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Table 1 Summary of selected studies mentioned in this article

From: The prognostic factors for patients with hematological malignancies admitted to the intensive care unit

References

Country

Region

First author

Patients and sample size

Significant prognostic factors

Organ failure

Scoring systems

ICU mortality (%)

Hospital mortality (%)

6-month mortality (%)

Lloyd-Thomas et al. (1988)

UK

Europe

Lloyd-Thomas

HM

N = 60

The dysfunction of an increasing number of organ systems, an APACHE II score of greater than 30, failure of the malignancy to respond to chemotherapy, and persistent leucopenia all

  

78

  

Yau et al. (1991)

UK

Europe

Yaul

HM

N = 92

The nature and progress of the underlying malignancy

 

APACHE II: 25.9

 

77

 

Evison et al.(2001)

Switzerland

Europe

Evison

HM

N = 78

Multi-organ failure and evidence of liver damage

47% required vasopressors; 43% required MV

APACHE II:18

26

  

Kroschinsky et al. (2002)

Germany

Europe

Kroschinsky

HM

N = 104

mechanical ventilation, SAPS II

52% required MV

SAPS II: 46

44

 

63

Benoit et al. (2003)

Belgium

Europe

Benoit

HM

N = 124

Leukopenia, vasopressors, urea of >0.75 g/L at admission, recent bacteremia

54% required ventilation; 54% required pressors

APACHE II: 26 ± 7.7; SAPS II: 53 ± 17.8

42

54

66

Rabbat et al. (2005)

France

Europe

Rabbat

HM

N = 83

Simplified acute physiology score II and need for IMV

47% required IMV

SAPS II 54.9 ± 26.7

34

  

Lamia et al. (2006)

France

Europe

Lamia

HM

N = 92

Severity and three organ failure scores on day 1 and Delta scores

41% required IMV; 50% required pressors

SOFA: 9 ± 5

SAPS II:60 ± 22

 

58

 

Verplancke et al. (2008)

Belgium

Europe

Verplancke

HM

N = 352

–

49% Required IMV; 41% required pressors

APACHE II: 24.5 ± 7.4

 

54.4

 

Ferrà et al. (2008)

Spain

Europe

Ferrà

HM

N = 116

Need of mechanical ventilation, cardiovascular vasoactive drugs

  

54

  

Merz et al. (2008)

Australia

Oceania

Merz

HM

N = 101

SAPS II at ICU admission, Mechanical ventilation, Renal replacement therapy, ICU length of stay

55.3% required MV

 

33.7

  

Hampshire et al. (2009)

UK

Europe

Hampshire

HM

N = 7689

Bone marrow transplant, Hodgkin’s lymphoma, severe sepsis, age, length of hospital stay prior to intensive care admission, tachycardia, low systolic blood pressuretachypnoea, low Glasgow Coma Score, sedation, PaO2:FiO2, acidaemia, alkalaemia, oliguria, hyponatraemia, hypernatraemia, low haematocrit, and uraemia

 

APACHE II: 24.4 ± 7.9

43.1

59.2

 

Geerse et al. (2011)

Netherland

Europe

Geerse

HM

N = 86

Organ failure, a need for mechanical ventilation or inotropic/vasopressor therapy

52% required IMV, 52% required pressors

APACHE II:28.8 ± 7.9

SOFA:10.1 ± 3.4

56

65

 

Turkoglu et al. (2011)

Turkey

Asia

Turkoglu

HM

N = 128

Low Glasgow coma scale, prior immunosuppressive treatment, neutropenia, IMV, and severe sepsis

64% required IMV

APACHE II:24

65

70

 

Bird et al. (2012)

UK

Europe

Bird

HM

N = 199

Mechanical ventilation;≥2 organ failures

51.9% required IMV; 51.5% required pressors

APACHE II:21

33.7

45.7

59.3

Yeo et al. (2012)

South Korea

Asia

Yeo

HM

N = 227

Acute leukemia, need for invasive mechanical ventilator, use of inotropic/vasopressor agents, and Acute Physiology, Chronic Health Evaluation II scores

48% required IMV; 54.6% required inotropes

APACHE II: 19.4 ± 0.5

84.1

89.9

 

Namendys-Silva et al. (2013)

Mexico

America

Namendys-Silva

HM

N = 102

Neutropenia at the time of ICU admission, the need for vasopressors, need for invasive mechanical ventilation, serum creatinine > 106 μmol/L

85.3% required IMV; 77.5% required pressors

SOFA: 9.8 ± 4;

APACHE:17.5 ± 6;

SAPS II: 42.5 ± 15.3

46.1

57.8

 

Hill et al. (2013)

UK

Europe

Hill

HM

N = 147

Culture proven infection, age, MV and inotropes

  

56

79

 

McCaughey et al. (2013)

UK

Europe

McCaughey

HM

N = 21

(APACHE II) scores, and decreased requirements for invasive ventilation and inotropic support

 

APACHE II:23

43

 

67

Azoulay et al. (2013)

France

Europe

Azoulay

HM

N = 1011

Cancer remission; time to ICU admission less than 24 h, poor performance status, Charlson comorbidity index, allogeneic HSCT, organ dysfunction score, cardiac arrest, acute respiratory failure, malignant organ infiltration, invasive aspergillosis

47.9% required IMV, 51.2% required pressors

  

60.7

 

Townsend et al. (2013)

UK

Europe

Townsend

HM

allo-HSCT

N = 213

The need for ventilation

50% required MV;45% required pressors

APACHE II: 23

68.0

  

Sawicka et al. (2014)

Poland

Europe

Sawicka

HM

N = 99

SAPS II

  

75.7

  

Khwankeaw and Bhurayanontachai (2014)

Thailand

Asia

Khwankeaw

HM

N = 145

Mechanical ventilation, the use of vasopressors and the APACHE II scores

  

55.2

  

Liu et al. (2015)

China

Asia

Liu and Cheng

HM

N = 121

The use of IMV, APACH II at admission, SOFA trend

64.5% required IMV, 67.8% required pressors

APACHE II:20.84 ± 0.89

SOFA:10.75 ± 0.48

60.3

 

90.9