Marker | General description/expression on normal stem cells | Expression on cancer stem cells | TF-carrying CSC marker (source) |
---|---|---|---|
CD34 | Transmembrane protein 105-120Â kDa Adhesion protein Immature hematopoietic stem/progenitor cells, endothelial progenitor cells2 | Leukemias, sarcomas2 | AML cell line KG-1 (1) |
CD44 | Hyaluronan receptor, H-CAM, epican, phagocytic glycoprotein-1 80-95Â kDa Adhesion protein, binds hyaluronic acid Hematopoietic and non-hematopoietic stem/progenitor cells2 | Cancer of colon, breast, ovary, lung, liver, stomach, etc.2 | Colon cancer cell line HT29 (2), lung, breast, and liver cancer (3) Carries also Lewis Y (4) |
CD45 | Leucocyte common antigen (LCA) 180-240Â kDa Hematopoietic stem cells (7) | Glioblastomas (5) | Acute T cell leukemia cell line Jurkat (6) |
CD164 | MGC-24, endolyn 80Â kDa Mucin-like glycoprotein Hematopoietic progenitor cells (10) | Gastric and prostate cancer (8, 9) | Gastric cancer cell line KATO-III (8) |
CD227 | Mucin-1, MUC1, EMA, PEM >200Â kDa Heavily glycosylated mucin MUC1-C interacts with regulatory pathways Hematopoietic progenitor cells (13) | Breast cancer (MCF7) side population (12), gastric cancer, AML (13), multiple myelomas (14) | Breast cancer (11); gastric cancer cell line KATO-III (8) |
MAGP1 | Membrane glycoproteins from human melanoma cell lines 140Â kDa (MAGP1), 110Â kDa (MAGP2) | Highly metastatic melanoma cell lines (15) | Highly metastatic cell lines (e.g. T1C3) derived from M4Be (15) |