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  1. We developed a semi-automated tool to assess mammographic density (MD), a phenotype risk marker for breast cancer (BC), in full-field digital images and evaluated its performance testing its reproducibility, c...

    Authors: Marina Pollán, Rafael Llobet, Josefa Miranda-García, Joaquín Antón, María Casals, Inmaculada Martínez, Carmen Palop, Francisco Ruiz-Perales, Carmen Sánchez-Contador, Carmen Vidal, Beatriz Pérez-Gómez and Dolores Salas-Trejo
    Citation: SpringerPlus 2013 2:242
  2. We previously described a menstrual heat cycle of the breast in four groups of women (healthy, family history of breast cancer, benign breast disease, ‘cancer-associated’) who wore a thermometric brassiere (Ch...

    Authors: Hugh W Simpson, David George, Robert B Sothern and Keith Griffiths
    Citation: SpringerPlus 2013 2:241
  3. Data on body size and postmenopausal breast cancer in Hispanic and African American women are inconsistent, possibly due to the influence of modifying factors. We examined associations between adiposity and ri...

    Authors: Esther M John, Amanda I Phipps and Meera Sangaramoorthy
    Citation: SpringerPlus 2013 2:239
  4. Early diagnosis of lung cancers and distinction between the tumor types (Small Cell Lung Cancer (SCLC) and Non-Small Cell Lung Cancer (NSCLC) are very important to increase the survival rate of patients. Herei...

    Authors: Faezeh Hosseinzadeh, Amir Hossein KayvanJoo, Mansuor Ebrahimi and Bahram Goliaei
    Citation: SpringerPlus 2013 2:238
  5. This Phase I study aimed to assess the potential drug-drug interactions (pharmacokinetic [PK] and safety profile) of Δ9-tetrahydrocannabinol (THC)/cannabidiol (CBD) oromucosal spray (Sativex ®, nabiximols) in com...

    Authors: Colin Stott, Linda White, Stephen Wright, Darren Wilbraham and Geoffrey Guy
    Citation: SpringerPlus 2013 2:236
  6. Methods for human skin gene therapy requires efficient and stable introduction of genes into skin cells. Transient cutaneous gene therapy is an attractive approach in the treatment of skin diseases. The ‘Achil...

    Authors: Matthias Schulte, Michael Sorkin, Sammy Al-Benna, Jadwiga Stupka, Tobias Hirsch, Adrien Daigeler, Marco Rainer Kesting, Hans-Ulrich Steinau, Frank Jacobsen and Lars Steinstraesser
    Citation: SpringerPlus 2013 2:234
  7. Coastal line is now polluted by many kinds of sewage including heavy metals discharged by intensive human activities. Cadmium is a nonessential heavy metal for organisms and can cause many kinds of adverse eff...

    Authors: Ming Cong, Jiasen Lv, Xiaoli Liu, Jianmin Zhao and Huifeng Wu
    Citation: SpringerPlus 2013 2:232
  8. Globally, trauma represents a growing and significant burden of disease. Many health systems have limited metrics with which to guide development and appropriately inform policy and management decisions with r...

    Authors: Stephen C Morris, Nicolas Manice, Taylor Nelp and Tashi Tenzin
    Citation: SpringerPlus 2013 2:231
  9. This article presents the ability of an omnibus permutation test on ensembles of two-locus analyses (2LOmb) to detect pure epistasis in the presence of genetic heterogeneity. The performance of 2LOmb is evalua...

    Authors: Damrongrit Setsirichok, Phuwadej Tienboon, Nattapong Jaroonruang, Somkit Kittichaijaroen, Waranyu Wongseree, Theera Piroonratana, Touchpong Usavanarong, Chanin Limwongse, Chatchawit Aporntewan, Marong Phadoongsidhi and Nachol Chaiyaratana
    Citation: SpringerPlus 2013 2:230
  10. Metabolic rates can increase 21 times above resting levels during cycling with the majority attributed to muscular contractions. Metabolic estimates attained through gas exchange parameters are limited by the ...

    Authors: Ollie M Blake and James M Wakeling
    Citation: SpringerPlus 2013 2:229
  11. The Eastern Himalayan region of Northeast (NE) India is home to a large number of indigenous rice varieties, which may serve as a valuable genetic resource for future crop improvement to meet the ever-increasi...

    Authors: Baharul Choudhury, Mohamed Latif Khan and Selvadurai Dayanandan
    Citation: SpringerPlus 2013 2:228
  12. Project management of product/service orders has become a mode of operation in many companies. Although these are mostly cyclically recurring projects, risk management is very important for them. An extended r...

    Authors: Janez Kušar, Lidija Rihar, Urban Žargi and Marko Starbek
    Citation: SpringerPlus 2013 2:227
  13. Although complete decongestive therapy (CDT) is considered to reduce the volume of lymphedema, there is no concrete evidence to sustain its efficacy. The purpose of the present study was to find new evidence o...

    Authors: Yukari Takeno, Hiromi Arita and Etsuko Fujimoto
    Citation: SpringerPlus 2013 2:225
  14. The unique ability of Argyroneta aquatica to form a diving bell web was re-examined using a new approach in a structurally simplified environment. The spiders generated sheet-webs from stiff, anchored threads and...

    Authors: Dietrich Neumann and Armin Kureck
    Citation: SpringerPlus 2013 2:223
  15. The impact of missing data on quantitative research can be serious, leading to biased estimates of parameters, loss of information, decreased statistical power, increased standard errors, and weakened generali...

    Authors: Yiran Dong and Chao-Ying Joanne Peng
    Citation: SpringerPlus 2013 2:222
  16. Moderately preterm birth seems to be an evolutional risk condition at cognitive, behavioural and socio-relational levels. The study is aimed to investigate the likely occurrence of precursors of Attention Defi...

    Authors: Giovanna Perricone, M Regina Morales and Germana Anzalone
    Citation: SpringerPlus 2013 2:221
  17. In this paper we present the development and usability of an electronic health record (EHR) system in a comprehensive dental clinic.The graphic user interface of the system was designed to consider the concept...

    Authors: Siriwan Suebnukarn, Pawornwan Rittipakorn, Budsara Thongyoi, Kwanwong Boonpitak, Mansuang Wongsapai and Panu Pakdeesan
    Citation: SpringerPlus 2013 2:220
  18. A review of 66 patients underwent LSG in our institution. 25 patients were excluded as they had no postoperative vitamin B12 screening. 41 patients were included as screened for vitamin B12 and other micronutr...

    Authors: Amar M Eltweri, David J Bowrey, Christopher D Sutton, Lisa Graham and Robert N Williams
    Citation: SpringerPlus 2013 2:218
  19. The rapid urbanization in Delhi has resulted in a tremendous increase in the number of motor vehicles with the increase in population and urban mobilization. The vehicular traffic is now recognized as one of t...

    Authors: Pramila Goyal, Dhirendra Mishra and Anikender Kumar
    Citation: SpringerPlus 2013 2:216
  20. Vascular endothelium expresses both the estrogen receptors (ERs) α and β, and ERα mediates development of early atherosclerosis in male mice. This process is thought to be testosterone-dependent. We hypothesiz...

    Authors: Amparo C Villablanca, Sarada Tetali, Robin Altman, Kenneth F Ng and John C Rutledge
    Citation: SpringerPlus 2013 2:214
  21. It has been postulated that human tendons are viscoelastic and their mechanical properties time-dependent. Although Achilles tendon (AT) mechanics are widely reported, there is no consensus about AT viscoelast...

    Authors: Jussi Peltonen, Neil J Cronin, Lauri Stenroth, Taija Finni and Janne Avela
    Citation: SpringerPlus 2013 2:212
  22. Sorption of aspartic and glutamic aminoacids by regeneration of calcined hydrotalcite is reported. Hydrotalcite was synthesized by coprecipitation and calcined at 773 K. Sorption experiments were performed at ...

    Authors: Fabiano Silvério, Márcio José dos Reis, Jairo Tronto and João Barros Valim
    Citation: SpringerPlus 2013 2:211
  23. Woody plants are particularly difficult to investigate due to high phenolic, resin, and tannin contents and laborious sample preparation. In particular, protein isolation from woody plants for two-dimensional ...

    Authors: Mónica Sebastiana, Andreia Figueiredo, Filipa Monteiro, Joana Martins, Catarina Franco, Ana Varela Coelho, Fátima Vaz, Tânia Simões, Deborah Penque, Maria Salomé Pais and Sílvia Ferreira
    Citation: SpringerPlus 2013 2:210
  24. To evaluate dose reduction and image quality of abdominopelvic computed tomography (CT) reconstructed with model-based iterative reconstruction (MBIR) compared to adaptive statistical iterative reconstruction ...

    Authors: Koichiro Yasaka, Masaki Katsura, Masaaki Akahane, Jiro Sato, Izuru Matsuda and Kuni Ohtomo
    Citation: SpringerPlus 2013 2:209
  25. A novel bacterial isolate capable of growth on trichloroethylene as the sole carbon source was identified as Stenotrophomonas maltophilia PM102 by 16S rDNA sequencing (GenBank Acc.no. JQ797560). Serum was obtaine...

    Authors: Piyali Mukherjee and Pranab Roy
    Citation: SpringerPlus 2013 2:207
  26. The present study has evaluated the association of growth differentiation factor9 (GDF9) and bone morphogenetic protein15 (BMP15) mRNA expression in cumulus-oocyte complexes (COCs) of buffalo ovary during in vitr...

    Authors: Muralidharan Kathirvel, Eswari Soundian and Vijayarani Kumanan
    Citation: SpringerPlus 2013 2:206
  27. We present a data based statistical study on the effects of seasonal variations in the growth rates of the gastro-intestinal (GI) parasitic infection in livestock. The alluded growth rate is estimated through ...

    Authors: Amit K Chattopadhyay and Subhasish Bandyopadhyay
    Citation: SpringerPlus 2013 2:205
  28. Bevacizumab, a humanized monoclonal antibody directed against vascular endothelial growth factor, is an effective and well-tolerated treatment option for patients with breast cancer. Bevacizumab has demonstrat...

    Authors: Vibeke Kruse, Hannelore Denys, Rudy Van Den Broecke, Simon Van Belle and Veronique Cocquyt
    Citation: SpringerPlus 2013 2:202
  29. A Never Born protein is a theoretical protein which does not occur in nature. The reason why some proteins were selected and some were not during evolution is not known. We applied information theory to find s...

    Authors: Grzegorz Szoniec and Maciej J Ogorzalek
    Citation: SpringerPlus 2013 2:200
  30. The authors developed a computerized program designed to diagnose primary headache based on international classification of headache disorders, 2nd edition (ICHD-II) criteria for use by physicians.

    Authors: Vahid Eslami, Sadreddin Rouhani-Esfahani, Nima Hafezi-Nejad, Farshid Refaeian, Siamak Abdi and Mansoureh Togha
    Citation: SpringerPlus 2013 2:199
  31. The primary objective of the present study was to show the long lasting cardioprotective activity, at different time-points, up to 18 month-follow-up, of telmisartan in preserving the systolic function (assess...

    Authors: Mariele Dessì, Clelia Madeddu, Alessandra Piras, Christian Cadeddu, Giorgia Antoni, Giuseppe Mercuro and Giovanni Mantovani
    Citation: SpringerPlus 2013 2:198
  32. The present study was carried out to study the effect of different dosages of β-glucan suspension on immune response and disease resistance in Anabas testudineus spawns against a fungal pathogen Saprolegnia paras...

    Authors: Basanta Kumar Das, Pranati Pattnaik, Chandan Debnath, Dipak Kumar Swain and Jyotirmayee Pradhan
    Citation: SpringerPlus 2013 2:197
  33. Computed tomography (CT)-guided lung biopsy is commonly used to make a histological diagnosis for pulmonary lesions. Its most common complication is pneumothorax. While it is thought that CT-guided lung biopsy...

    Authors: Nobuhiro Asai, Yasutaka Kawamura, Ikuo Yamazaki, Keiji Sogawa, Yoshihiro Ohkuni, Toshihiro O’uchi, Akihito Kubo, Etsuro Yamaguchi and Norihiro Kaneko
    Citation: SpringerPlus 2013 2:196
  34. A bioequivalence study was proved of generic Febuxostat 80 mg tablets (T) in healthy volunteers.For this purpose, Authors developed a simple, sensitive, selective, rapid, rugged and reproducible liquid chromat...

    Authors: Babu Rao Chandu, Kanchanamala Kanala, Nagiat T Hwisa, Prakash Katakam and Mukkanti Khagga
    Citation: SpringerPlus 2013 2:194
  35. The CFD simulation of heat transfer characteristics of a nanofluid in a circular tube under constant heat flux was considered using Fluent software (version 6.3.26) in the laminar flow. Al2O3 nanoparticles in wat...

    Authors: Reza Davarnejad, Sara Barati and Maryam Kooshki
    Citation: SpringerPlus 2013 2:192
  36. Yolk-sac fry of Goldfish (Carassius auratus gibelio) were exposed to various concentrations of Al and pH for 3, 7 and 10 days. In this study number of dead fish, total length of larvae, yolk sac length, swimming ...

    Authors: Vahid Taghizadeh, Mohammad Reza Imanpoor, Mahboubeh Hosseinzadeh and Hajar Azarin
    Citation: SpringerPlus 2013 2:190