Adams LA, Lymp JF, St Sauver J, Sanderson SO, Lindor KD, Feldstein A, Angulo P: The natural history of nonalcoholic fatty liver disease: a population-based cohort study. Gastroenterology 2005, 129(1):113-121. 10.1053/j.gastro.2005.04.014
Article
Google Scholar
Ando N, Shimizu M, Okuno M, Matsushima-Nishiwaki R, Tsurumi H, Tanaka T, Moriwaki H: Expression of retinoid X receptor alpha is decreased in 3′-methyl-4-dimethylaminoazobenzene-induced hepatocellular carcinoma in rats. Oncol Rep 2007, 18(4):879-884.
Google Scholar
Ascha MS, Hanouneh IA, Lopez R, Tamimi TA, Feldstein AF, Zein NN: The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis. Hepatology 2010, 51(6):1972-1978. doi:10.1002/hep.23527 10.1002/hep.23527
Article
Google Scholar
Bettuzzi S, Brausi M, Rizzi F, Castagnetti G, Peracchia G, Corti A: Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study. Cancer Res 2006, 66(2):1234-1240. doi:10.1158/0008-5472.CAN-05-1145 10.1158/0008-5472.CAN-05-1145
Article
Google Scholar
Chiang DJ, Pritchard MT, Nagy LE: Obesity, diabetes mellitus, and liver fibrosis. Am J Physiol Gastrointest Liver Physiol 2011, 300(5):G697-G702. doi:10.1152/ajpgi.00426.2010 10.1152/ajpgi.00426.2010
Article
Google Scholar
Cusi K: Role of obesity and lipotoxicity in the development of nonalcoholic steatohepatitis: pathophysiology and clinical implications. Gastroenterology 2012, 142(4):711-725. e716. doi:10.1053/j.gastro.2012.02.003 10.1053/j.gastro.2012.02.003
Article
Google Scholar
Day CP, James OF: Steatohepatitis: a tale of two “hits”? Gastroenterology 1998, 114(4):842-845. 10.1016/S0016-5085(98)70599-2
Article
Google Scholar
Grove KA, Lambert JD: Laboratory, epidemiological, and human intervention studies show that tea (Camellia sinensis) may be useful in the prevention of obesity. J Nutr 2010, 140(3):446-453. doi:10.3945/jn.109.115972 10.3945/jn.109.115972
Article
Google Scholar
Hebbard L, George J: Animal models of nonalcoholic fatty liver disease. Nat Rev Gastroenterol Hepatol 2011, 8(1):35-44. doi:10.1038/nrgastro.2010.191 10.1038/nrgastro.2010.191
Article
Google Scholar
Iwasa J, Shimizu M, Shiraki M, Shirakami Y, Sakai H, Terakura Y, Takai K, Tsurumi H, Tanaka T, Moriwaki H: Dietary supplementation with branched-chain amino acids suppresses diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-db/db mice. Cancer Sci 2010, 101(2):460-467. doi:10.1111/j.1349-7006.2009.01402.x 10.1111/j.1349-7006.2009.01402.x
Article
Google Scholar
Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, Cummings OW, Ferrell LD, Liu YC, Torbenson MS, Unalp-Arida A, Yeh M, McCullough AJ, Sanyal AJ: Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005, 41(6):1313-1321. doi:10.1002/hep.20701 10.1002/hep.20701
Article
Google Scholar
Kochi T, Shimizu M, Terakura D, Baba A, Ohno T, Kubota M, Shirakami Y, Tsurumi H, Tanaka T, Moriwaki H: Non-alcoholic steatohepatitis and preneoplastic lesions develop in the liver of obese and hypertensive rats: suppressing effects of EGCG on the development of liver lesions. Cancer Lett 2013. doi:10.1016/j.canlet.2013.08.031
Google Scholar
Kuzu N, Bahcecioglu IH, Dagli AF, Ozercan IH, Ustundag B, Sahin K: Epigallocatechin gallate attenuates experimental non-alcoholic steatohepatitis induced by high fat diet. J Gastroenterol Hepatol 2008, 23(8 Pt 2):e465-e470. doi:10.1111/j.1440-1746.2007.05052.x
Article
Google Scholar
Masterjohn C, Bruno RS: Therapeutic potential of green tea in nonalcoholic fatty liver disease. Nutr Rev 2012, 70(1):41-56. doi:10.1111/j.1753-4887.2011.00440.x 10.1111/j.1753-4887.2011.00440.x
Article
Google Scholar
Park EJ, Lee JH, Yu GY, He G, Ali SR, Holzer RG, Osterreicher CH, Takahashi H, Karin M: Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell 2010, 140(2):197-208. doi:10.1016/j.cell.2009.12.052 10.1016/j.cell.2009.12.052
Article
Google Scholar
Park HJ, DiNatale DA, Chung MY, Park YK, Lee JY, Koo SI, O’Connor M, Manautou JE, Bruno RS: Green tea extract attenuates hepatic steatosis by decreasing adipose lipogenesis and enhancing hepatic antioxidant defenses in ob/ob mice. J Nutr Biochem 2011, 22(4):393-400. doi:10.1016/j.jnutbio.2010.03.009 10.1016/j.jnutbio.2010.03.009
Article
Google Scholar
Powell EE, Jonsson JR, Clouston AD: Steatosis: co-factor in other liver diseases. Hepatology 2005, 42(1):5-13. doi:10.1002/hep.20750 10.1002/hep.20750
Article
Google Scholar
Sanyal AJ, Campbell-Sargent C, Mirshahi F, Rizzo WB, Contos MJ, Sterling RK, Luketic VA, Shiffman ML, Clore JN: Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology 2001, 120(5):1183-1192. doi:10.1053/gast.2001.23256 10.1053/gast.2001.23256
Article
Google Scholar
Sanyal AJ, Chalasani N, Kowdley KV, McCullough A, Diehl AM, Bass NM, Neuschwander-Tetri BA, Lavine JE, Tonascia J, Unalp A, Van Natta M, Clark J, Brunt EM, Kleiner DE, Hoofnagle JH, Robuck PR: Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. N Engl J Med 2010, 362(18):1675-1685. doi:10.1056/NEJMoa0907929 10.1056/NEJMoa0907929
Article
Google Scholar
Schattenberg JM, Galle PR: Animal models of non-alcoholic steatohepatitis: of mice and man. Dig Dis 2010, 28(1):247-254. doi:10.1159/000282097 10.1159/000282097
Article
Google Scholar
Shimizu M, Fukutomi Y, Ninomiya M, Nagura K, Kato T, Araki H, Suganuma M, Fujiki H, Moriwaki H: Green tea extracts for the prevention of metachronous colorectal adenomas: a pilot study. Cancer Epidemiol Biomarkers Prev 2008, 17(11):3020-3025. doi:10.1158/1055-9965.EPI-08-0528 10.1158/1055-9965.EPI-08-0528
Article
Google Scholar
Shimizu M, Shirakami Y, Sakai H, Adachi S, Hata K, Hirose Y, Tsurumi H, Tanaka T, Moriwaki H: (-)-Epigallocatechin gallate suppresses azoxymethane-induced colonic premalignant lesions in male C57BL/KsJ-db/db mice. Cancer Prev Res (Phila) 2008, 1(4):298-304. doi:10.1158/1940-6207.CAPR-08-0045 10.1158/1940-6207.CAPR-08-0045
Article
Google Scholar
Shimizu M, Sakai H, Shirakami Y, Iwasa J, Yasuda Y, Kubota M, Takai K, Tsurumi H, Tanaka T, Moriwaki H: Acyclic retinoid inhibits diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BLKS/J-+(db)/+Lepr(db) mice. Cancer Prev Res (Phila) 2011, 4(1):128-136. doi:10.1158/1940-6207.CAPR-10-0163 10.1158/1940-6207.CAPR-10-0163
Article
Google Scholar
Shimizu M, Sakai H, Shirakami Y, Yasuda Y, Kubota M, Terakura D, Baba A, Ohno T, Hara Y, Tanaka T, Moriwaki H: Preventive effects of (-)-epigallocatechin gallate on diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-db/db mice. Cancer Prev Res (Phila) 2011, 4(3):396-403. doi:10.1158/1940-6207.CAPR-10-0331 10.1158/1940-6207.CAPR-10-0331
Article
Google Scholar
Shimizu M, Yasuda Y, Sakai H, Kubota M, Terakura D, Baba A, Ohno T, Kochi T, Tsurumi H, Tanaka T, Moriwaki H: Pitavastatin suppresses diethylnitrosamine-induced liver preneoplasms in male C57BL/KsJ-db/db obese mice. BMC Cancer 2011, 11(1):281. doi:10.1186/1471-2407-11-281 10.1186/1471-2407-11-281
Article
Google Scholar
Shimizu M, Kubota M, Tanaka T, Moriwaki H: Nutraceutical approach for preventing obesity-related colorectal and liver carcinogenesis. Int J Mol Sci 2012, 13(1):579-595. doi:10.3390/ijms13010579
Article
Google Scholar
Shimizu M, Tanaka T, Moriwaki H: Obesity and hepatocellular carcinoma: targeting obesity-related inflammation for chemoprevention of liver carcinogenesis. Semin Immunopathol 2013, 35(2):191-202. doi:10.1007/s00281-012-0336-6 10.1007/s00281-012-0336-6
Article
Google Scholar
Shirakami Y, Shimizu M, Tsurumi H, Hara Y, Tanaka T, Moriwaki H: EGCG and Polyphenon E attenuate inflammation-related mouse colon carcinogenesis induced by AOM plus DDS. Mol Med Rep 2008, 1(3):355-361.
Google Scholar
Shirakami Y, Shimizu M, Adachi S, Sakai H, Nakagawa T, Yasuda Y, Tsurumi H, Hara Y, Moriwaki H: (-)-Epigallocatechin gallate suppresses the growth of human hepatocellular carcinoma cells by inhibiting activation of the vascular endothelial growth factor-vascular endothelial growth factor receptor axis. Cancer Sci 2009, 100(10):1957-1962. doi:10.1111/j.1349-7006.2009.01241.x 10.1111/j.1349-7006.2009.01241.x
Article
Google Scholar
Siegel AB, Zhu AX: Metabolic syndrome and hepatocellular carcinoma: two growing epidemics with a potential link. Cancer 2009, 115(24):5651-5661. doi:10.1002/cncr.24687 10.1002/cncr.24687
Article
Google Scholar
Suzuki Y, Imai K, Takai K, Hanai T, Hayashi H, Naiki T, Nishigaki Y, Tomita E, Shimizu M, Moriwaki H: Hepatocellular carcinoma patients with increased oxidative stress levels are prone to recurrence after curative treatment: a prospective case series study using the d-ROM test. J Cancer Res Clin Oncol 2013, 139(5):845-852. doi:10.1007/s00432-013-1389-1 10.1007/s00432-013-1389-1
Article
Google Scholar
Terakura D, Shimizu M, Iwasa J, Baba A, Kochi T, Ohno T, Kubota M, Shirakami Y, Shiraki M, Takai K, Tsurumi H, Tanaka T, Moriwaki H: Preventive effects of branched-chain amino acid supplementation on the spontaneous development of hepatic preneoplastic lesions in C57BL/KsJ-db/db obese mice. Carcinogenesis 2012, 33(12):2499-2506. doi:10.1093/carcin/bgs303 10.1093/carcin/bgs303
Article
Google Scholar
Thielecke F, Boschmann M: The potential role of green tea catechins in the prevention of the metabolic syndrome - a review. Phytochemistry 2009, 70(1):11-24. doi:10.1016/j.phytochem.2008.11.011 10.1016/j.phytochem.2008.11.011
Article
Google Scholar
Tsuda H, Fukushima S, Wanibuchi H, Morimura K, Nakae D, Imaida K, Tatematsu M, Hirose M, Wakabayashi K, Moore MA: Value of GST-P positive preneoplastic hepatic foci in dose–response studies of hepatocarcinogenesis: evidence for practical thresholds with both genotoxic and nongenotoxic carcinogens. A review of recent work. Toxicol Pathol 2003, 31(1):80-86.
Google Scholar
Ueno T, Torimura T, Nakamura T, Sivakumar R, Nakayama H, Otabe S, Yuan X, Yamada K, Hashimoto O, Inoue K, Koga H, Sata M: Epigallocatechin-3-gallate improves nonalcoholic steatohepatitis model mice expressing nuclear sterol regulatory element binding protein-1c in adipose tissue. Int J Mol Med 2009, 24(1):17-22.
Article
Google Scholar
Wang ZY, Agarwal R, Bickers DR, Mukhtar H: Protection against ultraviolet B radiation-induced photocarcinogenesis in hairless mice by green tea polyphenols. Carcinogenesis 1991, 12(8):1527-1530. 10.1093/carcin/12.8.1527
Article
Google Scholar
Wang Y, Ausman LM, Greenberg AS, Russell RM, Wang XD: Nonalcoholic steatohepatitis induced by a high-fat diet promotes diethylnitrosamine-initiated early hepatocarcinogenesis in rats. Int J Cancer 2009, 124(3):540-546. doi:10.1002/ijc.23995 10.1002/ijc.23995
Article
Google Scholar
Wang Y, Ausman LM, Greenberg AS, Russell RM, Wang XD: Dietary lycopene and tomato extract supplementations inhibit nonalcoholic steatohepatitis-promoted hepatocarcinogenesis in rats. Int J Cancer 2010, 126(8):1788-1796. doi:10.1002/ijc.24689
Google Scholar
Yang S, Lin HZ, Hwang J, Chacko VP, Diehl AM: Hepatic hyperplasia in noncirrhotic fatty livers: is obesity-related hepatic steatosis a premalignant condition? Cancer Res 2001, 61(13):5016-5023.
Google Scholar
Yang CS, Wang X, Lu G, Picinich SC: Cancer prevention by tea: animal studies, molecular mechanisms and human relevance. Nat Rev Cancer 2009, 9(6):429-439. doi:10.1038/nrc2641 10.1038/nrc2641
Article
Google Scholar
Zein CO, Yerian LM, Gogate P, Lopez R, Kirwan JP, Feldstein AE, McCullough AJ: Pentoxifylline improves nonalcoholic steatohepatitis: a randomized placebo-controlled trial. Hepatology 2011, 54(5):1610-1619. doi:10.1002/hep.24544 10.1002/hep.24544
Article
Google Scholar