Correlations of microRNA-124a and microRNA-30d with clinicopathological features of breast cancer patients with type 2 diabetes mellitus

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Table 2 Comparisons of clinical features and biochemical parameters between diabetic group and non-diabetic group

	Diabetic group (n = 72)	Non-diabetic group (n = 144)	t/χ²	P value
Age (years)	52.72 ± 6.23	50.08 ± 4.76	3.113	<0.001
Family history of BC	5.56% (4)	4.17% (6)	0.458	0.647
Underlying diseases	19.44% (14)	20.83% (30)	0.057	0.811
Ratio of menopause	76.39% (55)	55.56% (80)	8.889	0.003
BMI (Kg/m²)	24.68 ± 4.74	23.21 ± 3.25	2.673	0.008
SBP (mmHg)	124.68 ± 10.35	125.36 ± 11.23	0.430	0.667
DBP (mmHg)	78.36 ± 7.93	80.57 ± 8.54	1.835	0.068
HDL-C (mmol/L)	1.21 ± 0.32	1.31 ± 0.36	1.995	0.047
LDL-C (mmol/L)	3.85 ± 0.74	3.12 ± 0.65	7.425	<0.001
TG (mmol/L)	1.32 ± 0.35	1.41 ± 0.41	1.594	0.112
TC (mmol/L)	4.45 ± 0.87	3.64 ± 0.68	7.498	<0.0001
FPG (mmol/L)	8.32 ± 0.73	5.27 ± 0.43	38.56	<0.001
2hPG (mmol/L)	14.68 ± 1.02	5.58 ± 0.47	89.810	<0.001
HbA1c (%)	10.57 ± 2.11	5.64 ± 1.57	19.320	<0.001
FIns (uU/mL)	10.14 ± 3.25	5.33 ± 1.87	6.954	<0.001
HOMA-IS	42.84 ± 14.53	60.50 ± 16.29	7.779	<0.001
HOMA-IR	3.75 ± 1.25	1.27 ± 0.50	20.750	<0.001
E₂ (pg/mL)	50.20 ± 11.40	23.66 ± 8.63	19.080	<0.001

Comparisons on family history of BC, underlying diseases and the ratio of menopause between the two groups were measured by χ² test; BMI, weight (kg)/height (m²); Normal BMI, 18.5–22.9 kg/m²
Diabetic group, breast cancer patients with type 2 diabetes mellitus; Non-diabetic group, breast cancer patients without type 2 diabetes mellitus
BC breast cancer, BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, TG triglyceride, TC total cholesterol, FPG fasting blood glucose, 2hPG 2-hour postprandial blood glucose, HbA1c glycosylated hemoglobin, FIns fasting insulin, HOMA-IR homeostasis model assessment of insulin resistance, HOMA-IS HOMA of β-cell insulin secretion, E ₂ estradiol