- Open Access
A review on the role of quinones in renal disorders
© Madeo et al.; licensee Springer. 2013
- Received: 3 December 2012
- Accepted: 10 March 2013
- Published: 1 April 2013
Quinones are electron and proton carriers that play a primary role in the aerobic metabolism of virtually every cell in nature. Most physiological quinones are benzoquinones. They undergo highly regulated redox reactions in the mitochondria, Golgi apparatus, plasma membrane and endoplasmic reticulum. Important consequences of these electron transfer reactions are the production of and protection against reactive oxygen species (ROS). Quinones have been extensively studied for both their cytotoxic as well as cellular protective properties and they have been particularly useful in rational drug design. The role of quinones in medicine is explored in this literature review with a particular focus on renal diseases. Due to their high basal metabolism and detoxification role, the kidneys are particularly sensitive to oxidative stress. Regardless of the underlying etiology, ROS plays an important role in both acute kidney injury (AKI) and chronic kidney diseases (CKD). Depending on the oxidative state of the kidney, quinones can be nephrotoxoic or nephro-protective. Many factors play a role in the interaction between quinones and the kidney and the consequences of this are just beginning to be explored.
- Acute kidney injury (AKI)
- Chronic kidney disease
- Co-enzyme Q
- Proton carriers
- Reactive oxygen species (ROS)
Ubiquinones (co-enzymes Q) are found in the cells of all aerobic organisms from the simplest bacteria to humans. They mediate important proton and electron transfer reactions in the mitochondria, chloroplasts, Golgi apparatus, endoplasmic reticulum and the plasma membrane of oxidative bacteria. Thus they are of key importance in producing energy during oxidative metabolism and photosynthesis. The electrons are ultimately used to reduce molecular oxygen to water releasing the energy necessary to sustain the life of the cell. Disruption of this process can lead to disease states. NADH:ubiquinone oxidoreductase (Complex 1), the largest multi-meric enzyme complex of the mitochondrial respiratory chain, is a well-studied example involved in many disease states including cancer (Albracht et al.2011). Dysfunction of this complex is the most common oxidative phosphorylation disorder in humans (Mimaki et al.1817). Leigh syndrome, a subacute necrotizing encephalomyelopathy is a well-known example of this (Leigh1951). Redox reactions mediated by benzoquinones are the source of potentially cytotoxic reactive oxygen species (ROS) including superoxide, hydrogen peroxide, and the hydroxyl radical. Quinone mediated ROS can cause cellular damage through alkylation reactions with lipids, proteins, and DNA (Bolton et al.2000). Depending on the particular system, quinones can act as anti-oxidants and protect healthy cells against ROS, or act as cytotoxic agents, generating ROS in unhealthy cancer cells. The generation of ROS and its cytotoxic effects depend on the inducing chemical, the host tissue, and other factors that likely influence the electrochemical environment. This has been observed with the effects of nanomaterials on cells and tissues. A review of the literature revealed that an inflammatory response and an increased production of ROS are common immune responses to nanomaterial use which has implications for drug delivery systems (Syed et al.2012). On the other hand, thin walled carbon nanotubes do not appear to produce cellular damage despite the fact that they produce ROS (Thurnherr et al.2011; Ogasawara et al.2012).
Quinones are of interest from a medical and toxicological prespective due to their unique reactivity and high prevalence in the environment (Ralph et al.2011; Monks & Jones2002). They undergo highly regulated redox reactions while bound to specific sites in integral membrane proteins such as the cytochrome b6f (Kurisu et al.2003), QFR (QP,QD) (Iverson et al.2001), succinate dehydrogenase (Yankovskaya et al.2003), DsbB (Zhou et al.2008) cytochrome bc1 oxidoreductase (Gao et al.2003) and photosynthetic reaction centers (Stowell et al.1997). One extensively studied system that has significantly increased our understanding the role of quinone electrochemistry in biology is bacterial reaction centers (Gunner et al.2008). Reaction centers (RCs) are large membrane-bound proteins that use the energy of a photon to catalyze a series of electron transfer reactions during the process of photosynthesis. Ubiquinone-10 simultaneously binds to 2 unique active sites and the protein mediates electron transfer between them (Stowell et al.1997; Zhu & Gunner2005). This inevitably produces protein-bound free radicals that must be properly sequestered to avoid cytotoxic damage (Madeo & Gunner2005). Studying this system has provided much insight how proteins have evolved to shift the energy of electron transfer reactions to fit the needs of the cell (Madeo et al.2011).
Quinones play an important role in medicine. Oxidative stress occurs when there is an imbalance between the production and quenching of free radicals from oxygen species. The mitochondria play a central role in the formation of excess ROS. Quinones can target the mitochondria and re-establish electron transfer in deficiency states. For example, in antiphospholipid syndrome, treatment with co-enzyme Q has been shown been shown to alter mitochondrial dynamics resulting in lower oxidative stress and slowing of the accelerated atherosclerosis (Perez-Sanchez et al.2012). Co-enzyme Q has also been shown to prevent retinal cell apoptosis when given as eye drops in mouse models of kainate-induced retinal damage (Lulli et al.2012). Quinones are also being investigated for the treatment of mitochondrial diseases (Enns et al.2012) as well as age-related diseases (Skulachev et al.2009). In one small open-label study, patients with terminal genetic mitochondrial diseases were treated with a para-benzoquinone (alpha-trocotrienol quinone) for 13 weeks as an emergency treatment protocol. This therapy modified disease progression in 90% of the patients by increasing quality of life and improving central nervous system oxidation state (Enns et al.2012). This quinone is currently undergoing clinical trials for diseases such as Friedreich’s ataxia, Leigh Syndrome, and Tourette syndrome.
Depending on their redox state, quinones can act as both pro and anti-oxidants and their action in the mitochondrial is highly dependent on their concentration. Ubiquinone-10, a fat soluble quinone, is found in particularly high concentrations in the mitochondria of cells in the brain, heart, liver, and kidney. Deficiencies in ubiquinone-10 have been associated with the pathology of a diverse number of diseases, including encephalopathy, myopathy, male infertility, and nephrotic syndrome (Villalba et al.2010; Quinzii & Hirano2010; Balercia et al.2009). Accelerated arteriosclerosis is driven by the proinflammatory response and ubiquinones in the plasma appear to play a protective role against coronary artery disease. Co-enzyme Q, by interfering with the production of ROS, protects circulating lipoproteins including LDL from oxidation thereby slowing the progress of coronary artery disease (Morre & Morre2011; Tsai et al.2011). During arteriosclerosis, oxidized LDL binds to an endothelial cell receptor triggering a signal transduction pathway that activates NADPH oxidase resulting in the generation of ROS. The oxidative insult to the endothelium plays a key role in the pathogenesis of arteriosclerosis. This pathway was interrupted in endothelial cells pretreated with co-enzyme Q diminishing endothelial oxidative damage (Tsai et al.2011). Any systemic inflammatory disease has the potential to cause oxidative damage due to the increase in aerobic metabolism and thus could benefit from these protective effects. An important example is in systemic lupus erythematosus where accelerated atherosclerosis plays an important role (Kurien & Scofield2008; Frieri2012).
NAD(P)H:quinone oxidoreductase 1 (NQO1) is an enzyme important in maintaining oxygen homeostasis. It is a flavoprotein that catalyzes the reduction of quinones, vitamin E, and nitrogen oxides. These reduction reactions generate natural antioxidants (such as reduced form of vitamin E and ubiquinol) and are important for both intrinsic and exogenous chemical detoxification (Ross et al.2000). Such reactions can protect against exogenous quinones that would otherwise promote the generation of ROS. On the other hand, depending on the specific initial quinone, these reduction reactions can generate labile products that react with molecular oxygen to generate ROS and cause DNA and protein alkylation that can thus destroy the cell. This is the principle behind NQO1 anti-tumor drugs. Compounds of the quinone family such as mitomycin C are efficiently bioactivated by NQO1, a cytosolic two-electron reductase. This enzyme activates anti-tumor pro-drugs and is thus a necessary agent for their anti-tumor activity (Begleiter et al.1997). Due to the fact that NQO1 is expressed in particularly high levels in tumor cells, these drugs target cancerous cells before becoming toxic to normal cells. Drugs that target succinate: quinone reductase/Complex II, another enzyme found in particularly high levels in tumor cells, is also being developed based on this principle (Ralph et al.2006).
Dysregulated ROS production can be cytotoxic, particularly to cancer cells that have a high metabolism. Cancer cells are particularly sensitive to insults in redox homeostasis. ROS production can activate genes involved in detoxification and regulated cell death (Dhakshinamoorthy et al.2000). Many cancer cells maintain a moderate level of oxidative stress and current investigations are aiming at exploiting this for targeted cell death (McCarty et al.2010). Quinones, due to their redox cycling ability, are being used to exploit this process and thus represent a large class of antitumor drugs currently under investigation (Siegel et al.2012; Sagar et al.2010). These drugs particularly target cancer cells rather than healthy cells. The mechanism of death appears to involve ATP depletion, calcium imbalance, and protein degradation (Verrax et al.2011). The reduction of quinones by NQO1 plays an important role. There is still a lot of research that needs to be done to understand the role anti-oxidants play in signal transduction and altering gene expression. The better we can understand these mechanisms the better we can design specific drugs that target specific cancers. For example, NQO1 triggers a NF-ĸB mediated signal transduction pathway that regulates apoptosis; NF-ĸB is an important transcription factor in the pathogenesis of many cancers, including breast cancer (Zubair & Frieri2012). One study showed that expression of NQO1 and NF-ĸB were inversely related in breast tissue implicating a unique pathway that can be targeted for rational drug design (Jamshidi et al.2012).
Due to their anti-oxidant effects, quinones are also currently being investigated as part of the treatment of head trauma (Kalayci et al.2011) and neurological diseases like Parkinson disease (Kerr2010; Rakoczi et al.2009), Huntington disease, (Hyson et al.2010) and Alzheimer disease (Yang et al.2010). On the other hand quinones are involved in the induction of cancer and neurodegenerative disease (Zahid et al.2010; Cavalieri & Rogan2006). Quinone derivatives of estrogens, benzene, and dopamine have been showed to promote formation of DNA adducts that initiate mutations leading to cancer as well as neurodegenerative diseases (Zahid et al.2010). Plastoquinol, an anti-oxidant found in chloroplasts, is being investigated for its involvement in the suppression of age-related pathologies such as declining immunity, balding, cataracts and osteoporosis (Skulachev et al.2011). Aging is associated oxidative stress, thus quinones have a potential role in modulating the process (Soares et al.2011). Lastly, quinones are still being investigated for their antimalarial effect (Qu et al.2010; Jacquerioz & Croft2009).
Hypoxia and cellular reactions to oxidative stress are at the heart of the complex pathogenesis of both acute and chronic kidney diseases (Nangaku2006; Aksu et al.2011). Acute kidney injury (AKI) affects millions of people and has been associated with increased mortality and hospital length of stay as well as puts the patient at risk for future chronic kidney disease (CKD) (Singbartl & Kellum2012). Regardless of the etiology, the pathology of AKI is intimately tied to renal microcirculation and mitochondrial dysfunction resulting in disruption of oxygen homeostasis, uncontrolled inflammation, and production of ROS (Kunzendorf et al.2010). ROS can promote cell death by both necrosis and apoptosis. ROS production is triggered by ischemic/reperfusion injury (Eltzschig & Eckle2011), antibiotics such as aminoglycosides (Ali et al.2011), contrast induced renal injury (Oudemans-van Straaten2005), rhabdomyolysis (Boutaud & Roberts2011) and toxic materials (Gobe & Crane2010; Chen et al.2011). Therapeutic interventions aimed at inhibiting these pathological redox reactions is an active area of current research. NAD(P)H:quinone oxidoreductase is a redox enzyme found in particularly high levels in renal tubular cells and likely contributes to pathogenesis of renal failure. Renal specific oxidases are known to be involved in ROS medicated damage in kidney mesangial cells (Orient et al.2007). Natural anti-oxidant agents have shown some promise in ameliorating aminoglycoside toxicity (Ali et al.2011; Sayed-Ahmed & Nagi2007) and cisplatin-induced nephropathy (Mukhopadhyay et al.2012). The role of antioxidants in the management of AKI is an ongoing area of research (Koyner et al.2008).
Oxidative stress is known to play an important role in the development of renal diseases such as glomerulonephritis, drug-induced nephrotoxicity, and CKD (Okamura & Himmelfarb2009). CKD is associated with mitochondrial dysfunction that leads to an imbalance between ROS and the natural anti-oxidants that normally quench these pathological free radicals. In particular hypertensive nephropathy and proteinuria have been directly linked to salt-induced oxidative stress (Nagase et al.2007; Varagic et al.2010). One study showed that high salt intake activates the renin-angiotensin system, urinary protein excretion and nitroxidative markers in rat models (Varagic et al.2010). By using a novel beta-blocker with anti-oxidant function, this study showed that the kidney damage associated with the oxidative stress is independent of the hemodynamic damage of hypertension induced by the high salt diet. Salt loading increases activity of plasma membrane NADPH oxidase in the renal parenchyma, an enzyme important for production of ROS (Kitiyakara et al.2003). Oxidation of LDL by mesangial cells is important in the pathogenesis of lipoprotein glomerulopathy which can lead to rapid progressive renal failure (Sakatsume et al.2001). ROS production also appears to play a key role in diabetic nephropathy and could be induced by long-standing hyperglycemia (Forbes et al.2008). Angiotensin II facilitates ROS production in kidney mesangial cells which helps to explain the renoprotective role of ACE-inhibitors and angiotensin receptor blockers in these disorders (Gorin et al.2004). Another interesting role of anti-oxidants in renal disease is aristolochic acid 1 (AA1) nephropathy. This disease is associated with tubulointerstitial fibrosis and urothelial carcinoma following ingestion of AA1 (De Broe2012). Renal reduction, which is important for AA1 clearance, generates a toxic metabolite. One study showed that pre-treatment of mouse tubular epithelium with a NQO1 inhibitor increased the oxidized metabolite of AA1 in renal tissue leading to attenuation of AA1 induced nephropathy (Chen et al.2011). This highlights the importance of this enzyme in regulating renal oxidation and homeostasis and illustrates how genetic polymorphisms can contribute to a person’s susceptibility to this disease.
Quinones can be toxic or protective to the kidneys. The difference depends on the products produced by reduction and the oxidative state of the kidney. Stable fully oxidized quinones are less reactive and their production can quench other cellular toxins such as ROS. On the other hand, partially reduced semiquinones are free radicals that can damage DNA and lead to cell death (see Figure 1). Thymoquinone (TQ), a compound derived from Nigella sativa, shows strong anti-oxidant properties against gentamicin (GM)-induced nephrotoxicity. In a study using a rat model with GM-induced nephrotoxicity, TQ supplementation lowered BUN, creatinine and total nitrate/nitrite. It also increased glutathione peroxidase activity and ATP to match control values. TQ supplementation also prevented GM-induced renal histopathology. Based on these findings, the mechanism of TQ prevention is likely related to its ability to decrease oxidative stress by preserving the activity of the anti-oxidant enzymes (Sayed-Ahmed & Nagi2007). With evidence for a similar anti-oxidant mechanism, TQ also protects the kidney from vancomycin and cisplatin (Ragheb et al.2009; Basarslan et al.2012). Due to its anti-inflammatory, anti-allergic, and anti-carcinogenic effects, TQ has been used in traditional medicine for a diversity of diseases such as cancer, diabetes, and asthma (Khan et al.2011; Sankaranarayanan & Pari2011). One study observed that TQ reduced sepsis related morbidity and mortality in mice challenged with endotoxin Gram-negative bacteria. TQ reduced mortality by 80-90%, improved both kidney and liver function and it also lowered inflammatory biomarkers (Alkharfy et al.2011).
Hemodialysis (HD) and peritoneal dialysis (PD) are associated with increased oxidative stress which may be related to low levels of co-enzyme Q in the blood. The major risk of this oxidative stress is accelerated cardiovascular disease, the leading cause of death in dialysis patients. One observational study, comparing dialysis patients to healthy controls, found an association between lower co-enzyme blood levels and higher oxidative stress in dialysis patients (Mehmetoglu et al.2012). This has not been a consistent finding and larger, higher powered studies are needed before this relationship can be accepted (Gokbel et al.2011; Lippa et al.1994). Another small study followed 36 HD patients for 6 months and showed that co-enzyme Q10 administration was partially effective for suppressing the oxidative stress in HD patients (Sakata et al.2008). A recent Cohrane review examined the benefits and harms of giving antioxidants to CKD, dialysis, and kidney transplant patients (Jun et al.2012). Although the analysis did not detect a significant decrease in cardiovascular and all-cause death, there was evidence that antioxidant therapy significantly reduced development of end-stage of kidney disease in CKD patients and lowered serum creatinine levels. Significant adverse effects were not observed. The findings of these observational studies have led to the currently ongoing clinical trial assessing the effect of co-enzyme Q-10 on oxidative stress and systemic inflammation in HD patients and have encouraged larger, appropriately powered studies. Another renal protective role for quinones has been observed with cold-storage injury, which occurs with deceased donor kidneys that are stored at cold temperatures prior to transplantation. Oxidative damage, from mitochondrial superoxide generation, plays a role in the tissue injury that occurs during storage and re-warming (Mitchell et al.2010). Mitoquinone is a ubiquinone analog with a conjugated hydrophobic anion that targets the mitochondria and has been shown to protect against cold storage damage of renal tubular cells by preventing mitochondrial dysfunction (Mitchell et al.2011).
The toxicity of quinones to the kidney appears to depend on a variety of factors including genetic polymorphisms and the disease state of the individual. NQO1 is found, in particular high levels in podocytes indicating that these cells play a pivotal role in the oxidative state of the kidney (Tamura et al.2012; Marshall et al.2006). The likely role is a detoxifying enzyme, protecting the kidney from chemically reactive metabolites filtered through the glomerulus. Mitomycin C is an anticancer agent that is particularly toxic to the kidney and known to cause hemolytic uremic syndrome (Zappa et al.2003). It is a quinone that requires cellular reduction to activate its cytotoxic effects. Due to its ability to reduce quinones, NQO1 in podocytes could play a major role in the pathogenesis of renal toxicity and mitomycin C-induced hemolytic uremic syndrome. Injury to the glomerular filtration mechanism is the primary damage, leading to a cascade of deleterious events including microangiopathic hemolytic anemia and thrombocytopenia (Zappa et al.2003). The high expression of NQO1 explains, in theory, a selective toxicity towards podocytes. Another mechanism may be the formation of covalent protein quinol-thioether adducts. Glutathione (GSH) conjugates of hydroquinone (HQ) and 2-bromohydroquinone (2-BrHQ) produce severe renal proximal tubular necrosis in rats (Kleiner et al.1998).
Podocytes are the major cell of the glomerular filter. They are highly differentiated and quiescent cells involved in the pathology of numerous kidney diseases (Durvasula & Shankland2006; Garg & Holzman2012). The glomerular filtrate must traverse capillary endothelium, basement membrane, and the podocyte layer before reaching Bowman’s space. Podocytes also produce vascular endothelial growth factor (VEGF), which regulates glomerular endothelial permeability, thus playing an important role in the kidney interactions with potential toxins (Kretzler et al.1998). Expression of VEGF has been shown to be important in many renal diseases, particularly lupus nephritis (Frieri et al.2012). An acquired primary dysregulation of podocytes is described in collapsing idiopathic focal segmental glomerulosclerosis and in HIV-associated nephropathy (Barisoni et al.1999), another disease driven by unregulated oxidative stress.
Primary coenzyme Q10 deficiency is considered to be the only treatable mitochondrial disorder, since some patients have a response to oral coenzyme Q-10 (Salviati et al.2005). The disease usually manifests with nephropathy and encephalomyopathy (Montini et al.2008). It is caused by mutations in the enzymes of the coenzyme Q10 synthetic pathway. It has been linked with focal segmental glomerulosclerosis due to dysfunctional mitochondria in the podocytes. One study using a translational mouse model showed that giving probucol (a lipid soluble anti-oxidant) prevented an otherwise lethal glomerulopathy (Falk et al.2011). This drug resulted in higher levels of co-enzyme Q in kidney and liver compared to supplementation alone. The benefit appears to be due to effects on signaling pathways that alter gene expression resulting in reduction of oxidative stress. Since not all patients with co-enzyme Q deficiency respond to supplementation, alternative therapies targeting the signaling pathways that mediate oxidative stress are needed.
Another study described the effects of long-term coenzyme Q10 supplementation in a patient with coenzyme Q10 deficiency (Diomedi-Camassei et al.2007). Progressive recovery of renal function and resolution of nephritic syndrome were observed during the 50 months of treatment. Corticosteroids and immunosuppressive drugs were not needed. On the other hand, a second patient was treated with co-enzyme Q after the development of CKD and no change in renal function was observed. Thus, early administration of coenzyme Q10 appears to be important for the resolution of renal symptoms.
This literature review highlights the relationship between benzoquinones, oxidative stress, and renal disease. Quinones are small electron transfer molecules, found in virtually all cells that undergo aerobic metabolism, that play an important role in oxidative stress. Quinones have a diverse role in medicine, including anti-cancer agents and anti-aging and arteriosclerosis. Quinones can be renal toxic or renal protective. Thymoquinone protects the kidney from toxic effects of drugs, including gentamicin, vancomycin and cisplantin. Mitoquinone can protect against cold storage damage of deceased donor kidneys. Mitomycin C is an anticancer agent that is particularly toxic to renal podocytes because it targets the detoxifying enzyme NQO1. Primary coenzyme Q10 deficiency also results in kidney damage primarily due to dysfunctional mitochondria in the podocytes. CoQ10 administration was partially effective for suppressing the oxidative stress in dialysis patients. Although the role of co-enzyme Q in CKD and ESRD is not fully established, encouraging observational studies and lack of significant adverse effects encourage future investigations. Many factors play a role in the interaction between quinones, oxidative stress and kidney physiology. Future studies, including clinical trials, can help to better unravel this role and improve the management of patients with or at risk for kidney diseases.
The authors have no acknowledgments to disclose.
- Aksu U, Demirci C, Ince C: The pathogenesis of acute kidney injury and the toxic triangle of oxygen, reactive oxygen species and nitric oxide. Contrib Nephrol 2011, 174: 119-128.View ArticleGoogle Scholar
- Albracht SP, Meijer AJ, Rydstrom J: Mammalian NADH:ubiquinone oxidoreductase (Complex I) and nicotinamide nucleotide transhydrogenase (Nnt) together regulate the mitochondrial production of H(2)O(2)–implications for their role in disease, especially cancer. J Bioenerg Biomembr 2011, 43: 541-564. 10.1007/s10863-011-9381-4View ArticleGoogle Scholar
- Ali BH, Al Za'abi M, Blunden G: Experimental gentamicin nephrotoxicity and agents that modify it: a mini-review of recent research. Basic Clin Pharmacol Toxicol 2011, 109: 225-232. 10.1111/j.1742-7843.2011.00728.xView ArticleGoogle Scholar
- Alkharfy KM, Al-Daghri NM, Al-Attas OS: The protective effect of thymoquinone against sepsis syndrome morbidity and mortality in mice. Int Immunopharmacol 2011, 11: 250-254. 10.1016/j.intimp.2010.11.032View ArticleGoogle Scholar
- Balercia G, Mancini A, Paggi F: Coenzyme Q10 and male infertility. J Endocrinol Invest 2009, 32: 626-632.View ArticleGoogle Scholar
- Barisoni L, Kriz W, Mundel P: The dysregulated podocyte phenotype: a novel concept in the pathogenesis of collapsing idiopathic focal segmental glomerulosclerosis and HIV-associated nephropathy. J Am Soc Nephrol 1999, 10: 51-61.Google Scholar
- Basarslan F, Yilmaz N, Ates S: Protective effects of thymoquinone on vancomycin-induced nephrotoxicity in rats. Hum Exp Toxicol 2012, 31: 726-733. 10.1177/0960327111433185View ArticleGoogle Scholar
- Begleiter A, Leith MK, Curphey TJ: Induction of DT-diaphorase in cancer chemoprevention and chemotherapy. Oncol Res 1997, 9: 371-382.Google Scholar
- Bolton JL, Trush MA, Penning TM: Role of quinones in toxicology. Chem Res Toxicol 2000, 13: 135-160. 10.1021/tx9902082View ArticleGoogle Scholar
- Boutaud O, Roberts LJ 2nd: Mechanism-based therapeutic approaches to rhabdomyolysis-induced renal failure. Free Radic Biol Med 2011, 51: 1062-1067. 10.1016/j.freeradbiomed.2010.10.704View ArticleGoogle Scholar
- Cavalieri E, Rogan E: Catechol quinones of estrogens in the initiation of breast, prostate, and other human cancers: keynote lecture. Ann N Y Acad Sci 2006, 1089: 286-301. 10.1196/annals.1386.042View ArticleGoogle Scholar
- Chen M, Gong L, Qi X: Inhibition of renal NQO1 activity by dicoumarol suppresses nitroreduction of aristolochic acid I and attenuates its nephrotoxicity. Toxicol Sci 2011, 122: 288-296. 10.1093/toxsci/kfr138View ArticleGoogle Scholar
- De Broe ME: Chinese herbs nephropathy and Balkan endemic nephropathy: toward a single entity, aristolochic acid nephropathy. Kidney Int 2012, 81: 513-515. 10.1038/ki.2011.428View ArticleGoogle Scholar
- Dhakshinamoorthy S, Long DJ 2nd, Jaiswal AK: Antioxidant regulation of genes encoding enzymes that detoxify xenobiotics and carcinogens. Curr Top Cell Regul 2000, 36: 201-216.View ArticleGoogle Scholar
- Diomedi-Camassei F, Di Giandomenico S, Santorelli FM: COQ2 nephropathy: a newly described inherited mitochondriopathy with primary renal involvement. J Am Soc Nephrol 2007, 18: 2773-2780. 10.1681/ASN.2006080833View ArticleGoogle Scholar
- Durvasula RV, Shankland SJ: The renin-angiotensin system in glomerular podocytes: mediator of glomerulosclerosis and link to hypertensive nephropathy. Curr Hypertens Rep 2006, 8: 132-138. 10.1007/s11906-006-0009-8View ArticleGoogle Scholar
- Eltzschig HK, Eckle T: Ischemia and reperfusion–from mechanism to translation. Nat Med 2011, 17: 1391-1401. 10.1038/nm.2507View ArticleGoogle Scholar
- Enns GM, Kinsman SL, Perlman SL: Initial experience in the treatment of inherited mitochondrial disease with EPI-743. Mol Genet Metab 2012, 105: 91-102. 10.1016/j.ymgme.2011.10.009View ArticleGoogle Scholar
- Falk MJ, Polyak E, Zhang Z: Probucol ameliorates renal and metabolic sequelae of primary CoQ deficiency in Pdss2 mutant mice. EMBO Mol Med 2011, 3: 410-427. 10.1002/emmm.201100149View ArticleGoogle Scholar
- Forbes JM, Coughlan MT, Cooper ME: Oxidative stress as a major culprit in kidney disease in diabetes. Diabetes 2008, 57: 1446-1454. 10.2337/db08-0057View ArticleGoogle Scholar
- Frieri M: Accelerated atherosclerosis in systemic lupus erythematosus: role of proinflammatory cytokines and therapeutic approaches. Curr Allergy Asthma Rep 2012, 12: 25-32. 10.1007/s11882-011-0236-1View ArticleGoogle Scholar
- Frieri M, Samih MA, Dzhindzhikhashvili M: Toll-like receptor 9 and vascular endothelial growth factor levels in human kidneys from lupus nephritis patients. Curr Allergy Asthma Rep 2012, 25: 1041-1046.Google Scholar
- Gao X, Wen X, Esser L: Structural basis for the quinone reduction in the bc1 complex: a comparative analysis of crystal structures of mitochondrial cytochrome bc1 with bound substrate and inhibitors at the Qi site. Biochemistry 2003, 42: 9067-9080. 10.1021/bi0341814View ArticleGoogle Scholar
- Garg P, Holzman LB: Podocytes: gaining a foothold. Exp Cell Res 2012, 318: 955-963. 10.1016/j.yexcr.2012.02.030View ArticleGoogle Scholar
- Gobe G, Crane D: Mitochondria, reactive oxygen species and cadmium toxicity in the kidney. Toxicol Lett 2010, 198: 49-55. 10.1016/j.toxlet.2010.04.013View ArticleGoogle Scholar
- Gokbel H, Atalay H, Okudan N: Coenzyme Q10 and its relation with oxidant and antioxidant system markers in patients with end-stage renal disease. Ren Fail 2011, 33: 677-681. 10.3109/0886022X.2011.589941View ArticleGoogle Scholar
- Gorin Y, Ricono JM, Wagner B: Angiotensin II-induced ERK1/ERK2 activation and protein synthesis are redox-dependent in glomerular mesangial cells. Biochem J 2004, 381: 231-239. 10.1042/BJ20031614View ArticleGoogle Scholar
- Gunner MR, Madeo J, Zhu Z: Modification of quinone electrochemistry by the proteins in the biological electron transfer chains: examples from photosynthetic reaction centers. J Bioenerg Biomembr 2008, 40: 509-519. 10.1007/s10863-008-9179-1View ArticleGoogle Scholar
- Hyson HC, Kieburtz K, Shoulson I: Safety and tolerability of high-dosage coenzyme Q10 in Huntington's disease and healthy subjects. Mov Disord 2010, 25: 1924-1928.View ArticleGoogle Scholar
- Iverson TM, Arciero DM, Hooper AB: High-resolution structures of the oxidized and reduced states of cytochrome c554 from Nitrosomonas europaea. J Biol Inorg Chem 2001, 6: 390-397. 10.1007/s007750100213View ArticleGoogle Scholar
- Jacquerioz FA, Croft AM: Drugs for preventing malaria in travellers. Cochrane Database Syst Rev 2009, 4: CD006491.Google Scholar
- Jamshidi M, Bartkova J, Greco D: NQO1 expression correlates inversely with NFkappaB activation in human breast cancer. Breast Cancer Res Treat 2012, 132: 955-968. 10.1007/s10549-011-1629-5View ArticleGoogle Scholar
- Jun M, Venkataraman V, Razavian M: Antioxidants for chronic kidney disease. Cochrane Database Syst Rev 2012., 10: CD008176Google Scholar
- Kalayci M, Unal MM, Gul S: Effect of coenzyme Q10 on ischemia and neuronal damage in an experimental traumatic brain-injury model in rats. BMC Neurosci 2011, 12: 75. 10.1186/1471-2202-12-75View ArticleGoogle Scholar
- Kerr DS: Treatment of mitochondrial electron transport chain disorders: a review of clinical trials over the past decade. Mol Genet Metab 2010, 99: 246-255. 10.1016/j.ymgme.2009.11.005View ArticleGoogle Scholar
- Khan MA, Chen HC, Tania M: Anticancer activities of Nigella sativa (black cumin). Afr J Tradit Complement Altern Med 2011, 8: 226-232.Google Scholar
- Kitiyakara C, Chabrashvili T, Chen Y: Salt intake, oxidative stress, and renal expression of NADPH oxidase and superoxide dismutase. J Am Soc Nephrol 2003, 14: 2775-2782. 10.1097/01.ASN.0000092145.90389.65View ArticleGoogle Scholar
- Kleiner HE, Rivera MI, Pumford NR: Immunochemical detection of quinol–thioether-derived protein adducts. Chem Res Toxicol 1998, 11: 1283-1290. 10.1021/tx980134eView ArticleGoogle Scholar
- Koyner JL, Sher Ali R, Murray PT: Antioxidants. Do they have a place in the prevention or therapy of acute kidney injury? Nephron Exp Nephrol 2008, 109: e109-e117. 10.1159/000142935View ArticleGoogle Scholar
- Kretzler M, Schroppel B, Merkle M: Detection of multiple vascular endothelial growth factor splice isoforms in single glomerular podocytes. Kidney Int Suppl 1998, 67: S159-S161.View ArticleGoogle Scholar
- Kunzendorf U, Haase M, Rolver L: Novel aspects of pharmacological therapies for acute renal failure. Drugs 2010, 70: 1099-1114. 10.2165/11535890-000000000-00000View ArticleGoogle Scholar
- Kurien BT, Scofield RH: Autoimmunity and oxidatively modified autoantigens. Autoimmun Rev 2008, 7: 567-573. 10.1016/j.autrev.2008.04.019View ArticleGoogle Scholar
- Kurisu G, Zhang H, Smith JL: Structure of the cytochrome b6f complex of oxygenic photosynthesis: tuning the cavity. Science 2003, 302: 1009-1014. 10.1126/science.1090165View ArticleGoogle Scholar
- Leigh D: Subacute necrotizing encephalomyelopathy in an infant. J Neurol Neurosurg Psychiatry 1951, 14: 216-221. 10.1136/jnnp.14.3.216View ArticleGoogle Scholar
- Lippa S, Colacicco L, Calla C: Coenzyme Q10 levels, plasma lipids and peroxidation extent in renal failure and in hemodialytic patients. Mol Aspects Med 1994, 15(Suppl):s213-s219.View ArticleGoogle Scholar
- Lulli M, Witort E, Papucci L: Coenzyme Q10 instilled as eye drops on the cornea reaches the retina and protects retinal layers from apoptosis in a mouse model of kainate-induced retinal damage. Invest Ophthalmol Vis Sci 2012, 53: 8295-8302. 10.1167/iovs.12-10374View ArticleGoogle Scholar
- Madeo J, Gunner MR: Modeling binding kinetics at the Q(A) site in bacterial reaction centers. Biochemistry 2005, 44: 10994-11004. 10.1021/bi050544jView ArticleGoogle Scholar
- Madeo J, Mihajlovic M, Lazaridis T: Slow dissociation of a charged ligand: analysis of the primary quinone Q(A) site of photosynthetic bacterial reaction centers. J Am Chem Soc 2011, 133: 17375-17385. 10.1021/ja205811fView ArticleGoogle Scholar
- Marshall CB, Pippin JW, Krofft RD: Puromycin aminonucleoside induces oxidant-dependent DNA damage in podocytes in vitro and in vivo. Kidney Int 2006, 70: 1962-1973.View ArticleGoogle Scholar
- McCarty MF, Barroso-Aranda J, Contreras F: Oxidative stress therapy for solid tumors - a proposal. Med Hypotheses 2010, 74: 1052-1054. 10.1016/j.mehy.2009.12.029View ArticleGoogle Scholar
- Mehmetoglu I, Yerlikaya FH, Kurban S: Oxidative stress markers in hemodialysis and peritoneal dialysis patients, including coenzyme Q10 and ischemia-modified albumin. Int J Artif Organs 2012, 35: 226-232. 10.5301/ijao.5000078View ArticleGoogle Scholar
- Mimaki M, Wang X, McKenzie M: Understanding mitochondrial complex I assembly in health and disease. Biochim Biophys Acta 1817, 2012: 851-862.Google Scholar
- Mitchell T, Saba H, Laakman J: Role of mitochondrial-derived oxidants in renal tubular cell cold-storage injury. Free Radic Biol Med 2010, 49: 1273-1282. 10.1016/j.freeradbiomed.2010.07.012View ArticleGoogle Scholar
- Mitchell T, Rotaru D, Saba H: The mitochondria-targeted antioxidant mitoquinone protects against cold storage injury of renal tubular cells and rat kidneys. J Pharmacol Exp Ther 2011, 336: 682-692. 10.1124/jpet.110.176743View ArticleGoogle Scholar
- Monks TJ, Jones DC: The metabolism and toxicity of quinones, quinonimines, quinone methides, and quinone-thioethers. Curr Drug Metab 2002, 3: 425-438. 10.2174/1389200023337388View ArticleGoogle Scholar
- Montini G, Malaventura C, Salviati L: Early coenzyme Q10 supplementation in primary coenzyme Q10 deficiency. N Engl J Med 2008, 358: 2849-2850. 10.1056/NEJMc0800582View ArticleGoogle Scholar
- Morre DJ, Morre DM: Non-mitochondrial coenzyme Q. Biofactors 2011, 37: 355-360. 10.1002/biof.156View ArticleGoogle Scholar
- Mukhopadhyay P, Horvath B, Zsengeller Z: Mitochondrial-targeted antioxidants represent a promising approach for prevention of cisplatin-induced nephropathy. Free Radic Biol Med 2012, 52: 497-506. 10.1016/j.freeradbiomed.2011.11.001View ArticleGoogle Scholar
- Nagase M, Matsui H, Shibata S: Salt-induced nephropathy in obese spontaneously hypertensive rats via paradoxical activation of the mineralocorticoid receptor: role of oxidative stress. Hypertension 2007, 50: 877-883. 10.1161/HYPERTENSIONAHA.107.091058View ArticleGoogle Scholar
- Nangaku M: Chronic hypoxia and tubulointerstitial injury: a final common pathway to end-stage renal failure. J Am Soc Nephrol 2006, 17: 17-25.View ArticleGoogle Scholar
- Ogasawara Y, Umezu N, Ishii K: DNA damage in human pleural mesothelial cells induced by exposure to carbon nanotubes. Nihon Eiseigaku Zasshi 2012, 67: 76-83. 10.1265/jjh.67.76View ArticleGoogle Scholar
- Okamura DM, Himmelfarb J: Tipping the redox balance of oxidative stress in fibrogenic pathways in chronic kidney disease. Pediatr Nephrol 2009, 24: 2309-2319. 10.1007/s00467-009-1199-5View ArticleGoogle Scholar
- Orient A, Donko A, Szabo A: Novel sources of reactive oxygen species in the human body. Nephrol Dial Transplant 2007, 22: 1281-1288. 10.1093/ndt/gfm077View ArticleGoogle Scholar
- Oudemans-van Straaten HM: Strategies to prevent contrast nephropathy. Minerva Cardioangiol 2005, 53: 445-463.Google Scholar
- Perez-Sanchez C, Ruiz-Limon P, Aguirre MA: Mitochondrial dysfunction in antiphospholipid syndrome: implications in the pathogenesis of the disease and effects of coenzyme Q(10) treatment. Blood 2012, 119: 5859-5870. 10.1182/blood-2011-12-400986View ArticleGoogle Scholar
- Qu HY, Gao HZ, Hao GT: Single-dose safety, pharmacokinetics, and food effects studies of compound naphthoquine phosphate tablets in healthy volunteers. J Clin Pharmacol 2010, 50: 1310-1318. 10.1177/0091270009356296View ArticleGoogle Scholar
- Quinzii CM, Hirano M: Coenzyme Q and mitochondrial disease. Dev Disabil Res Rev 2010, 16: 183-188. 10.1002/ddrr.108View ArticleGoogle Scholar
- Ragheb A, Attia A, Eldin WS: The protective effect of thymoquinone, an anti-oxidant and anti-inflammatory agent, against renal injury: a review. Saudi J Kidney Dis Transpl 2009, 20: 741-752.Google Scholar
- Rakoczi K, Klivenyi P, Vecsei L: Neuroprotection in Parkinson's disease and other neurodegenerative disorders: preclinical and clinical findings. Ideggyogy Sz 2009, 62: 25-34.Google Scholar
- Ralph SJ, Low P, Dong L: Mitocans: mitochondrial targeted anti-cancer drugs as improved therapies and related patent documents. Recent Pat Anticancer Drug Discov 2006, 1: 327-346. 10.2174/157489206778776952View ArticleGoogle Scholar
- Ralph SJ, Moreno-Sanchez R, Neuzil J: Inhibitors of succinate: quinone reductase/Complex II regulate production of mitochondrial reactive oxygen species and protect normal cells from ischemic damage but induce specific cancer cell death. Pharm Res 2011, 28: 2695-2730. 10.1007/s11095-011-0566-7View ArticleGoogle Scholar
- Rich PR, Bendall DS: A mechanism for the reduction of cytochromes by quinols in solution and its relevance to biological electron transfer reactions. FEBS Lett 1979, 105: 189-194. 10.1016/0014-5793(79)80608-0View ArticleGoogle Scholar
- Ross D, Kepa JK, Winski SL: NAD(P)H:quinone oxidoreductase 1 (NQO1): chemoprotection, bioactivation, gene regulation and genetic polymorphisms. Chem Biol Interact 2000, 129: 77-97. 10.1016/S0009-2797(00)00199-XView ArticleGoogle Scholar
- Sagar S, Kaur M, Minneman KP: Anti-cancer activities of diospyrin, its derivatives and analogues. Eur J Med Chem 2010, 45: 3519-3530. 10.1016/j.ejmech.2010.06.021View ArticleGoogle Scholar
- Sakata T, Furuya R, Shimazu T: Coenzyme Q10 administration suppresses both oxidative and antioxidative markers in hemodialysis patients. Blood Purif 2008, 26: 371-378. 10.1159/000135605View ArticleGoogle Scholar
- Sakatsume M, Kadomura M, Sakata I: Novel glomerular lipoprotein deposits associated with apolipoprotein E2 homozygosity. Kidney Int 2001, 59: 1911-1918. 10.1046/j.1523-1755.2001.0590051911.xView ArticleGoogle Scholar
- Salviati L, Sacconi S, Murer L: Infantile encephalomyopathy and nephropathy with CoQ10 deficiency: a CoQ10-responsive condition. Neurology 2005, 65: 606-608. 10.1212/01.wnl.0000172859.55579.a7View ArticleGoogle Scholar
- Sankaranarayanan C, Pari L: Thymoquinone ameliorates chemical induced oxidative stress and beta-cell damage in experimental hyperglycemic rats. Chem Biol Interact 2011, 190: 148-154. 10.1016/j.cbi.2011.02.029View ArticleGoogle Scholar
- Sayed-Ahmed MM, Nagi MN: Thymoquinone supplementation prevents the development of gentamicin-induced acute renal toxicity in rats. Clin Exp Pharmacol Physiol 2007, 34: 399-405. 10.1111/j.1440-1681.2007.04560.xView ArticleGoogle Scholar
- Siegel D, Yan C, Ross D: NAD(P)H:quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinones. Biochem Pharmacol 2012, 83: 1033-1040. 10.1016/j.bcp.2011.12.017View ArticleGoogle Scholar
- Singbartl K, Kellum JA: AKI in the ICU: definition, epidemiology, risk stratification, and outcomes. Kidney Int 2012, 81: 819-825. 10.1038/ki.2011.339View ArticleGoogle Scholar
- Skulachev VP, Anisimov VN, Antonenko YN: An attempt to prevent senescence: a mitochondrial approach. Biochim Biophys Acta 2009, 1787: 437-461. 10.1016/j.bbabio.2008.12.008View ArticleGoogle Scholar
- Skulachev MV, Antonenko YN, Anisimov VN: Mitochondrial-targeted plastoquinone derivatives. Effect on senescence and acute age-related pathologies. Curr Drug Targets 2011, 12: 800-826. 10.2174/138945011795528859View ArticleGoogle Scholar
- Soares J, Keppler BR, Wang X: Ortho-Quinone tanshinones directly inhibit telomerase through an oxidative mechanism mediated by hydrogen peroxide. Bioorg Med Chem Lett 2011, 21: 7474-7478. 10.1016/j.bmcl.2011.09.112View ArticleGoogle Scholar
- Stowell MHB, McPhillips TM, Rees DC: Light-induced structural changes in photosynthetic reaction center: implications for mechanism of electron-proton transfer. Science 1997, 276: 812-816. 10.1126/science.276.5313.812View ArticleGoogle Scholar
- Syed S, Zubair A, Frieri M: Immune response to nanomaterials: implications for medicine and literature review. Curr Allergy Asthma Rep 2012, 13(1):50-57.View ArticleGoogle Scholar
- Tamura Y, Tanabe K, Kitagawa W: Nicorandil, a Katp channel opener, alleviates chronic renal injury by targeting podocytes and macrophages. Am J Physiol Renal Physiol 2012, 303: F339-F349. 10.1152/ajprenal.00158.2012View ArticleGoogle Scholar
- Thurnherr T, Brandenberger C, Fischer K: A comparison of acute and long-term effects of industrial multiwalled carbon nanotubes on human lung and immune cells in vitro. Toxicol Lett 2011, 200: 176-186. 10.1016/j.toxlet.2010.11.012View ArticleGoogle Scholar
- Tsai KL, Chen LH, Chiou SH: Coenzyme Q10 suppresses oxLDL-induced endothelial oxidative injuries by the modulation of LOX-1-mediated ROS generation via the AMPK/PKC/NADPH oxidase signaling pathway. Mol Nutr Food Res 2011, 55(Suppl 2):S227-S240.View ArticleGoogle Scholar
- Varagic J, Ahmad S, Brosnihan KB: Salt-induced renal injury in spontaneously hypertensive rats: effects of nebivolol. Am J Nephrol 2010, 32: 557-566. 10.1159/000321471View ArticleGoogle Scholar
- Verrax J, Beck R, Dejeans N: Redox-active quinones and ascorbate: an innovative cancer therapy that exploits the vulnerability of cancer cells to oxidative stress. Anticancer Agents Med Chem 2011, 11: 213-221. 10.2174/187152011795255902View ArticleGoogle Scholar
- Villalba JM, Parrado C, Santos-Gonzalez M: Therapeutic use of coenzyme Q10 and coenzyme Q10-related compounds and formulations. Expert Opin Investig Drugs 2010, 19: 535-554. 10.1517/13543781003727495View ArticleGoogle Scholar
- Yang X, Dai G, Li G: Coenzyme Q10 reduces beta-amyloid plaque in an APP/PS1 transgenic mouse model of Alzheimer's disease. J Mol Neurosci 2010, 41: 110-113. 10.1007/s12031-009-9297-1View ArticleGoogle Scholar
- Yankovskaya V, Horsefield R, Tornroth S: Architecture of succinate dehydrogenase and reactive oxygen species generation. Science 2003, 299: 700-704. 10.1126/science.1079605View ArticleGoogle Scholar
- Zahid M, Saeed M, Rogan EG: Benzene and dopamine catechol quinones could initiate cancer or neurogenic disease. Free Radic Biol Med 2010, 48: 318-324. 10.1016/j.freeradbiomed.2009.11.002View ArticleGoogle Scholar
- Zappa F, Ward T, Pedrinis E: NAD(P)H: quinone oxidoreductase 1 expression in kidney podocytes. J Histochem Cytochem 2003, 51: 297-302. 10.1177/002215540305100304View ArticleGoogle Scholar
- Zhou Y, Cierpicki T, Jimenez RH: NMR solution structure of the integral membrane enzyme DsbB: functional insights into DsbB-catalyzed disulfide bond formation. Mol Cell 2008, 31: 896-908. 10.1016/j.molcel.2008.08.028View ArticleGoogle Scholar
- Zhu Z, Gunner MR: Energetics of quinone-dependent electron and proton transfers in Rhodobacter sphaeroides photosynthetic reaction centers. Biochemistry 2005, 44: 82-96. 10.1021/bi048348kView ArticleGoogle Scholar
- Zubair A, Frieri M: Role of nuclear factor-ĸB in breast and colorectal cancer. Curr Allergy Asthma Rep 2013, 13: 44-49. 10.1007/s11882-012-0300-5View ArticleGoogle Scholar
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