Endoscopic resection and allografting for benign osteolytic lesions of the calcaneus
© Toepfer et al. 2016
Received: 5 January 2016
Accepted: 27 March 2016
Published: 11 April 2016
Both unicameral bone cysts and intra-osseous lipoma of the calcaneus are rare entities which are mostly diagnosed due to unspecific heel pain, pathologic fracture or as an incidental finding. Minimally-invasive ossoscopy with endoscopic resection of the tumor followed by grafting can potentially minimize risks of open surgery and speed up convalescence. The objective of this study is to present a simple, safe and cost-effective surgical technique for endoscopic surgical treatment of benign osteolytic lesions of the calcaneus.
Description of technique
We present our modifications to previously described techniques of endoscopic curettage with a particular focus on intraosseous lipoma. The key point for grafting is the use of a funnel-shaped ear speculum facilitating the plombage with allogenic cancellous bone chips.
Patients and methods
Between June 2013 and January 2015 ten consecutive patients underwent ossoscopy of the calcaneus. There were 4 cases of intraosseous lipoma and 6 cases of unicameral bone cyst. In a retrospective study, radiological results were analyzed using the Glutting-Classification, functional outcome was recorded with the AOFAS Hindfoot score.
Radiographic follow-up and functional outcome showed good to excellent results. All lesions radiologically classified as “healed”. AOFAS score (max. 100 pts) ranged from 74 to 100 (ø94.4 ± 9.3).
This technique is a simple and safe procedure for benign osteolytic bone lesions of the calcaneus. Compared to its alternatives, grafting with allogenic cancellous bone might prove favourable in this localization for several reasons: Osteointegration, handling, availability and costs. Our preliminary investigations show promising results although further clinical and radiographic results are needed.
KeywordsFoot tumor Unicameral bone cyst Bone tumor Intraosseous lipoma Minimally-invasive surgery Ossoscopy Calcaneal bone cyst Lipoma of bone Simple bone cyst Osteolysis
Treatment recommendations for asymptomatic calcaneal lipoma and unicameral bone cysts are still being discussed controversially. However, surgery is indicated in the presence of pain resistant to conservative treatment methods, impending or pathologic fractures and when a histopathological diagnosis is required for differential diagnoses like aneurysmal bone cyst, giant cell tumor or any other suspected aggressive bone lesion (Ulucay et al. 2009). Depending on clinical and radiographic findings, open biopsy or core needle biopsy versus intralesional tumor resection have to be discussed individually.
The type of intervention for unicameral bone cysts remains controversial (Levy et al. 2015). General treatment options for UBC include curettage in combination with autologous or allogenic grafting, the use of bone substitutes, autologous bone-marrow injection and various methods of cyst decompression including cannulated screws or a cannulated hydroxyapatite pin (Chang et al. 2002; Levy et al. 2015; Pogoda et al. 2004; Shirai et al. 2015; Yildirim et al. 2011). Nowadays most of these techniques can be performed percutaneously or minimally-invasive. For the weight bearing lower extremity, especially for calcaneal localizations, special considerations have to be taken into account, though. In 2015 Levy et al. conducted the first systematic review on the treatment of unicameral bone cysts of the calcaneus. His results clearly demonstrated that all patients who underwent operative curettage with bone substitute—whether autograft or allograft—enjoyed a statistically significant improvement in heel pain and demonstrated the best outcomes in his review regarding osteointegration and rate of recurrence (Levy et al. 2015). Curettage with bone augmentation demonstrated significant improvements over curettage with cannulated-screw placement. No information was available on endoscopic procedures with minimally-invasive curettage and bone grafting. Moreover, curettage with bone graft substitutes showed generally better outcomes than steroid injections (Cho et al. 2007; Glaser et al. 1999; Levy et al. 2015; Mainard and Galois 2006). Standard surgical procedures such as open curettage and autologous bone grafting can entail non-negligible risks and complications, though. Potential donor site morbidity is a major disadvantage of autologous bone grafting (Calori et al. 2014; Schaaf et al. 2010). Conventional open curettage and plombage of a benign lytic calcaneal bone lesion are usually performed through a lateral surgical approach with a longitudinal or L-shaped skin incision and a fenestration of the lateral cortical wall of the calcaneus. Prolonged wound healing and iatrogenic damage of the sural nerve are well-known complications for this localization (Ding et al. 2013; Zhang et al. 2015). Furthermore, a large fenestration can weaken the cortical structures of the calcaneus additionally. Advantages of MIS (minimally-invasive surgery) include less pain, less scarring and better aesthetical results as only a small incision and limited dissection is necessary (Mainard and Galois 2006; Yildirim et al. 2011). Our hypothesis for this procedure is that endoscopic resection and allografting for benign osteolytic lesions of the calcaneus minimizes risks associated with conventional open surgery and autologous grafting whilst offering all the benefits of a minimally-invasive technique and of the traditional treatment with open curettage and grafting in terms of good osteointegration and low rates of recurrence. Endoscopic curettage of solitary calcaneal cysts with different forms of grafting has been reported before with good results (Innami et al. 2011; Yildirim et al. 2011). To the best of our knowledge, endoscopic treatment for intraosseous lipoma (IOL) of the calcaneus has only been reported as a case report so far (Futani et al. 2007; Muramatsu et al. 2014). Compared to autografts allogenic bone is easily available and almost unlimited in supply. Compared to injectable bone substitute, percutaneous grafting with allogenic cancellous bone chips can be exhausting and time-consuming, though. Costs and osteointegration might still favour the use of allografts. We present our modification to previously described techniques of endoscopic curettage with particular focus on IOL and allogenic cancellous bone grafting. The key point of the procedure is the use of a funnel-shaped ear speculum facilitating the filling of the bone cavity with allogenic cancellous bone chips. The objective of this study is to present a simple, safe and cost-effective surgical technique for ossoscopic treatment of benign osteolytic lesions of the calcaneus.
Partial weight bearing is advised for 6 weeks and impact sports should be avoided for a minimum of 3 months postop. A radiologic follow-up is performed 6 and 12 weeks and 12 months postop with plain radiography. Repeated MRI imaging after complete resection of lipoma of bone is usually not required as recurrence is very rare (Fletcher et al. 2013).
Patients and methods
Patient characteristics and operation time
Age at diagnosis (years)/gender
Operation time (h)
Mean operation time in our study group was 71.5 ± 22.2 min (min. 35, max. 103 min) (Table 1). A seroma with prolonged superficial wound healing developed in one patient. Repeated blood tests and a smear test of the wound were able to rule out wound infection. No sural nerve irritations or other complications were noticed. All patients were allowed full weight bearing and were able to return to everyday activities without orthopaedic aids 6 weeks after surgery. Radiographic follow-up showed desirable bony consolidation in all cases. There was no persistent cyst and no recurrence. According to the classification of Glutting and Chang, all ten lesions radiologically classified as “healed” with a cyst filled by a formation of new bone with or without small static, radiolucent areas less than 1 cm in size (Chang et al. 2002). Thus, the overall radiological success rate was 100 %. AOFAS score (max. 100 pts) ranged from 74 to 100 (ø94.4 ± 9.3). Within this score, results for pain scored ø 36.6 ± 7.0 (min. 20, max. 40 pts.) with 40pts for no pain and 0pts for constant pain.
At the current time, no other studies involving endoscopic treatment for both IOL and UBC of the calcaneus are available for comparison. In the literature study designs for endoscopic treatment of calcaneal UBC are heterogenous regarding grafting, radiological evaluation and functional testing. Innami et al. (2011) reported similar functional results with an overall AOFAS of ø98.0 ± 4.2 pts and pain score of ø39.0 ± 3.2 for his patients. Grafting was performed with an injectable bone substitute, though. All of their patients returned to their initial levels of sports activities within 8 weeks (Innami et al. 2011).
Mean operation time in Yildirim’s study was significantly shorter than in our study (ø45 min) (Yildirim et al. 2011). No information on intraoperative local adjuvant therapy (e.g. 95 % ethanol) was found in his work. The operation time in our patients diminished significantly over the course of time with more experience in the ossoscopic procedure and after the introduction of the speculum. We experienced that meticulous ossoscopic curettage of IOL with resection of dystrophic calcifications was more time-consuming than in UBC. Operation time of our procedure might be additionally cut down by the use of injectable bone substitute but, in our experience, osteointegration is inferior to allogenic bone, adverse effects have been reported (Lee et al. 2002) and, last but not least, cost-effectiveness is mostly disadvantageous (Kurien et al. 2013). Compared to autologous bone or bone substitute, allogenic bone is easily available, affordable and can offer good osteoinductive and osteoconductive properties (Oryan et al. 2014). The major advantage is to avoid sacrificing host tissue and the challenges of donor site morbidity (Greenwald et al. 2001). Disadvantages of allogenic bone grafting include that harvesting and conservation of allogenic grafts might be a limiting factor in some countries (Nandi et al. 2010; Pruss 2007). Moreover, there are two theoretical concerns regarding the use of bone allografts: Antigenicity and the risk of disease transmission. With modern means of tissue processing these risks seem to be almost negligible (Grover et al. 2011; Nasr et al. 2000).
The systematic review conducted on treatment options for calcaneal bone cysts by Levy et al. found no clear distinction between autografting and allografting regarding a difference in pre- and post-operative heel pain. Although cysts treated with autografts consolidated on radiography at a significantly greater rate than those treated with allografts, no recurrences, complications or reactions suggestive of graft rejection were recorded in either group (Levy et al. 2015).
Converted to USD the price for the allogenic cancellous bone that is applied in our patients is 323$ USD for 10 ml (DIZG©, Germany). Alternatively, injectable bone substitutes that were used in our clinic for similar indications previously included different combinations of calcium sulphate, calcium phosphate and hydroxyapatite (Cerament/Bonesupport©, 644$ USD for 10 ml; Pro-Dense/Wright Medical©, 497$ USD for 10 ml; Arthrex/QuickSet©, 456$ USD for 5 ml or 520$ USD for 8 ml).
In our experience, the use of calcium phosphate cement, as proposed by other authors (Innami et al. 2011), is not advisable for permanent use in all localizations. This applies all the more for young patients as encountered in these entities. Bone cement, either (potentially) bioresorbable or not, might eventually thin-out the surrounding cortices in a non-cancellous environment. This phenomenon is well-known in other areas where bone cement is being used for temporary filling after tumor resection (e.g. distal radius in cases of giant cell tumor) (Gaston et al. 2011). Long-term results will need to prove its safety regarding osteointegration and potential diminution of bone stock. Osseous integration of the bone graft seems not to be sped-up by an ossoscopic procedure compared to traditional open procedures (Yildirim et al. 2011). In either case, partial weight bearing is advised for a minimum of 6 weeks postop. In contrast, the instant strength of most injectable bone substitutes could allow for full weight bearing immediately after the surgery.
After endoscopic resection of IOL histopathological confirmation of the diagnosis can prove to be difficult. Continous irrigation is needed to obtain a clear vision of the cavity and all lipomatous tissue will be washed out promptly. Where present, dystrophic calcifications can be extracted and sent for histopathological analysis. Alternatively, a specimen of lipomatous intra-osseous tissue can be saved for further analysis once the first portal for ossoscopy has been established. Without endoscopic vision and irrigation, a percutaneous biopsy can produce enough representative tissue for a precise histopathological diagnosis in most cases. For UBC, the inner lining of the bone cavity will not be washed out by endoscopic irrigation and samples can easily be saved for further diagnostics by ossoscopic resection.
We encountered one postoperative complication with a seroma and delayed wound healing in our follow-up, accounting for a 10 % complications rate (1/10). With the same number of patients included in his follow-up (n = 10), Innami et al. (2011) did not find any complications related to the surgery consisting of endoscopic resection and calcium phosphate cement plombage for calcaneal UBC. The same applies to a study performed by Yildirim et al. (2011) comparing open versus endoscopic curettage and grafting. Here, no complications were recorded in the group with percutaneous endoscopic curettage. Compared to these studies the 10 % complication rate in our series seems relatively high and might be explained by the small sample size of both Innami’s (10 patients), Yildirim’s (13 patients) and our own study group (10 patients). For open procedures, some authors report higher complications rates (Yildirim et al. 15.4 %, Yildirim et al. 2011), others no complications whatsoever (Park et al. 2008; Polat et al. 2009).
Limitations of this study include the small sample number, the short follow-up (ø19.8 m) and the retrospective study design without control cases. A randomized controlled study with a larger sample number will be necessary for the future comparing injectable bone substitute and allogenic cancellous bone grafting for ossoscopic treatment of calcaneal UBC and IOL. The nature of calcaneal UBC and IOL, often unsymptomatic and rare, will hinder this project, though.
We recommend that small, symptomatic benign osteolytic lesions of the calcaneus with a diameter of 3 cm or less in the sagittal plane are better suited for mini-open surgery as standard instruments for ossoscopy will interfere with each other and complicate handling. Moreover, both portals can brake out and form one large opening due to their close proximity to each other. Alternatively, the use of a 2.7 mm scope is a viable option for very small osteolytic bone lesions.
Musculoskeletal tumors and tumor-like lesions of the calcaneus are rare but have to be taken into consideration for chronic heel pain. Once a lytic bone lesion is recognized on plain radiography, calcaneal lipoma of bone and unicameral bone cyst represent one of several entities that must be further investigated by MRI (Pogoda et al. 2004). To avoid pathologic fractures, large lesions are recommended for prophylactic surgical therapy, even if the patient is free of symptoms (Pogoda et al. 2004). Traditionally, symptomatic cases of IOL or UBC were treated with open curettage and bone grafting. Compared to open curettage with a longitudinal incision parallel to the planta pedis or a classic L-shaped incision, minimally-invasive ossoscopy can diminish the risk of impaired wound healing and speed-up superficial wound healing (Yildirim et al. 2011). Several studies demonstrated that minimally-invasive ossoscopy can offer a safe alternative to open surgical procedures (Futani et al. 2007; Innami et al. 2011; Mainard and Galois 2006; Yildirim et al. 2011). Compared to endoscopic resection and filling with an injectable bone substitute, allogenic bone grafting is both less expensive (Kurien et al. 2013) and might prove biologically superior. As a modification of previously reported procedures, the use of an ear speculum, as described in our technique, can facilitate the process of grafting with cancellous bone chips.
AT introduced the technique, conceived the study, planned and carried out all surgical procedures of the patients and prepared the manuscript, UL participated with the literature review, preparation of the figures and prepared the manuscript, LG has been involved in drafting the manuscript and revising it critically for important intellectual content, FL was crucial for the revision of the manuscript and largely contributed to the final version, NH was involved in the clinical follow-up of the patient and helped to draft the manuscript. AT and UL contributed equally to this work and share first author. All authors read and approved the final manuscript.
Rüdiger von Eisenhart-Rothe supported the authors in their studies, which is gratefully acknowledged. This study was partially funded by the Wilhelm-Sander Foundation, which is a charitable, non-profit foundation whose purpose is to promote cancer research.
The ethical review committee of our institution (Technical University Munich) approved the study.
The work was performed at the Clinic for Orthopaedics and Orthopaedic Sports Medicine, Technical University Munich.
The authors declare that they have no competing interests.
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- Calori GM, Colombo M, Mazza EL, Mazzola S, Malagoli E, Mineo GV (2014) Incidence of donor site morbidity following harvesting from iliac crest or RIA graft. Injury 45(Suppl 6):S116–S120View ArticleGoogle Scholar
- Chang CH, Stanton RP, Glutting J (2002) Unicameral bone cysts treated by injection of bone marrow or methylprednisolone. J Bone Joint Surg Br 84:407–412View ArticleGoogle Scholar
- Cho HS, Oh JH, Kim HS, Kang HG, Lee SH (2007) Unicameral bone cysts: a comparison of injection of steroid and grafting with autologous bone marrow. J Bone Joint Surg Br 89:222–226View ArticleGoogle Scholar
- De Wilde V, De Maeseneer M, Lenchik L, Van Roy P, Beeckman P, Osteaux M (2004) Normal osseous variants presenting as cystic or lucent areas on radiography and CT imaging: a pictorial overview. Eur J Radiol 51:77–84View ArticleGoogle Scholar
- Diard F, Hauger O, Moinard M, Brunot S, Marcet B (2007) Pseudo-cysts, lipomas, infarcts and simple cysts of the calcaneus: are there different or related lesions? JBR-BTR: organe de la Societe royale belge de radiologie. 90:315–324Google Scholar
- Ding L, He Z, Xiao H, Chai L, Xue F (2013) Risk factors for postoperative wound complications of calcaneal fractures following plate fixation. Foot Ankle Int 34:1238–1244View ArticleGoogle Scholar
- Fletcher C, Bridge JA, Hogendoorn PCW, Mertens F (2013) World health organization classification of tumours. WHO, LyonGoogle Scholar
- Freyschmidt JOH, Jundt G (2010) Knochenutmoren mit Kiefertumoren: Klinik-Radiologie-Pathologie. Springer, BerlinView ArticleGoogle Scholar
- Futani H, Fukunaga S, Nishio S, Yagi M, Yoshiya S (2007) Successful treatment of bilateral calcaneal intraosseous lipomas using endoscopically assisted tumor resection. Anticancer Res 27:4311–4314Google Scholar
- Gaston CL, Bhumbra R, Watanuki M, Abudu AT, Carter SR, Jeys LM, Tillman RM, Grimer RJ (2011) Does the addition of cement improve the rate of local recurrence after curettage of giant cell tumours in bone? J Bone Joint Surg Br 93:1665–1669View ArticleGoogle Scholar
- Glaser DL, Dormans JP, Stanton RP, Davidson RS (1999) Surgical management of calcaneal unicameral bone cysts. Clin Orthop Relat Res 360:231–237View ArticleGoogle Scholar
- Greenwald AS, Boden SD, Goldberg VM, Khan Y, Laurencin CT, Rosier RN, American Academy of Orthopaedic Surgeons. The Committee on Biological I (2001) Bone-graft substitutes: facts, fictions, and applications. J Bone Joint Surg Am 83-A(Suppl 2 Pt 2):98–103Google Scholar
- Grover V, Kapoor A, Malhotra R, Sachdeva S (2011) Bone allografts: a review of safety and efficacy. Indian J Dent Res 22:496View ArticleGoogle Scholar
- Innami K, Takao M, Miyamoto W, Abe S, Nishi H, Matsushita T (2011) Endoscopic surgery for young athletes with symptomatic unicameral bone cyst of the calcaneus. Am J Sports Med 39:575–581View ArticleGoogle Scholar
- Kurien T, Pearson RG, Scammell BE (2013) Bone graft substitutes currently available in orthopaedic practice: the evidence for their use. Bone Joint J 95-B:583–597View ArticleGoogle Scholar
- Lee GH, Khoury JG, Bell JE, Buckwalter JA (2002) Adverse reactions to OsteoSet bone graft substitute, the incidence in a consecutive series. Iowa Orthop J 22:35–38Google Scholar
- Levy DM, Gross CE, Garras DN (2015) Treatment of unicameral bone cysts of the calcaneus: a systematic review. J Foot Ankle Surg 54:652–656View ArticleGoogle Scholar
- Mainard D, Galois L (2006) Treatment of a solitary calcaneal cyst with endoscopic curettage and percutaneous injection of calcium phosphate cement. J Foot Ankle Surg 45:436–440View ArticleGoogle Scholar
- Muramatsu K, Tominaga Y, Hashimoto T, Taguchi T (2014) Symptomatic intraosseous lipoma in the calcaneus. Anticancer Res 34:963–966Google Scholar
- Nandi SK, Roy S, Mukherjee P, Kundu B, De DK, Basu D (2010) Orthopaedic applications of bone graft and graft substitutes: a review. Indian J Med Res 132:15–30Google Scholar
- Nasr HF, Aichelmann-Reidy ME, Yukna RA (2000) Bone and bone substitutes. Periodontol 1999(19):74–86Google Scholar
- Oryan A, Alidadi S, Moshiri A, Maffulli N (2014) Bone regenerative medicine: classic options, novel strategies, and future directions. J Orthop Surg Res 9:18View ArticleGoogle Scholar
- Park IH, Micic ID, Jeon IH (2008) A study of 23 unicameral bone cysts of the calcaneus: open chip allogeneic bone graft versus percutaneous injection of bone powder with autogenous bone marrow. Foot Ankle Int 29:164–170View ArticleGoogle Scholar
- Pogoda P, Priemel M, Catala-Lehnen P, Gebauer M, Rupprecht M, Adam G, Rueger JM, Amling M (2004a) Simple bone cysts of the calcaneus. Differential diagnosis and therapy. Der Unfallchirurg 107(680–684):686–688Google Scholar
- Pogoda P, Priemel M, Linhart W, Stork A, Adam G, Windolf J, Rueger JM, Amling M (2004b) Clinical relevance of calcaneal bone cysts: a study of 50 cysts in 47 patients. Clin Orthop Relat Res 424:202–210View ArticleGoogle Scholar
- Polat O, Saglik Y, Adiguzel HE, Arikan M, Yildiz HY (2009) Our clinical experience on calcaneal bone cysts: 36 cysts in 33 patients. Arch Orthop Trauma Surg 129:1489–1494View ArticleGoogle Scholar
- Pruss A, von Versen R (2007) Influence of European regulations on quality, safety and availability of cell and tissue allografts in Germany. Handchir Mikrochir Plast Chir 39:81–87View ArticleGoogle Scholar
- Schaaf H, Lendeckel S, Howaldt HP, Streckbein P (2010) Donor site morbidity after bone harvesting from the anterior iliac crest. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 109:52–58View ArticleGoogle Scholar
- Shirai T, Tsuchiya H, Terauchi R, Tsuchida S, Mizoshiri N, Ikoma K, Fujiwara H, Miwa S, Kimura H, Takeuchi A, Hayashi K, Yamamoto N, Kubo T (2015) Treatment of a simple bone cyst using a cannulated hydroxyapatite pin. Medicine 94:e1027View ArticleGoogle Scholar
- Sirry A (1951) The pseudo-cystic triangle in the normal os calcis. Acta Radiol 36:516–520View ArticleGoogle Scholar
- Sung AD, Anderson ME, Zurakowski D, Hornicek FJ, Gebhardt MC (2008) Unicameral bone cyst: a retrospective study of three surgical treatments. Clin Orthop Relat Res 466:2519–2526View ArticleGoogle Scholar
- Ulucay C, Altintas F, Ozkan NK, Inan M, Ugutmen E (2009) Surgical treatment for calcaneal intraosseous lipomas. Foot 19:93–97View ArticleGoogle Scholar
- Weger C, Frings A, Friesenbichler J, Grimer R, Andreou D, Machacek F, Pfeiffenberger K, Liegl-Atzwanger B, Tunn PU, Leithner A (2013) Osteolytic lesions of the calcaneus: results from a multicentre study. Int Orthop 37:1851–1856View ArticleGoogle Scholar
- Weinfeld GD, Yu GV, Good JJ (2002) Intraosseous lipoma of the calcaneus: a review and report of four cases. J Foot Ankle Surg 41:398–411View ArticleGoogle Scholar
- Yildirim C, Akmaz I, Sahin O, Keklikci K (2011) Simple calcaneal bone cysts: a pilot study comparing open versus endoscopic curettage and grafting. J Bone Joint Surg Br 93:1626–1631View ArticleGoogle Scholar
- Zhang W, Chen E, Xue D, Yin H, Pan Z (2015) Risk factors for wound complications of closed calcaneal fractures after surgery: a systematic review and meta-analysis. Scand J Trauma Resusc Emerg Med 23:18View ArticleGoogle Scholar