- Open Access
Volume-rendered hemorrhage-responsible arteriogram created by 64 multidetector-row CT during aortography: utility for catheterization in transcatheter arterial embolization for acute arterial bleeding
SpringerPlus volume 3, Article number: 67 (2014)
Aortography for detecting hemorrhage is limited when determining the catheter treatment strategy because the artery responsible for hemorrhage commonly overlaps organs and non-responsible arteries. Selective catheterization of untargeted arteries would result in repeated arteriography, large volumes of contrast medium, and extended time. A volume-rendered hemorrhage-responsible arteriogram created with 64 multidetector-row CT (64MDCT) during aortography (MDCTAo) can be used both for hemorrhage mapping and catheter navigation. The MDCTAo depicted hemorrhage in 61 of 71 cases of suspected acute arterial bleeding treated at our institute in the last 3 years. Complete hemostasis by embolization was achieved in all cases. The hemorrhage-responsible arteriogram was used for navigation during catheterization, thus assisting successful embolization. Hemorrhage was not visualized in the remaining 10 patients, of whom 6 had a pseudoaneurysm in a visceral artery; 1 with urinary bladder bleeding and 1 with chest wall hemorrhage had gaze tamponade; and 1 with urinary bladder hemorrhage and 1 with uterine hemorrhage had spastic arteries. Six patients with pseudoaneurysm underwent preventive embolization and the other 4 patients were managed by watchful observation. MDCTAo has the advantage of depicting the arteries responsible for hemoptysis, whether from the bronchial arteries or other systemic arteries, in a single scan. MDCTAo is particularly useful for identifying the source of acute arterial bleeding in the pancreatic arcade area, which is supplied by both the celiac and superior mesenteric arteries. In a case of pelvic hemorrhage, MDCTAo identified the responsible artery from among numerous overlapping visceral arteries that branched from the internal iliac arteries. In conclusion, a hemorrhage-responsible arteriogram created by 64MDCT immediately before catheterization is useful for deciding the catheter treatment strategy for acute arterial bleeding.
The concept of installing a CT scanner and angiography unit in the same room, utilizing a shared tabletop, originated in Japan for conducting CT during arterial portography (CTAP) and CT hepatic arteriography (CTHA) (Matsui et al. ; Hayashi et al. ; Honda et al. ; Kitao et al. ; Matsui et al. ). The combined facility is termed angio CT or interventional radiology CT (IVRCT). Angio CT is particularly useful for investigating the hemodynamics of small hepatocellular carcinoma (HCC), and has enabled improved understanding of the growth process from early HCC to mature HCC (Matsui et al. ; Hayashi et al. ; Honda et al. ; Kitao et al. ; Matsui et al. ; Lee et al. ). Hepatoma-feeding arteriograms that were created by MDCT during aortography (MDCTAo) were previously reported to be displayed on the monitor in the angiography room and used for catheterization of feeding arteries to a HCC (Minamiguchi et al. ). Accordingly, it should be possible to apply MDCTAo to patients with acute arterial bleeding, to map the hemorrhage site and to navigate catheterization to the artery responsible for hemorrhage.
The purpose of the present paper is to introduce the method for creating a hemorrhage-responsible arteriogram by MDCTAo, and to describe the clinical usefulness of the hemorrhage-responsible arteriogram for catheter treatment of acute arterial bleeding.
Interventional radiology multidetector-row CT
We used a 64 multidetector-row CT (64MDCT) scanner installed in an angiography room. The scanner and the angiography suite have a common tabletop, removing the need to transfer the patient between procedures. A 64MDCT scanner (0.5 sec/rotation, pitch factor 1.484; INFX 8000-C Aquilion CX, Toshiba Medical, Tochigi, Japan) with collimation and detector thickness each of 0.5 mm was used for MDCTAo. The arterial scans were reconstructed with slice thickness and slice interval each of 0.5 mm, and maximum intensity projection (MIP) and volume-rendered (VR) images were produced instantly using a three-dimensional (3D) workstation (ZIO Station, ZIO Soft, Tokyo, Japan). Tube voltage was 120 kVp with tube mA determined automatically.
The scanning field is determined to include the hemorrhage and the artery responsible for hemorrhage. The position of the catheter tip and the amount of contrast medium are adjusted according to the scanning field. We routinely use three protocols: for thoracic arterial bleeding, abdominal arterial bleeding, and pelvic arterial bleeding.
MDCT during thoracic aortography (MDCT-TA) for thoracic arterial bleeding
We developed a scanning protocol for MDCT-TA for hemoptysis based on our clinical experience. Briefly, scans were obtained from the level of the upper margin of the 7th cervical vertebra to the lower margin of the 1st lumbar vertebra. MDCT-TA scanning was scheduled to start with a contrast medium (CM) injection rate of 10 mL/sec, using a 4 F pigtail catheter as used for thoracic aortography (TA; 90 cm, Medikit, Miyazaki, Japan), positioned at the ascending aorta. In TA of each of 10 patients with hemoptysis, a total of 30 mL of CM was injected at a rate of 10 mL/sec, and the mean time from initiation of the CM injection to the end of peak density in the descending aorta at the level of the diaphragm was approximately 5 sec. Therefore, MDCT scanning during TA could be delayed for 5 sec after the initiation of CM injection. The concentration of CM used was 150 mg iodine/ml. We no longer conduct conventional TA for thoracic arterial bleeding since the development of this protocol.
MDCT during abdominal aortography (MDCT-AA) for abdominal arterial bleeding
The protocol used for MDCT-AA follows that for detecting the feeding artery for hepatocellular carcinoma described in a previous report (Minamiguchi et al. ). In short, a 3 F pigtail catheter (70 cm, Medikit) was advanced so that its tip was positioned at the level of the tracheal bifurcation. Although the scan range varied depending on the suspected site of acute arterial bleeding, scans were mostly obtained from the level of the diaphragm to the level of the aortic bifurcation. A total of 90 ml of 2-fold diluted CM (Iopamidol 300, Bracco, Milano, Italy) was injected via the pigtail catheter at a rate of 9 ml/sec for 10 sec. MDCT scanning was initiated at 7 sec from the beginning of CM injection at maximum expiration.
MDCT during pelvic arteriography (MDCT-PA) for pelvic arterial bleeding
A pigtail catheter was advanced to the upper level of the renal arteries in order to include the branching of the ovarian or testicular arteries. Scans were obtained from the level superior to the renal arteries to the lower border of the ischium. A total of 80 ml of 2-fold diluted CM (Iopamidol 300) was injected via the pigtail catheter at a rate of 8 ml/sec for 10 sec. MDCT scanning was initiated at 7 sec from the beginning of CM injection at maximum expiration.
Creation of hemorrhage-responsible arteriogram
The hemorrhage-responsible arteriogram is created on the same basis as that reported for a hepatoma-feeding arteriogram (Minamiguchi et al. ). In short, the hemorrhage-responsible arteriogram using MDCTAo is synthesized using three basic VR images: a background bone VR image, an aorta–branch artery VR image, and a hemorrhage–responsible artery VR image. The background bone VR image is produced by deleting all components except the vertebrae and dorsal ribs from the axial MIP image. The aorta–branch artery VR image is produced by deleting all of the bone and cartilage components from the axial MIP image, leaving the aorta, visceral arteries, and visceral organs.
The hemorrhage-responsible artery VR image is produced by marking the hemorrhage, pseudoaneurysm and/or new vessels, and then identifying the responsible arteries. After identification, extension software (ZIO station) automatically connects the responsible artery to the branch artery arising from the aorta, to create a hemorrhage-responsible artery VR image.
In MDCT-TA for hemoptysis, the hemoptysis-responsible VR image was produced by following the path of newly dilated vessels surrounding the bronchus and/or stain corresponding to the inflammation or bleeding. The image was then extended to the aorta–branch artery VR image.
In MDCT-AA for acute abdominal artery bleeding, extravasation of contrast medium and the surrounding area was first detected, the artery responsible for extravasation was identified, and a hemorrhage-responsible artery VR image was then created.
In MDCT-PA for pelvic artery bleeding, we used the subtraction method to obtain a background bone VR image and an aorta to branch artery VR image because this region is relatively unaffected by respiration movement. Specifically, unenhanced CT and MDCT-PA were obtained sequentially in approximately 15 sec during the same breath-hold. A background bone VR image was obtained from the unenhanced CT, and an aorta–branch artery VR image was instantly obtained by subtracting the entire unenhanced CT images from the entire MDCT-PA images. This subtraction method accelerated the production process. A hemorrhage-responsible VR image was produced using the same method as that described above, and extended to produce an aorta–branch artery VR image.
Application of CT during aortography for acute arterial bleeding
In the last 3 years at our institute, 71 patients suspected of having acute arterial bleeding underwent MDCTAo, using MDCT installed in the angiography room. Because most patients were in a critical state of shock, receiving continuous blood transfusion and requiring emergent hemostasis by embolization, CT angiography via the venous route was not always performed. Most patients retained consciousness and could perform breath holding. We generally did not conduct MDCTAo in unresponsive patients. However, when we did perform MDCTAo on unconscious, ventilated patients, the respirator was used to perform breath holding. No patients with pelvic fractures were included in this series, except one patient who had multiple fractures of bilateral iliac, ischial and pubic bones, causing hemorrhagic shock. Of the 71 patients, 69 received MDCTAo, and 2 received CT during superior mesenteric arteriography because the responsible arteries were already known to branch from the superior mesenteric artery. The origins of the acute arterial bleeding in the 71 patients were as follows: hemoptysis (n = 27); hemothorax (n = 2); bleeding post-pancreatectomy (n = 12); intraperitoneal bleeding (n = 3); gastrointestinal bleeding (n = 6); retroperitoneal bleeding (n = 9); uterine bleeding (n = 3); bleeding into the urinary bladder, (n = 3); pelvic fracture (n = 1); intra-pelvic hematoma (n = 1); and subcutaneous hematoma on the trunk (n = 4).
The arteries responsible for hemorrhage were visualized and treated in 61 of the 71 patients. The embolic materials used were gelatin sponge particles (GSP) in 38 patients, n-butyl cyanoacrylate (NBCA) in 10 patients, NBCA plus microcoils in 1 patient, and microcoils in 9 patients. Of 12 patients with bleeding post-pancreatectomy, 3 cases of pseudoaneurysm at the superior mesenteric artery trunk were treated by stent-graft. Hemorrhage was not visualized in the remaining 10 patients, of whom 6 had a pseudoaneurysm in a visceral artery; 1 with urinary bladder bleeding and 1 with chest wall hemorrhage had gaze tamponade; and 1 with urinary bladder hemorrhage and 1 with uterine hemorrhage had spastic arteries. Six patients with pseudoaneurysm underwent preventive embolization and the other 4 patients were managed by watchful observation.
Advantages of hemorrhage-responsible arteriogram in catheterization for acute arterial bleeding
Rapid hemostasis is essential in emergent acute arterial bleeding (Yonemitsu et al. ). It is desirable to detect the artery responsible for hemorrhage quickly, using the smallest possible volume of CM. It is difficult to compare CT angiography and MDCTAo in terms of their ability to detect hemorrhage because most patients in the present study did not receive CT angiography via the venous route. CTAo was conducted to investigate both the extravasation and the responsible artery for hemorrhage. Conventionally, the artery suspected to be responsible for hemorrhage is catheterized after aortography; however, it is sometimes difficult to detect the responsible artery for hemorrhage because of overlapping of the vessels. If selective arteriography reveals negative findings for hemorrhage for the suspected artery, then another artery is catheterized, followed by repeated angiography. This process is time consuming, requires a large volume of CM, and places a high radiation burden on the patient. In contrast, the single scan obtained with MDCTAo enables investigation of all arteries, even if multiple arteries are responsible for hemorrhage, and can demonstrate whether the bronchial arteries or arteries from another system (e.g., the internal thoracic, lateral thoracic, or inferior phrenic arteries) are responsible for hemoptysis (Figures 1 and 2) (Ziyawudong et al. ; Hartmann et al. ; Bruzzi et al. ; Remy-Jardin et al. ).
MDCTAo is especially useful for detecting hemorrhage in the region of the pancreatic head and for identifying arterial supply from the celiac artery and/or superior mesenteric artery (Figures 3 and 4) (Izaki et al. ). Furthermore, although overlapping with other contrast-stained organs causes difficulties in identifying extravasation of CM in angiography, MDCTAo resolves this problem (Figures 3, 4 and 5). In a case of pelvic hemorrhage in which the artery responsible for hemorrhage had to be identified from among several visceral arteries branching from internal iliac arteries, MDCTAo could identify and map the artery responsible for hemorrhage. In navigation for catheterization, the image could be rotated to the most helpful view for catheter insertion (Figures 6 and 7). These examples show that interventional radiologists can use a hemorrhage-responsible arteriogram in various situations to navigate to the target responsible artery. MDCTAo accelerates the process of deciding the catheter treatment strategy at the point of investigating the responsible artery, because the hemorrhage-responsible arteriogram enables identification of the responsible artery and its connection to the aortic branch artery. MDCTAo with 64MDCT can improve speed and reliability in treatment of acute arterial bleeding.
It takes 5–10 min to create a hemorrhage-responsible arteriogram, which is a long time in the situation of acute arterial bleeding. Although this period can be used to exchange the pigtail catheter for the pre-shaped catheter, insert the microcatheter, and bend the micro-guidewire tip, it would be ideal to view the hemorrhage-responsible arteriogram on the display without delay. This could be achieved by development of software that could create a catheter navigation image within a few minutes. Another limitation is that MDCTAo cannot depict hemorrhage when acute arterial bleeding has temporarily ceased. Furthermore, when MDCTAo depicts hemorrhage in the small intestine, the hemorrhage-responsible arteriogram does not reflect the true hemorrhage site for catheterization if the small intestine has moved after scanning, as is common.
In conclusion, although having limitations, we found that a hemorrhage-responsible arteriogram created by 64MDCT immediately before catheterization is useful for devising the catheter treatment strategy in acute arterial bleeding.
Article notes: The contents of this manuscript were presented as a luncheon seminar at the International Abdominal Radiological Meeting, 2013, held in Taiwan, and as a special lecture at the 2013 New Technology International Forum of Interventional Radiology and Imaging Diagnosis, held in NanChon, China.
Bruzzi JF, Rémy-Jardin M, Delhaye D, et al.: Multi-detector row CT of hemoptysis. Radiographics 2006, 26: 3-22. 10.1148/rg.261045726
Hartmann IJ, Remy-Jardin M, Menchini L, et al.: Ectopic origin of bronchial arteries: assessment with multidetector helical CT angiography. Eur Radiol 2007, 17: 1943-1953. 10.1007/s00330-006-0576-8
Hayashi M, Matsui O, Ueda K, et al.: Progression to hypervascular hepatocellular carcinoma: correlation with intranodular blood supply evaluated with CT during intraarterial injection of contrast material. Radiology 2002, 225: 143-149. 10.1148/radiol.2251011298
Honda H, Tajima T, Taguchi K, et al.: Recent developments in imaging diagnostics for HCC: CT arteriography and CT arterioportography evaluation of vascular changes in premalignant and malignant hepatic nodules. J Hepatobiliary Pancreat Surg 2000, 7: 245-251. 10.1007/s005340070044
Izaki K, Yamaguchi M, Kawasaki R, et al.: N-butyl cyanoacrylate embolization for pseudoaneurysms complicating pancreatitis or pancreatectomy. J Vasc Interv Radiol 2011, 22: 302-308. 10.1016/j.jvir.2010.11.011
Kitao A, Zen Y, Matsui O, Gabata T, Nakanuma Y: Hepatocarcinogenesis: multistep changes of drainage vessels at CT during arterial portography and hepatic arteriography–radiologic-pathologic correlation. Radiology 2009, 252: 605-614. 10.1148/radiol.2522081414
Lee KH, Sung KB, Lee DY, et al.: Transcatheter arterial chemoembolization for hepatocellular carcinoma: anatomic and hemodynamic considerations in the hepatic artery and portal vein. Radiographics 2002, 22: 1077-1091. 10.1148/radiographics.22.5.g02se191077
Matsui O, Takashima T, Kadoya M, et al.: Dynamic computed tomography during arterial portography: the most sensitive examination for small hepatocellular carcinomas. J Comput Assist Tomogr 1985, 9: 19-24. 10.1097/00004728-198501000-00004
Matsui O, Kobayashi S, Sanada J, et al.: Hepatocelluar nodules in liver cirrhosis: hemodynamic evaluation (angiography-assisted CT) with special reference to multi-step hepatocarcinogenesis. Abdom Imaging 2011, 36: 264-272. 10.1007/s00261-011-9685-1
Minamiguchi H, Kawai N, Sato M, et al.: Hepatoma feeding arteriogram created by CT during aortography using IVR 64-multidetector-row CT for catheterization in transcatheter arterial chemoembolization for hepatocellular carcinoma. Jpn J Radiol 2013, 31: 428-436. 10.1007/s11604-013-0205-9
Remy-Jardin M, Bouaziz N, Dumont P, et al.: Bronchial and nonbronchial systemic arteries at multi-detector row CT angiography: comparison with conventional angiography. Radiology 2004, 233: 741-749. 10.1148/radiol.2333040031
Yonemitsu T, Kawai N, Sato M, et al.: Evaluation of transcatheter arterial embolization with gelatin sponge particles, microcoils, and n-butyl cyanoacrylate for acute arterial bleeding in a coagulopathic condition. J Vasc Interv Radiol 2009, 20: 1176-1187.
Ziyawudong J, Kawai N, Sato M, et al.: Aortic ostia of the bronchial arteries and tracheal bifurcation: MDCT analysis. World J Radiol 2012, 28(4):29-35.
The authors declare that they have no competing interests.
HM, NK and SH conceived of an idea to make a hemorrhage-responsible arteriogram. HM, NK, AI, HS and KN carried out the embolization for acute arterial hemorrhage. FT, MN and TS accumulated the image data. KM, SH and TN created the real hemorrhage-responsible arteriogram. HM and MS wrote and revised the manuscript. All authors read and approved the final manuscript.
Authors’ original submitted files for images
Below are the links to the authors’ original submitted files for images.
About this article
Cite this article
Minamiguchi, H., Kawai, N., Sato, M. et al. Volume-rendered hemorrhage-responsible arteriogram created by 64 multidetector-row CT during aortography: utility for catheterization in transcatheter arterial embolization for acute arterial bleeding. SpringerPlus 3, 67 (2014). https://doi.org/10.1186/2193-1801-3-67
- Volume-rendered hemorrhage-responsible arteriogram
- CT during aortography
- Acute arterial bleeding
- Transcatheter arterial embolization
- Multidetector-row CT