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Figure 1

From: (—)-Epigallocatechin-3-gallate suppresses hepatic preneoplastic lesions developed in a novel rat model of non-alcoholic steatohepatitis

Figure 1

Hepatic histopathology, intrahepatic levels of triglycerides, and serum levels of ALT. (a) and (b) H&E staining of liver sections from the experimental rats. (a) Representative photomicrographs of liver sections of rats treated DEN/HFD with or without EGCG. Bars, 100 μm. (b) An enlarged photo of the liver section from a rat treated DEN/HFD without EGCG (an enclosed area with square in Figure 1a). Note ballooned hepatocytes (indicated by the white arrow), Mallory-Denk bodies (indicated by the black arrow), and focus of inflammatory cells (circled by dotted line). Bars, 50 μm. (c) The NAS was determined from histopathological analysis. (d) Hepatic lipids were extracted from frozen liver samples of rats in the 3 groups, and the triglyceride (TG) levels were measured. (e) Blood samples were collected at sacrifice and the serum levels of alanine aminotransferase (ALT) were determined. The values are expressed as mean ± SD. *P < 0.05. Ctrl, control group.

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