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Table 2 Validation parameters of linearity, accuracy, precision and LLOQ for each analyte

From: Effect of various anticoagulants on the bioanalysis of drugs in rat blood: implication for pharmacokinetic studies of anticancer drugs

Analyte

Linearity range (μg/mL)

Accuracy*

Precision* (CV %)

LLOQ (μg/mL)

Erlotinib

0.1–10

95.6–98.7

3.7–10.5

0.1

Pemetrexed

0.1–10

96.2–101.1

2.9–12.1

0.1

Voriconazole

0.25–8

100.4–102.3

6.0–9.7

0.25

Imatinib

0.1–10

103.3–101.7

3.4–5.7

0.1

6MP

0.1–10

102.4–107.4

4.6–6.1

0.1

Meropenem

0.1–10

89.5–97.2

4.3–4.5

0.1

  1. CV coefficient of variation, LLOQ lower limit of quantitation
  2. * Range of accuracy and precision values shown for low, medium and high QC samples
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