A handy approximation for a mediated bioelectrocatalysis process, related to Michaelis-Menten equation
- Uriel Filobello-Nino1,
- Hector Vazquez-Leal1Email author,
- Brahim Benhammouda3,
- Luis Hernandez-Martinez2,
- Yasir Khan4,
- Victor Manuel Jimenez-Fernandez1,
- Agustin Leobardo Herrera-May5,
- Roberto Castaneda-Sheissa1,
- Domitilo Pereyra-Diaz1,
- Juan Cervantes-Perez1,
- Jose Antonio Agustin Perez-Sesma1,
- Sergio Francisco Hernandez-Machuca1 and
- Leticia Cuellar-Hernandez1
© Filobello-Nino et al.; licensee Springer. 2014
Received: 19 December 2013
Accepted: 19 March 2014
Published: 27 March 2014
In this article, Perturbation Method (PM) is employed to obtain a handy approximate solution to the steady state nonlinear reaction diffusion equation containing a nonlinear term related to Michaelis-Menten of the enzymatic reaction. Comparing graphics between the approximate and exact solutions, it will be shown that the PM method is quite efficient.
KeywordsMichaelis-Menten kinetics Perturbation method Reaction/diffusion equation Mediated bioelectrocatalysis
Michaelis-Menten equation is used to describe the kinetics of enzyme-catalyzed reactions for the case in which the concentration of substrate is grater than the concentration of enzyme. These reactions are important in biochemistry because the most of cell processes require enzymes to obtain a significant rate (Michaelis and Menten 1913; Murray 2002). Enzymes are large protein molecules, which act as remarkably catalyst to speed up chemical reactions in living beings. With this end, they do work on specific molecules, called substrates; without the presence of enzymes, the majority of chemical reactions that keep living things alive would be too slow to maintain life (Michaelis and Menten 1913).
As it was already mentioned, the aim of this study is to find a handing approximate solution which best describes a reaction diffusion process related to Michaelis-Menten kinetics. Several oxidoreductase reactions such as quinones and ferrocenes consist of electrode reactions which allow conjugating between redox enzyme reactions and electrode reactions. The redox compound-mediated and enzyme catalysed electrode process is called mediated bioelectrocatalysis (Thiagarajan et al. 2011). Among its applications in engineering it is utilized for biosensors, bioreactors, and biofuel cells. Therefore, it is important the search for accurate solutions for this equation. Unfortunately, solving nonlinear differential equations is not a trivial process.
The Perturbation Method (PM) is a well established method; it is among the pioneer techniques to approach various types of nonlinear problems. This procedure was originated by S. D. Poisson and extended by J. H. Poincare. Although the method appeared in the early 19th century, the application of a perturbation procedure to solve nonlinear differential equations was performed later on that century. The most significant efforts were focused on celestial mechanics, fluid mechanics, and aerodynamics (Chow 1995; Filobello-Nino et al. 2013; Holmes 1995).
In general, it is assumed that the differential equation to be solved can be expressed as the sum of two parts, one linear and the other nonlinear. The nonlinear part is considered as a small perturbation represented by a small parameter (the perturbation parameter). The assumption that the nonlinear part is small compared to the linear is considered as a disadvantage of the method. There are other modern alternatives to find approximate solutions to differential equations describing some nonlinear problems such as those based on: variational approaches (Assas 2007; He 2007; Kazemnia et al. 2008; Noorzad et al. 2008), Tanh method (Evans and Raslan 2005), exp-function (Mahmoudi et al. 2008; Xu 2007), Adomian’s decomposition method (Adomain 1988; Babolian and Biazar 2002; Chowdhury 2011; Jiao et al. 2001; Kooch and Abadyan 20112012; Vanani et al. 2011), parameter expansion (Zhang and Xu 2007), homotopy perturbation method (Beléndez et al. 2009; Biazar and Aminikhan 2009; Biazar and Ghazvini 2009; El-Shaed 2005; Fathizadeh et al. 2011; Faraz and Khan 2011; Feng et al. 2007; Fereidoon et al. 2010; Filobello-Nino et al. 2012a2012b; Ganji et al. 20082009; He 19992000a2006a2006b2008; Hossein 2011; Khan et al. 20112013; Madani et al. 2011; Mirmoradia et al. 2009; Noor and Mohyud-Din 2009; Sharma and Methi 2011; Thiagarajan et al. 2011; Vazquez-Leal et al. 2012a2012b), and homotopy analysis method (Hassana and El-Tawil 2011; Patel et al. 2012), among many others.
Although the PM method provides, in general, better results for small perturbation parameters ε<<1; we will see that our approximation, besides of being handy, has good accuracy even for relatively large values of the perturbation parameter.
The paper is organized as follows. First, we introduce the basic idea of the PM method. Second, we provide an application of the PM method solving the bioelectrocatalysis process already mentioned. Next, we discuss significant results obtained by applying the method. Finally, a brief conclusion is given.
Basic idea of perturbation method
where we assume that x is a function of one variable x=x(t), L(x) is a linear operator which, in general, contains derivatives in terms of t, N(x) is a nonlinear operator, and ε is a small parameter.
Substituting (2) into (1) and equating terms having identical powers of ε, we obtain a number of differential equations that can be integrated, recursively, to determine the unknown functions: x0(t),x1(t),x2(t)…
Approximate solution for the nonlinear reaction/diffusion equation under study
where k and α denote positive reaction diffusion and saturation parameters, respectively, for the mentioned process; y is the mediator concentration and x the distance (Thiagarajan et al. 2011).
and f(x) is the right hand side of (13).
We consider, as a case study, the following values for parameters: α=0.1, α=1, and α=1.5 for k=0.1,1,5,10,20,50, and 100.
Nonlinear phenomena appear in such broad scientific fields like applied mathematics, physics, and engineering. Scientists in those disciplines face, constantly, with the task of finding solutions for nonlinear ordinary differential equations. As a matter of fact, the possibility of finding analytical solutions for those cases is very difficult and cumbersome.
The PM method provides in general, better results for small perturbation parameters ε<<1 (see (1)) and when are included the most number of terms from (2). To be precise, ε is a parameter of smallness; measures how much larger is the contribution of linear term L(x) than N(x) in (1). Although Figure 1 for α=0.1 satisfies that condition, Figure 2 and Figure 3 show that (20) provides a good approximation as solution to (3); despite of the fact that perturbation parameters α=1 and α=1.5, cannot be considered small. Since that the transport and kinetics are quantified in terms of k and α, it is important that our solutions have good accuracy for a wide range of values for both parameters.
In (Thiagarajan et al. 2011), HPM method was employed to provide an approximate solution to (3). Although the solution reported has good accuracy, it is too long for practical applications. Unlike the above, (20) provides good accuracy, it is simple, and computationally more efficient.
Finally, our approximate solution (20) does not depend on any adjustment parameter, for which, it is in principle, a general expression for the exposed problem.
An important task is to find an analytical expression that provides a good description of the solution for the nonlinear differential equations like (3). For instance, the time independent nonlinear reaction diffusion process, corresponding to a nonlinear Michaelis-Menten kinetic scheme is adequately described by (20). This work showed that some nonlinear problems can be adequately approximated employing the PM method, even for large values of the perturbation parameter; as it was done for the problem described by (3). The success of the method for this case has to be considered as an alternative to approach other nonlinear problems; this may lead to save time and resources employed using sophisticated and difficult methods. Figures 1 thru 3 show the accuracy of the proposed solutions.
We gratefully acknowledge the financial support from the National Council for Science and Technology of Mexico (CONACyT) through grant CB-2010-01 #157024. Also, authors would like to thank Rogelio-Alejandro Callejas-Molina and Roberto Ruiz-Gomez for their contribution to this project.
- Adomain G: A review of decomposition method in applied mathematics. J Math Anal Appl 1988, 135: 501-544. 10.1016/0022-247X(88)90170-9View ArticleGoogle Scholar
- Assas LMB: Approximate solutions for the generalized k-dv- burgers’ equation by he’s variational iteration method. Phys Scripta 2007, 76: 161-164. 10.1088/0031-8949/76/2/008View ArticleGoogle Scholar
- Babolian E, Biazar J: On the order of convergence of adomian method. Applied Mathematics and Computation 2002, 130: 383-387. 10.1016/S0096-3003(01)00103-5View ArticleGoogle Scholar
- Beléndez A, Pascual C, Álvarez ML, Méndez DI, Yebra MS, Hernández A: High order analytical approximate solutions to the nonlinear pendulum by he’s homotopy method. Physica Scripta 2009, 79: 1-27.View ArticleGoogle Scholar
- Biazar J, Aminikhan H: Study of convergence of homotopy perturbation method for systems of partial differential equations. Comput Math Appl 2009, 58: 2221-2230. 10.1016/j.camwa.2009.03.030View ArticleGoogle Scholar
- Biazar J, Ghazvini H: Convergence of the homotopy perturbation method for partial differential equations. Nonlinear Anal Real World Appl 2009, 10: 2633-2640. 10.1016/j.nonrwa.2008.07.002View ArticleGoogle Scholar
- Chow TL: Classical Mechanics. New York: John Wiley & Sons Inc; 1995.Google Scholar
- Chowdhury SH: A comparison between the modified homotopy perturbation method and adomian decomposition method for solving nonlinear heat transfer equations. J Appl Sci 2011, 11: 1416-1420.View ArticleGoogle Scholar
- El-Shaed M: Application of he’s homotopy perturbation method to volterra’s integro-differential equation. Int J Nonlinear Sci Numerical Simul 2005, 6: 151-162.Google Scholar
- Evans DJ, Raslan KR: The tanh function method for solving some important nonlinear partial differential equation. Int J Comput Math 2005, 82: 897-905. 10.1080/00207160412331336026View ArticleGoogle Scholar
- Fathizadeh M, Madani M, Khan Y, Faraz N, Yildirim A, Tutkun S: An effective modification of the homotopy perturbation method for mhd viscous flow over a stretching sheet. J King Saud Univ Sci 2011, 25: 107-113.View ArticleGoogle Scholar
- Faraz N, Khan Y: Analytical solution of electrically conducted rotating flow of a second grade fluid over a shrinking surface. Ain Shams Eng J 2011, 2: 221-226. 10.1016/j.asej.2011.10.001View ArticleGoogle Scholar
- Feng X, Mei L, He G: An efficient algorithm for solving troesch’s problem. Appl Math Comput 2007, 189: 500-507. 10.1016/j.amc.2006.11.161View ArticleGoogle Scholar
- Fereidoon A, Rostamiyan Y, Akbarzade M, Ganji DD: Application of he’s homotopy perturbation method to nonlinear shock damper dynamics. Arch Appl Mech 2010, 80: 641-649. 10.1007/s00419-009-0334-xView ArticleGoogle Scholar
- Filobello-Nino U, Vazquez-Leal H, Castaneda-Sheissa R, Yildirim A, Hernandez-Martinez L, Diaz DP, Perez-Sesma A, Hoyos-Reyes C: An approximate solution of blasius equation by using hpm method. Asian J Math Stat 2012a, 5: 50-59. 10.3923/ajms.2012.50.59View ArticleGoogle Scholar
- Filobello-Nino U, Vazquez-Leal H, Pereyra-Diaz D, Perez-Sesma A, Sanchez-Orea J, Castaneda-Sheissa R, Khan Y, Yildirim A, Hernandez-Martinez L, Rabago-Bernal F: Hpm applied to solve nonlinear circuits: A study case. Appl Math Sci 2012b, 6: 4331-4344.Google Scholar
- Filobello-Nino U, Vazquez-Leal H, Khan Y, Yildirim A, Jimenez-Fernandez VM, Herrera-May AL, Castaneda-Sheissa R, Cervantes-Perez J: Perturbation method and laplace–padé approximation to solve nonlinear problems. Miskolc Math Notes 2013, 14: 89-101.Google Scholar
- Ganji DD, Mirgolbabaei H, Miansari M, Miansari M: Application of homotopy perturbation method to solve linear and non-linear systems of ordinary differential equations and differential equation of order three. J Appl Sci 2008, 8: 1256-1261.View ArticleGoogle Scholar
- Ganji DD, Babazadeh H, Noori F, Pirouz MM, Janipour M: An application of homotopy perturbation method for non linear blasius equation to boundary layer flow over a flat plate. Int J Nonlinear Sci 2009, 7: 309-404.Google Scholar
- Hassana HN, El-Tawil MA: An efficient analytic approach for solving two point nonlinear boundary value problems by homotopy analysis method. Math Methods Appl Sci 2011, 34: 977-989. 10.1002/mma.1416View ArticleGoogle Scholar
- He JH: Homotopy perturbation technique. Comput Methods Appl Mech Eng 1999, 178: 257-262. 10.1016/S0045-7825(99)00018-3View ArticleGoogle Scholar
- He JH: A coupling method of a homotopy technique and a perturbation technique for nonlinear problems. Int J Non-Linear Mech 2000a, 35: 37-43. 10.1016/S0020-7462(98)00085-7View ArticleGoogle Scholar
- He JH: Homotopy perturbation method for solving boundary value problems. Physics Letters A 2006a, 350: 87-88. 10.1016/j.physleta.2005.10.005View ArticleGoogle Scholar
- He JH: Some asymptotic methods for strongly nonlinear equations. Int J Modern Phys B 2006b, 20: 1141-1199. 10.1142/S0217979206033796View ArticleGoogle Scholar
- He JH: Variational approach for nonlinear oscillators. Chaos, Solitons Fractals 2007, 34: 1430-1439. 10.1016/j.chaos.2006.10.026View ArticleGoogle Scholar
- He J H: Recent development of the homotopy perturbation method. Topological Methods Nonlinear Anal 2008, 31: 205-209.Google Scholar
- Holmes MH: Introduction to Perturbation Methods. New York: Springer; 1995.View ArticleGoogle Scholar
- Hossein A: Analytical approximation to the solution of nonlinear blasius viscous flow equation by ltnhpm. Int Sch Res Netw ISRN Math Anal 2011., 10: DOI:10.5402/2012/957473Google Scholar
- Jiao YC, Yamamoto Y, Dang C, Hao Y: An aftertreatment technique for improving the accuracy of adomian’s decomposition method. Comput Math Appl 2001, 43: 783-798.View ArticleGoogle Scholar
- Kazemnia M, Zahedi SA, Vaezi M, Tolou N: Assessment of modified variational iteration method in bvps high-order differential equations. J Appl Sci 2008, 8: 4192-4197. 10.3923/jas.2008.4192.4197View ArticleGoogle Scholar
- Khan Y, Wu Q, Faraz N, Yildirim A: The effects of variable viscosity and thermal conductivity on a thin film flow over a shrinking/stretching sheet. Comput Math Appl 2011, 61: 3391-3399. 10.1016/j.camwa.2011.04.053View ArticleGoogle Scholar
- Khan Y, Vazquez-Leal H, Wu Q: An efficient iterated method for mathematical biology model. Neural Comput Appl 2013, 23: 677-682. 10.1007/s00521-012-0952-zView ArticleGoogle Scholar
- Kooch A, Abadyan M: Evaluating the ability of modified adomian decomposition method to simulate the instability of freestanding carbon nanotube: comparison with conventional decomposition method. J Appl Sci 2011, 11: 3421-3428. 10.3923/jas.2011.3421.3428View ArticleGoogle Scholar
- Kooch A, Abadyan M: Efficiency of modified adomian decomposition for simulating the instability of nano-electromechanical switches: comparison with the conventional decomposition method. Trends Appl Sci Res 2012, 7: 57-67. 10.3923/tasr.2012.57.67View ArticleGoogle Scholar
- Madani M, Fathizadeh M, Khan Y, Yildirim A: On the coupling of the homotopy perturbation method and laplace transformation. Math Comput Model 2011, 53: 1937-1945. 10.1016/j.mcm.2011.01.023View ArticleGoogle Scholar
- Mahmoudi J, Tolou N, Khatami I, Barari A, Ganji DD: Explicit solution of nonlinear zk-bbm wave equation using exp-function method. J Appl Sci 2008, 8: 358-363. 10.3923/jas.2008.358.363View ArticleGoogle Scholar
- Michaelis L, Menten ML: Die kinetik der invertinwirkung. Biochem. Z 1913, 49: 333-369.Google Scholar
- Mirmoradia SH, Hosseinpoura I, Ghanbarpour S, Barari A: Application of an approximate analytical method to nonlinear troesch’s problem. Appl Math Sci 2009, 3: 1579-1585.Google Scholar
- Murray JD: Mathematical Biology: I. An Introduction. New York: Springer; 2002.Google Scholar
- Noor MA, Mohyud-Din ST: Homotopy approach for perturbation method for solving thomas-fermi equation using pade approximants. Int Nonlinear Sci 2009, 8: 27-31.Google Scholar
- Noorzad R, Tahmasebi-Poor A, Omidvar M: Variational iteration method and homotopy-perturbation method for solving burgers equation in fluid dynamics. J Appl Sci 2008, 8: 369-373. 10.3923/jas.2008.369.373View ArticleGoogle Scholar
- Patel T, Mehta MN, Pradhan VH: The numerical solution of burger’s equation arising into the irradiation of tumour tissue in biological diffusing system by homotopy analysis method. Asian J Appl Sci 2012, 5: 60-66. 10.3923/ajaps.2012.60.66View ArticleGoogle Scholar
- Sharma PR, Methi G: Applications of homotopy perturbation method to partial differential equations. Asian J Math Stat 2011, 4: 140-150.View ArticleGoogle Scholar
- Thiagarajan S, Meena A, Anitha S, Rajendran L: Analytical expression of the steady–state catalytic current of mediated bioelectrocatalysis and the application of he’s homotopy perturbation method. J Math Chem 2011, 49: 1727-17240. 10.1007/s10910-011-9854-zView ArticleGoogle Scholar
- Vanani SK, Heidari S, Avaji M: A low-cost numerical algorithm for the solution of nonlinear delay boundary integral equations. J Appl Sci 2011, 11: 3504-3509. 10.3923/jas.2011.3504.3509View ArticleGoogle Scholar
- Vazquez-Leal H, Filobello-Nino U, Castaneda-Sheissa R, Hernandez-Martinez L, Sarmiento-Reyes A: Modified hpm methods inspired by homotopy continuation methods. Math Probl Eng 2012a., 20: DOI: 10.1155/2012/309123Google Scholar
- Vazquez-Leal H, Castaneda-Sheissa R, Filobello-Nino U, Sarmiento-Reyes A, Sanchez-Orea J: High accurate simple approximation of normal distribution integral. Math Probl Eng 2012b., 22: DOI:10.1155/2012/124029Google Scholar
- Xu F: A generalized soliton solution of the konopelchenko-dubrovsky equation using exp-function method. Z Naturforsch 2007, 62a: 685-688.Google Scholar
- Zhang LN, Xu L: Determination of the limit cycle by he’s parameter expansion for oscillators in a u3/1+ u2 potential. Z Naturforsch 2007, 62a: 396-398.Google Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License(http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.