimely treatment. Efforts are needed to improve patient outcomes (Goss et al. 2014). Most LDCs prioritize early detection of breast cancer, and some may be eager to achieve this through MS programs. The aim of this review is to illustrate the status of existing and past MS program attempts in LDCs and outline the challenge and limitations of MS in these countries.
There are some limitations to this review. Firstly, the definition of LDCs varied- our definition is similar to the World Bank’s term “developing economies,” which includes low- and middle-income economies, with gross national income (GNI) per capita of less than US$12,616 (The World Bank 2014a). Discrepancies exist, for example, although Russia is categorized as a high income country, it is still regarded as a developing country by the World Bank, and therefore was included in our analysis. Secondly, our review was limited to literature published in English, therefore we may have omitted studies published in local journals or listed in non-English databases. Thirdly, our review does not cover all parameters related to launching a MS program, but instead we have selected factors which we believe are most important for defining a target population, assessing whether a country is well-equipped, and designing and evaluating the practicality of such a program.
Increasing efforts for breast cancer screening have been made in LDCs: national recommendations and/or guidelines have been laid out, MS programs had been incorporated in some countries and relevant studies have been conducted in others. Based on our review, there may be a role in LDCs to employ western style MS for targeted minority groups, such as high socioeconomic level and high risk populations. Meanwhile, for LDCs, it is also important to ensure patient follow-up to maintain high adherence rates, to ensure the accuracy of screening mammography, to shorten the waiting time to definitive diagnostic procedure after suspicious results, and to deliver state-of-the art treatment after early detection by screening. MS programs are currently too resource-demanding for most LDCs, due to the lack of breast cancer awareness among the population, the inadequate identification of appropriate target populations, the low likelihood of up-take and compliance, the scarcity of mammography resources, unaffordable screening costs and overall sub-optimal outcomes in survival benefit.
JJL and ZMS planned and wrote the Review. JJL did the literature search and participated in the concept design. JJL prepared the figures and tables. ZMS participated in the concept development, writing, editing. Both authors read and approved the final manuscript.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors.
The authors declare that they have no competing interests.
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