Figure 6
From: Interactions of antiparasitic sterols with sterol 14α-demethylase (CYP51) of human pathogens
![Figure 6](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2F2193-1801-3-679/MediaObjects/40064_2014_Article_1378_Fig6_HTML.jpg)
The lowest energy pose of 2,3-bis-(4-hydroxybenzoyl) derivative of sebiferenic acid is predicted to interact via hydrogen bonding with the heme co-factor in the active site of T. cruzi CYP51. The hydrophobic amino acid residues in the active site offer a favorable binding patch for esterified sterols. The molecular surface diagram is shown in Additional file 1: Figure S4.