Fig. 5From: Association between SNP12 in estrogen receptor α gene and hypospadias: a systematic review and meta-analysisResult of TSA for recessive gene model. Required information size was 2829 patients (α = 5 %, β = 20 %). The blue cumulative Z-curve crosses the inward sloping red trial sequential monitoring boundary for benefit during the second trial but does not reach the required information size. The horizontal green lines illustrate the conventional level of statistical significance (two-sided α = 0.05), which was intersected after the first trial. Square symbol z-score for single study, diamond symbol trial sequential monitoring boundary for benefit score for single studyBack to article page