Adzhubei IA, Schmidt S, Peshkin L, Ramensky VE, Gerasimova A, Bork P, Kondrashov AS, Sunyaev SR: A method and server for predicting damaging missense mutations. Nat Methods 2010,7(4):248-249. 10.1038/nmeth0410-248
Article
Google Scholar
Boyle JP, Thompson TJ, Gregg EW, Barker LE, Williamson DF: Projection of the year 2050 burden of diabetes in the US adult population: dynamic modeling of incidence, mortality, and prediabetes prevalence. Population health metrics 2010, 8: 29. 10.1186/1478-7954-8-29
Article
Google Scholar
Combs TP, Berg AH, Obici S, Scherer PE, Rossetti L: Endogenous glucose production is inhibited by the adipose-derived protein Acrp30. J Clin Invest 2001,108(12):1875-1881.
Article
Google Scholar
Dolan LM, Bean J, D’Alessio D, Cohen RM, Morrison JA, Goodman E, Daniels SR: Frequency of abnormal carbohydrate metabolism and diabetes in a population-based screening of adolescents. J Pediatr 2005,146(6):751-758. 10.1016/j.jpeds.2005.01.045
Article
Google Scholar
Ebinuma H, Miyazaki O, Yago H, Hara K, Yamauchi T, Kadowaki T: A novel ELISA system for selective measurement of human adiponectin multimers by using proteases. Clin Chim Acta 2006,372(1–2):47-53.
Article
Google Scholar
Eckel RH, Kahn SE, Ferrannini E, Goldfine AB, Nathan DM, Schwartz MW, Smith RJ, Smith SR: Obesity and type 2 diabetes: what can be unified and what needs to be individualized? J Clin Endocrinol Metab 2011,96(6):1654-1663. 10.1210/jc.2011-0585
Article
Google Scholar
Filippi E, Sentinelli F, Trischitta V, Romeo S, Arca M, Leonetti F, Di Mario U, Baroni MG: Association of the human adiponectin gene and insulin resistance. Eur J Hum Genet 2004,12(3):199-205. 10.1038/sj.ejhg.5201120
Article
Google Scholar
Flanagan SE, Patch AM, Ellard S: Using SIFT and PolyPhen to predict loss-of-function and gain-of-function mutations. Genet Test Mol Biomarkers 2010,14(4):533-537. 10.1089/gtmb.2010.0036
Article
Google Scholar
Frystyk J, Tarnow L, Hansen TK, Parving HH, Flyvbjerg A: Increased serum adiponectin levels in type 1 diabetic patients with microvascular complications. Diabetologia 2005,48(9):1911-1918. 10.1007/s00125-005-1850-z
Article
Google Scholar
Gupta AC, Misra R, Sakhuja P, Singh Y, Basir SF, Sarin SK: Association of adiponectin gene functional polymorphisms (−11377C/G and +45 T/G) with nonalcoholic fatty liver disease. Gene 2012,496(1):63-67. 10.1016/j.gene.2011.12.023
Article
Google Scholar
Heid IM, Henneman P, Hicks A, Coassin S, Winkler T, Aulchenko YS, Fuchsberger C, Song K, Hivert MF, Waterworth DM, Timpson NJ, Richards JB, Perry JR, Tanaka T, Amin N, Kollerits B, Pichler I, Oostra BA, Thorand B, Frants RR, Illig T, Dupuis J, Glaser B, Spector T, Guralnik J, Egan JM, Florez JC, Evans DM, Soranzo N, Bandinelli S, et al.: Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: results of genome-wide association analyses including 4659 European individuals. Atherosclerosis 2010,208(2):412-420. 10.1016/j.atherosclerosis.2009.11.035
Article
Google Scholar
Hivert MF, Manning AK, McAteer JB, Florez JC, Dupuis J, Fox CS, O’Donnell CJ, Cupples LA, Meigs JB: Common variants in the adiponectin gene (ADIPOQ) associated with plasma adiponectin levels, type 2 diabetes, and diabetes-related quantitative traits: the Framingham Offspring Study. Diabetes 2008,57(12):3353-3359. 10.2337/db08-0700
Article
Google Scholar
Hotta K, Funahashi T, Bodkin NL, Ortmeyer HK, Arita Y, Hansen BC, Matsuzawa Y: Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys. Diabetes 2001,50(5):1126-1133. 10.2337/diabetes.50.5.1126
Article
Google Scholar
Jungtrakoon P, Plengvidhya N, Tangjittipokin W, Chimnaronk S, Salaemae W, Chongjaroen N, Chanprasert K, Sujjitjoon J, Srisawat C, Yenchitsomanus PT: Novel adiponectin variants identified in type 2 diabetic patients reveal multimerization and secretion defects. PLoS One 2011,6(10):e26792. 10.1371/journal.pone.0026792
Article
Google Scholar
Kondo H, Shimomura I, Matsukawa Y, Kumada M, Takahashi M, Matsuda M, Ouchi N, Kihara S, Kawamoto T, Sumitsuji S, Funahashi T, Matsuzawa Y: Association of adiponectin mutation with type 2 diabetes: a candidate gene for the insulin resistance syndrome. Diabetes 2002,51(7):2325-2328. 10.2337/diabetes.51.7.2325
Article
Google Scholar
Kretowski A, Gugala K, Okruszko A, Wawrusiewicz-Kurylonek N, Gorska M: Single Nucleotide Polymorphisms in exon 3 of the adiponectin gene in subjects with type 2 diabetes mellitus. Rocz Akad Med Bialymst 2005, 50: 148-150.
Google Scholar
Kumar P, Henikoff S, Ng PC: Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. Nat Protoc 2009,4(7):1073-1081.
Article
Google Scholar
Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970,227(5259):680-685. 10.1038/227680a0
Article
Google Scholar
Laumen H, Saningong AD, Heid IM, Hess J, Herder C, Claussnitzer M, Baumert J, Lamina C, Rathmann W, Sedlmeier EM, Klopp N, Thorand B, Wichmann HE, Illig T, Hauner H: Functional characterization of promoter variants of the adiponectin gene complemented by epidemiological data. Diabetes 2009,58(4):984-991. 10.2337/db07-1646
Article
Google Scholar
Lindsay RS, Funahashi T, Hanson RL, Matsuzawa Y, Tanaka S, Tataranni PA, Knowler WC, Krakoff J: Adiponectin and development of type 2 diabetes in the Pima Indian population. Lancet 2002,360(9326):57-58. 10.1016/S0140-6736(02)09335-2
Article
Google Scholar
Mackevics V, Heid IM, Wagner SA, Cip P, Doppelmayr H, Lejnieks A, Gohlke H, Ladurner G, Illig T, Iglseder B, Kronenberg F, Paulweber B: The adiponectin gene is associated with adiponectin levels but not with characteristics of the insulin resistance syndrome in healthy Caucasians. Eur J Hum Genet 2006,14(3):349-356. 10.1038/sj.ejhg.5201552
Article
Google Scholar
Maeda N, Shimomura I, Kishida K, Nishizawa H, Matsuda M, Nagaretani H, Furuyama N, Kondo H, Takahashi M, Arita Y, Komuro R, Ouchi N, Kihara S, Tochino Y, Okutomi K, Horie M, Takeda S, Aoyama T, Funahashi T, Matsuzawa Y: Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat Med 2002,8(7):731-737. 10.1038/nm724
Article
Google Scholar
Martin LJ, Woo JG, Daniels SR, Goodman E, Dolan LM: The relationships of adiponectin with insulin and lipids Are strengthened with increasing adiposity. J Clin Endocrinol Metab 2005,90(7):4255-4259. 10.1210/jc.2005-0019
Article
Google Scholar
Morales A, Wasserfall C, Brusko T, Carter C, Schatz D, Silverstein J, Ellis T, Atkinson M: Adiponectin and leptin concentrations may aid in discriminating disease forms in children and adolescents with type 1 and type 2 diabetes. Diabetes Care 2004,27(8):2010-2014. 10.2337/diacare.27.8.2010
Article
Google Scholar
Mousavinasab F, Tahtinen T, Jokelainen J, Koskela P, Vanhala M, Oikarinen J, Keinanen-Kiukaanniemi S, Laakso M: Common polymorphisms (single-nucleotide polymorphisms SNP + 45 and SNP + 276) of the adiponectin gene regulate serum adiponectin concentrations and blood pressure in young Finnish men. Mol Genet Metab 2006,87(2):147-151. 10.1016/j.ymgme.2005.08.010
Article
Google Scholar
Ng PC, Henikoff S: SIFT: Predicting amino acid changes that affect protein function. Nucleic Acids Res 2003,31(13):3812-3814. 10.1093/nar/gkg509
Article
Google Scholar
Ogden CL, Carroll MD, Kit BK, Flegal KM: Prevalence of obesity and trends in body mass index among US children and adolescents, 1999–2010. JAMA 2012,307(5):483-490. 10.1001/jama.2012.40
Article
Google Scholar
Pajvani UB, Hawkins M, Combs TP, Rajala MW, Doebber T, Berger JP, Wagner JA, Wu M, Knopps A, Xiang AH, Utzschneider KM, Kahn SE, Olefsky JM, Buchanan TA, Scherer PE: Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity. J Biol Chem 2004,279(13):12152-12162.
Article
Google Scholar
Takahashi M, Arita Y, Yamagata K, Matsukawa Y, Okutomi K, Horie M, Shimomura I, Hotta K, Kuriyama H, Kihara S, Nakamura T, Yamashita S, Funahashi T, Matsuzawa Y: Genomic structure and mutations in adipose-specific gene, adiponectin. Int J Obes Relat Metab Disord 2000,24(7):861-868. 10.1038/sj.ijo.0801244
Article
Google Scholar
Tsao TS, Murrey HE, Hug C, Lee DH, Lodish HF: Oligomerization state-dependent activation of NF-kappa B signaling pathway by adipocyte complement-related protein of 30 kDa (Acrp30). J Biol Chem 2002,277(33):29359-29362. 10.1074/jbc.C200312200
Article
Google Scholar
Ujiie H, Oritani K, Kato H, Yokota T, Takahashi I, Maeda T, Masaie H, Ichii M, Kamada Y, Tamura S, Kihara S, Funahashi T, Tomiyama Y, Kanakura Y: Identification of amino-terminal region of adiponectin as a physiologically functional domain. J Cell Biochem 2006,98(1):194-207. 10.1002/jcb.20779
Article
Google Scholar
Vasseur F, Helbecque N, Dina C, Lobbens S, Delannoy V, Gaget S, Boutin P, Vaxillaire M, Lepretre F, Dupont S, Hara K, Clement K, Bihain B, Kadowaki T, Froguel P: Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians. Hum Mol Genet 2002,11(21):2607-2614. 10.1093/hmg/11.21.2607
Article
Google Scholar
Waki H, Yamauchi T, Kamon J, Ito Y, Uchida S, Kita S, Hara K, Hada Y, Vasseur F, Froguel P, Kimura S, Nagai R, Kadowaki T: Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin. J Biol Chem 2003,278(41):40352-40363. 10.1074/jbc.M300365200
Article
Google Scholar
Wheeler DA, Srinivasan M, Egholm M, Shen Y, Chen L, McGuire A, He W, Chen YJ, Makhijani V, Roth GT, Gomes X, Tartaro K, Niazi F, Turcotte CL, Irzyk GP, Lupski JR, Chinault C, Song XZ, Liu Y, Yuan Y, Nazareth L, Qin X, Muzny DM, Margulies M, Weinstock GM, Gibbs RA, Rothberg JM: The complete genome of an individual by massively parallel DNA sequencing. Nature 2008,452(7189):872-876. 10.1038/nature06884
Article
Google Scholar
Woo JG, Dolan LM, Deka R, Kaushal RD, Shen Y, Pal P, Daniels SR, Martin LJ: Interactions between noncontiguous haplotypes in the adiponectin gene ACDC are associated with plasma adiponectin. Diabetes 2006,55(2):523-529. 10.2337/diabetes.55.02.06.db05-0446
Article
Google Scholar
Writing Group for the Search for Diabetes in Youth Study Group, Dabelea D, Bell RA, D’Agostino RB, Jr., Imperatore G, Johansen JM, Linder B, Liu LL, Loots B, Marcovina S, Mayer-Davis EJ, Pettitt DJ, Waitzfelder B: Incidence of diabetes in youth in the United States. JAMA 2007,297(24):2716-2724.
Article
Google Scholar
Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S, Yamashita S, Noda M, Kita S, Ueki K, Eto K, Akanuma Y, Froguel P, Foufelle F, Ferre P, Carling D, Kimura S, Nagai R, Kahn BB, Kadowaki T: Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 2002,8(11):1288-1295. 10.1038/nm788
Article
Google Scholar
Zou M, Baitei EY, Alzahrani AS, Parhar RS, Al-Mohanna FA, Meyer BF, Shi Y: Mutation prediction by PolyPhen or functional assay, a detailed comparison of CYP27B1 missense mutations. Endocrine 2011,40(1):14-20. 10.1007/s12020-011-9489-7
Article
Google Scholar