Bronchopleural fistula following M. abscessus infection 11 years after lobectomy for lung cancer
© Inayama et al.; licensee Springer. 2013
Received: 11 September 2013
Accepted: 22 October 2013
Published: 26 October 2013
Bronchopleural fistula (BPF) is a potentially fatal complication of lung cancer resection surgery that occurs during the healing process of the bronchial stump. However, the vulnerability of the healed surgical wound to overlapping acquired airway destruction has not yet been determined in detail. We herein present a case of fatal BPF following Mycobacterium abscessus (M. abscessus) infection, which occurred 11 years after right upper lobectomy for lung cancer. The findings of the present study suggest that patients with M. abscessus pulmonary disease in which airway destruction is progressing towards the bronchial stump of previous lobectomy should be considered for early completion pneumonectomy to prevent fatal BPF.
KeywordsRapidly growing nontuberculous mycobacteria Empyema Airway destruction
Bronchopleural fistula (BPF) is a rare, but potentially fatal complication of lung cancer resection surgery and has a high mortality rate (27.2 - 67 %). Management is very difficult once it has been diagnosed due to persistent empyema, refractory infection in the residual lungs, and subsequent sepsis (Lois and Noppen, 2005).
Mycobacterium abscessus (M. abscessus), a rapidly growing nontuberculous mycobacteria (NTM) that belongs to group IV of Runyon’s classification, has been well-known as a pathogen of skin and soft tissue infections following accidental trauma and surgery (Wallace et al., 1983; Chadha et al., 1998), and accounts for 80% of rapidly growing mycobacterial respiratory isolates. M. abscessus pulmonary diseases are rapidly progressive or multiresistant to antimicrobial drugs in many cases, and become intractable, which leads to severe airway destruction (Griffith et al., 2007).
We herein present a case of fatal BPF with empyema following M. abscessus infection, which occurred 11 years after right upper lobectomy for lung cancer.
Postoperative BPF can be classified into early and late BPF according to the time of occurrence: the former appears within a month of surgery, and the latter appears after more than one month (the average time of late BPF after lobectomy was reported to be 238.33 ± 164.12 days) (Jichen et al., 2009). Early BPF was shown to be related to perioperative technical problems, whereas late BPF was related to impaired healing of the bronchial stump (Varoli et al., 1998). Although several studies have identified some of the risk factors of postoperative early or late BPF, such as right pneumonectomy, infection, full-dose radiation, squamous carcinoma, and steroid use (Lois and Noppen, 2005; Jichen et al., 2009), few have focused on BPF following surgical wound healing.
On the other hand, non-postoperative BPF following necrotizing lung disease associated with chemotherapy or radiotherapy, persistent spontaneous pneumothorax, and lung necrosis complicating infection are less common (Lois and Noppen, 2005). Therefore, the vulnerability of the healed surgical wound to overlapping acquired airway destruction has not been fully determined. To the best of our knowledge, this is the first reported case of BPF after an extended period of time following lung cancer resection surgery, secondary to severe airway destruction caused by pulmonary NTM infection.
The frequency of NTM pulmonary disease is increasing, and is typically caused by slow-growing species such as M. avium-intracellulare complex (MAC) and M. kansasii in patients with or without preexisting lung disease (Griffith et al., 2007). However, as shown in our case, the microbial substitution of MAC to M. abscessus in NTM patients after long-term treatment with multiple drugs for previous MAC pulmonary disease has become a serious problem (Nei et al., 2007). In contrast with MAC infection, patients with M. abscessus infection require chemotherapy with parenteral antibiotics such as amikacin, cefoxitin, and imipenem for several weeks. However, this response is often temporary. M. abscessus pulmonary disease in our patient was also very difficult to eradicate and become refractory, leading to massive airway destruction (Figures 1, 2 and 3).
Surgical resection is commonly recommended for patients with localized M. abscessus pulmonary disease (Griffith et al., 2007). However, in many cases, lobectomy cannot fully remove bronchiectasis and damaged lung parenchyma due to an underlining pulmonary disease such as previous tuberculosis, MAC infection, and middle-lobe syndrome. In addition, the relatively high complication rate of pneumonectomy (Sherwood et al., 2005) was not suitable for the surgical treatment of our patient, who had a very low BMI, with a history of upper lobectomy. As a result, we missed the timing for surgery and BPF triggered the rapid progression of M. abscessus pulmonary disease, leading to respiratory failure.
The findings of our study suggest that patients with M. abscessus pulmonary disease in which airway destruction is progressing towards the bronchial stump of previous lobectomy should be considered for early completion pneumonectomy to prevent fatal BPF.
Written informed consent was obtained from the patient’s family for the publication of this report and any accompanying images.
- Chadha R, Grover M, Sharma A, Lakshmy A, Deb M, Kumar A, Mehta G: An outbreak of post-surgical wound infections due to Mycobacterium abscessus. Pediatr Surg Int 1998, 13: 406-410. 10.1007/s003830050350View ArticleGoogle Scholar
- Griffith DE, Aksamit T, Brown-Elliott BA, Catanzaro A, Daley C, Gordin F, Holland SM, Horsburgh R, Huitt G, Iademarco MF, Iseman M, Olivier K, Ruoss S, von Reyn CF, Wallace RJ Jr, Winthrop K: An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. Am J Respir Crit Care Med 2007, 175: 367-416. 10.1164/rccm.200604-571STView ArticleGoogle Scholar
- Jichen QV, Chen G, Jiang G, Ding J, Gao W, Chen C: Risk factor comparison and clinical analysis of early and late bronchopleural fistula after non-small cell lung cancer surgery. Ann Thorac Surg 2009, 88: 1589-1593. 10.1016/j.athoracsur.2009.06.024View ArticleGoogle Scholar
- Lois M, Noppen M: Bronchopleural fistulas: an overview of the problem with special focus on endoscopic management. Chest 2005, 128: 3955-3965. 10.1378/chest.128.6.3955View ArticleGoogle Scholar
- Nei T, Saitoh T, Morimoto K, Watanabe K, Hayashihara K, Azuma A, Kudoh S: Microbial substitution of Mycobacterium avium-intracellulare to Mycobacterium abscessus during clinical course. J Infect Chemother 2007, 13: 343-345. 10.1007/s10156-007-0545-4View ArticleGoogle Scholar
- Sherwood JT, Mitchell JD, Pomerantz M: Completion pneumonectomy for chronic mycobacterial disease. J Thorac Cardiovasc Surg 2005, 129: 1258-1265. 10.1016/j.jtcvs.2004.12.053View ArticleGoogle Scholar
- Varoli F, Roviaro G, Grignani F, Vergani C, Maciocco M, Rebuffat C: Endoscopic treatment of bronchopleural fistulas. Ann Thorac Surg 1998, 65: 807-809. 10.1016/S0003-4975(97)01427-6View ArticleGoogle Scholar
- Wallace RJ Jr, Swenson JM, Silcox VA, Good RC, Tschen JA, Stone MS: Spectrum of disease due to rapidly growing mycobacteria. Rev Infect Dis 1983, 5: 657-679. 10.1093/clinids/5.4.657View ArticleGoogle Scholar
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