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  3. The microseminoprotein gene encoding prostate secretory protein of 94 amino acids (PSP94) harbours a potential risk allele (rs10993994) for prostate cancer (PCa) in its promoter region. However, studies on rs1...

    Authors: Deepa R Mhatre, Smita D Mahale, Mohammed I Khatkhatay, Swati K Achrekar, Swapna S Desai, Dhanashree D Jagtap, Jayesh V Dhabalia, Hemant B Tongaonkar, Sucheta P Dandekar and Anand M Varadkar
    Citation: SpringerPlus 2015 4:380
    Content type: Research Published on:

  5. The hernia of Amyand is an inguinal hernia containing the appendix in the sac. It is a rare pathology often diagnosed only intra-operatively. We report a case even more rare of a giant left-sided inguinoscrota...

    Authors: Massimo Mongardini, Alessandro Maturo, Livia De Anna, Giada Livadoti, Valerio D’Orazi, Paolo Urciuoli and Filippo Custureri
    Citation: SpringerPlus 2015 4:378
    Content type: Case study Published on:

  6. We investigated the effect of Katsura-uri (Japanese pickling melon; Cucumis melo var. conomon) on energy metabolism during exercise in human and animal studies.

    Authors: Wataru Aoi, Kazuya Takeda, Azusa Sasaki, Yuki Hasegawa, Yasushi Nakamura, Eun Young Park, Kenji Sato, Masayo Iwasa, Airi Nakayama, Mizuki Minamikawa, Yukiko Kobayashi, Koji Shirota and Noboru Suetome
    Citation: SpringerPlus 2015 4:377
    Content type: Research Published on:

    The Erratum to this article has been published in SpringerPlus 2015 4:530

  7. Combination chemotherapy with mitomycin C and methotrexate (MM) was reported to be effective for 24% of patients with metastatic breast cancer (MBC) who had been treated with anthracycline and taxane. Antimeta...

    Authors: Takayo Fukuda, Masahiko Tanabe, Kokoro Kobayashi, Ippei Fukada, Shunji Takahashi, Takuji Iwase and Yoshinori Ito
    Citation: SpringerPlus 2015 4:376
    Content type: Research Published on:

  8. SS18–SSX (formerly called SYT–SSX) fusion gene has been established clinically as a molecular diagnostic test for synovial sarcoma, but the prognostic value of the fusion gene variant for survival is controve...

    Authors: Tadahiko Kubo, Shoji Shimose, Jun Fujimori, Taisuke Furuta and Mitsuo Ochi
    Citation: SpringerPlus 2015 4:375
    Content type: Review Published on:

  9. Here we devise an approach to model error and its propagation. Without approximations, we define the uncertainty of a measurement as its maximum possible error (maper). Thus, we propose and solve analytically two...

    Authors: Eduardo Del Rio and Luiz Felipe Ferreira
    Citation: SpringerPlus 2015 4:374
    Content type: Research Published on:

  11. Environmental hazards were shown to have an impact on cell proliferation (CP). We investigated CP of lymphocytes in umbilical cord blood in relation to prenatal environmental exposures in a sample of 346 Arab-...

    Authors: Lena Novack, Esther Manor, Elena Gurevich, Maayan Yitshak-Sade, Daniella Landau, Batia Sarov, Reli Hershkovitz, Doron Dukler, Tali Vodonos and Isabella Karakis
    Citation: SpringerPlus 2015 4:372
    Content type: Research Published on:

  12. Intra-abdominal abscesses are the most common complication after perforated appendicitis and remain a significant problem ranging in incidence from 14 to 18%. Drainage following appendectomy is usually determi...

    Authors: Martinus A Beek, Tim S Jansen, Jelle W Raats, Eric L L Twiss, Paul D Gobardhan and Eric J H van Rhede van der Kloot
    Citation: SpringerPlus 2015 4:371
    Content type: Research Published on:

  13. Porcine bocavirus is classified within the genus Bocaparvovirus, family Parvoviridae. Unlike other parvoviruses, the members of genus Bocaparvovirus (bocaparvoviruses) encode an additional open reading frame (NP1...

    Authors: Sung J Yoo, Sun Young Sunwoo, Seong Sik Ko, Sang H Je, Dong Uk Lee and Young S Lyoo
    Citation: SpringerPlus 2015 4:370
    Content type: Short report Published on:

  14. Women with breast cancer may experience symptoms of depression, anxiety, pain, fatigue and sleep disturbances during chemotherapy. However, there are few modalities that address multiple, commonly occurring sy...

    Authors: Debra Lyon, Debra Kelly, Jeanne Walter, Harry Bear, Leroy Thacker and Ronald K Elswick
    Citation: SpringerPlus 2015 4:369
    Content type: Research Published on:

  17. Chronic intussusception, defined as intussusception continuing over 14 days, is rare in children. We herein report a case of chronic ileocolic intussusception caused by the transmural infiltration of diffuse l...

    Authors: Ryuta Saka, Takashi Sasaki, Ikuo Matsuda, Satoko Nose, Masafumi Onishi, Tetsurou Fujino, Hideki Shimomura, Yoshitoshi Otsuka, Noriko Kajimoto, Seiichi Hirota and Takaharu Oue
    Citation: SpringerPlus 2015 4:366
    Content type: Case Study Published on:

  18. There is a significant difference in the mean tumor size between very young breast cancer patients and their elder counterparts. A simple comparison may show obvious prognostic differences. We investigated the...

    Authors: Masujiro Makita, Takehiko Sakai, Akemi Kataoka, Dai Kitagawa, Akiko Ogiya, Hidetomo Morizono, Yumi Miyagi, Kotaro Iijima, Kokoro Kobayashi, Takayuki Kobayashi, Ippei Fukada, Kazuhiro Araki, Shunji Takahashi, Yoshinori Ito, Naoya Gomi, Masahiko Oguchi…
    Citation: SpringerPlus 2015 4:365
    Content type: Research Published on:

  21. Hand, food, and mouth disease (HFMD) is a highly contagious disease caused by enteroviruses infection. It is a health problem in young children under 5 years of age worldwide. The common causative agents are c...

    Authors: Susheera Chatproedprai, Therdpong Tempark, Nasamon Wanlapakorn, Jiratchaya Puenpa, Siriwan Wananukul and Yong Poovorawan
    Citation: SpringerPlus 2015 4:362
    Content type: Case Study Published on:

  23. A novel approach based on fourth order statistics is presented for estimating the parameters of the complex exponential signal model in additive colored Gaussian noise whose autocorrelation function is not kno...

    Authors: Pradip Sircar, Mukesh K Dutta and Sudipta Mukhopadhyay
    Citation: SpringerPlus 2015 4:360
    Content type: Research Published on:

  25. The hepatocyte growth factor (HGF)/c-Met signal pathway is up-regulated in human mesothelioma and suppression of the HGF/c-Met signaling with a competitive inhibitor, NK4 homologous to HGF in the structure, pr...

    Authors: Yuji Tada, Kenzo Hiroshima, Hideaki Shimada, Naoya Morishita, Toshiro Shirakawa, Kunio Matsumoto, Masato Shingyoji, Ikuo Sekine, Koichiro Tatsumi and Masatoshi Tagawa
    Citation: SpringerPlus 2015 4:358
    Content type: Study Protocol Published on:

  26. Single nucleotide polymorphisms (SNPs) in the IL28B gene were shown to have limited utility in predicting response to telaprevir and boceprevir in treatment of chronic HCV infection in clinical trials. Data ou...

    Authors: Giorgio Calisti, Amanda Tavares, Malcolm J Macartney, Adele McCormick, Wendy Labbett, Michael Jacobs, Geoffrey Dusheiko, William M Rosenberg and Tanzina Haque
    Citation: SpringerPlus 2015 4:357
    Content type: Research Published on:

  27. This study observed influenza activity between June 2009 and July 2014 in Thailand, a country in the Northern hemisphere with a tropical climate, and compared the results to activity in the United States (US) ...

    Authors: Slinporn Prachayangprecha, Preeyaporn Vichaiwattana, Sumeth Korkong, Joshua A Felber and Yong Poovorawan
    Citation: SpringerPlus 2015 4:356
    Content type: Research Published on:

  28. This study determined the effects of acute treatment with morphine on the expression of the Oprm1, Oprk1, and Oprd1 genes (which encode μ, κ, and δ receptors, respectively) in the striatum, hypothalamus, and peri...

    Authors: Wesley Soares Cruz, Lucas Assis Pereira, Luana Carvalho Cezar, Rosana Camarini, Luciano Freitas Felicio, Maria Martha Bernardi and Elizabeth Teodorov
    Citation: SpringerPlus 2015 4:355
    Content type: Research Published on:

  29. Multi-domain proteins form the majority of proteins in eukaryotes. During their formation by tandem duplication or gene fusion, new interactions between domains may arise as a result of the structurally-forced...

    Authors: Joana Projecto-Garcia, Didier Jollivet, Jean Mary, François H Lallier, Stephen W Schaeffer and Stéphane Hourdez
    Citation: SpringerPlus 2015 4:354
    Content type: Research Published on:

  30. We investigated whether chronic intravenous administration of l-carnitine could improve myocardial fatty acid imaging in patients on maintenance hemodialysis. We enrolled 72 hemodialysis patients who had impaired...

    Authors: Masato Nishimura, Toshiko Tokoro, Toru Takatani, Nodoka Sato, Masaya Nishida, Tetsuya Hashimoto, Satoru Yamazaki, Hiroyuki Kobayashi and Toshihiko Ono
    Citation: SpringerPlus 2015 4:353
    Content type: Research Published on:

  31. Bottlenose dolphins are known to use signature whistles to identify conspecifics auditorily. However, the way in which they recognize individuals visually is less well known. We investigated their visual recog...

    Authors: Masaki Tomonaga, Yuka Uwano, Sato Ogura, Hyangsun Chin, Masahiro Dozaki and Toyoshi Saito
    Citation: SpringerPlus 2015 4:352
    Content type: Research Published on:

  33. Intraoperative intravascular volume expansion with hydroxyethyl starch-based colloids is thought to be associated with an increased risk of post-craniotomy hemorrhage. Evidence for this association is limited....

    Authors: James A Feix, C Andrew Peery, Tong J Gan, David S Warner, Michael L James, Ali Zomorodi and David L McDonagh
    Citation: SpringerPlus 2015 4:350
    Content type: Research Published on:

  36. To evaluate the modifications of the tumor stage and clinical target volume following a prostate magnetic resonance imaging (MRI) to evaluate the tumor (T) staging, and the clinical benefits for prostate cancer.

    Authors: Shinsaku Yamaguchi, Takayuki Ohguri, Masami Fujii, Katsuya Yahara, Yoshiko Hayashida, Naohiro Fujimoto and Yukunori Korogi
    Citation: SpringerPlus 2015 4:347
    Content type: Research Published on:

  37. To investigate the efficacy and safety of a dipeptidyl peptidase-4 inhibitor, sitagliptin, for treating diabetes mellitus complicated by chronic liver injury.

    Authors: Masahiro Asakawa, Hiroshi Mitsui, Momoko Akihisa, Tetsuo Sekine, Yoshihiro Niitsu, Arisa Kobayashi, Atsuko Miyake, Naoaki Hashimoto, Mitsunobu Kawamura and Yoshihiro Ogawa
    Citation: SpringerPlus 2015 4:346
    Content type: Research Published on:

  38. Arousal theory as discussed within the present paper refers to those mechanisms and neural systems involved in central nervous system activation and more specifically the systems involved in cortical activatio...

    Authors: Clinton S Comer, Patti Kelly Harrison and David W Harrison
    Citation: SpringerPlus 2015 4:345
    Content type: Review Published on:

  39. Heavy metals naturally occur in the marine environment and ecosystems. Due to anthropogenic influence they became common waters and coastal regions pollutants in particular where their concentrations remain ha...

    Authors: Ivana Ratkaj, Paula Žurga, Aleksandar Bulog, Jasna Peter-Katalinić and Sandra Kraljević Pavelić
    Citation: SpringerPlus 2015 4:344
    Content type: Project note Published on:

  40. Sleep deprivation among teens is a major health issue. Only 15% of teens get 8.5 h of sleep on school nights. Sleep deprivation can lead to poor grades, sleepiness and moodiness. We undertook a study to asses...

    Authors: Salim R Surani, Saherish S Surani, Sreevidya Sadasiva, Zoya Surani, Amina Khimani and Sara S Surani
    Citation: SpringerPlus 2015 4:343
    Content type: Research Published on:

  41. ARFs are a family of Ras-related GTP binding proteins, ARF6, in particular, is implicated in cancer invasion and metastasis. However, the role of ARF proteins in prostate cancer have yet to be investigated.

    Authors: Claire Morgan, Paul D Lewis, Lynda Hopkins, Stephanie Burnell, Howard Kynaston and Shareen H Doak
    Citation: SpringerPlus 2015 4:342
    Content type: Research Published on:

  44. Globally, the prevalence of mental illness is on the rise, although few people with psychiatric disorders actually seek mental health care. One under-researched factor that may impact help-seeking behavior fro...

    Authors: Crystal Dea Moore, Casey Schofield, Dalena R M van Rooyen and Lena M C Andersson
    Citation: SpringerPlus 2015 4:339
    Content type: Research Published on:

  45. One of the main pests of commercial rose crops in Colombia is the phytophagous mite Tetranychus urticae Koch. To manage this pest, synthetic chemicals have traditionally been used, some of which are well known to...

    Authors: S Numa, L Rodríguez, D Rodríguez and E Coy-Barrera
    Citation: SpringerPlus 2015 4:338
    Content type: Research Published on:

  46. A wide inventory of molecular markers is nowadays available for individual fingerprinting. Microsatellites, or simple sequence repeats (SSRs), play a relevant role due to their relatively ease of use, their ab...

    Authors: Maria Teresa Dettori, Sabrina Micali, Jessica Giovinazzi, Simone Scalabrin, Ignazio Verde and Guido Cipriani
    Citation: SpringerPlus 2015 4:337
    Content type: Research Published on:

  47. Myocardial infarction animal studies are used to study disease mechanisms and new treatment options. Typically, myocardial infarction (MI) is induced by permanent occlusion of the left anterior descending arte...

    Authors: Vanessa-Leigh van Zuylen, Melina C den Haan, Helene Roelofs, Willem E Fibbe, Martin J Schalij and Douwe E Atsma
    Citation: SpringerPlus 2015 4:336
    Content type: Research Published on:

  48. Mastectomy is effective treatment for ductal carcinoma in situ (DCIS) but some women will develop chest wall recurrence. Most chest wall recurrences that develop after mastectomy are invasive cancer and are as...

    Authors: Jonathan Klein, Iwa Kong, Lawrence Paszat, Sharon Nofech-Mozes, Wedad Hanna, Deva Thiruchelvam, Steven A. Narod, Refik Saskin, Susan J. Done, Naomi Miller, Bruce Youngson, Alan Tuck, Sandip Sengupta, Leela Elavathil, Prashant A. Jani, Elzbieta Slodkowska…
    Citation: SpringerPlus 2015 4:335
    Content type: Research Published on: