References | Country | Region | First author | Patients and sample size | Significant prognostic factors | Organ failure | Scoring systems | ICU mortality (%) | Hospital mortality (%) | 6-month mortality (%) |
---|---|---|---|---|---|---|---|---|---|---|
Lloyd-Thomas et al. (1988) | UK | Europe | Lloyd-Thomas | HM NÂ =Â 60 | The dysfunction of an increasing number of organ systems, an APACHE II score of greater than 30, failure of the malignancy to respond to chemotherapy, and persistent leucopenia all | Â | Â | 78 | Â | Â |
Yau et al. (1991) | UK | Europe | Yaul | HM NÂ =Â 92 | The nature and progress of the underlying malignancy | Â | APACHE II: 25.9 | Â | 77 | Â |
Evison et al.(2001) | Switzerland | Europe | Evison | HM NÂ =Â 78 | Multi-organ failure and evidence of liver damage | 47% required vasopressors; 43% required MV | APACHE II:18 | 26 | Â | Â |
Kroschinsky et al. (2002) | Germany | Europe | Kroschinsky | HM NÂ =Â 104 | mechanical ventilation, SAPS II | 52% required MV | SAPS II: 46 | 44 | Â | 63 |
Benoit et al. (2003) | Belgium | Europe | Benoit | HM N = 124 | Leukopenia, vasopressors, urea of >0.75 g/L at admission, recent bacteremia | 54% required ventilation; 54% required pressors | APACHE II: 26 ± 7.7; SAPS II: 53 ± 17.8 | 42 | 54 | 66 |
Rabbat et al. (2005) | France | Europe | Rabbat | HM N = 83 | Simplified acute physiology score II and need for IMV | 47% required IMV | SAPS II 54.9 ± 26.7 | 34 |  |  |
Lamia et al. (2006) | France | Europe | Lamia | HM N = 92 | Severity and three organ failure scores on day 1 and Delta scores | 41% required IMV; 50% required pressors | SOFA: 9 ± 5 SAPS II:60 ± 22 |  | 58 |  |
Verplancke et al. (2008) | Belgium | Europe | Verplancke | HM N = 352 | – | 49% Required IMV; 41% required pressors | APACHE II: 24.5 ± 7.4 |  | 54.4 |  |
Ferrà et al. (2008) | Spain | Europe | Ferrà | HM N = 116 | Need of mechanical ventilation, cardiovascular vasoactive drugs |  |  | 54 |  |  |
Merz et al. (2008) | Australia | Oceania | Merz | HM NÂ =Â 101 | SAPS II at ICU admission, Mechanical ventilation, Renal replacement therapy, ICU length of stay | 55.3% required MV | Â | 33.7 | Â | Â |
Hampshire et al. (2009) | UK | Europe | Hampshire | HM N = 7689 | Bone marrow transplant, Hodgkin’s lymphoma, severe sepsis, age, length of hospital stay prior to intensive care admission, tachycardia, low systolic blood pressuretachypnoea, low Glasgow Coma Score, sedation, PaO2:FiO2, acidaemia, alkalaemia, oliguria, hyponatraemia, hypernatraemia, low haematocrit, and uraemia |  | APACHE II: 24.4 ± 7.9 | 43.1 | 59.2 |  |
Geerse et al. (2011) | Netherland | Europe | Geerse | HM N = 86 | Organ failure, a need for mechanical ventilation or inotropic/vasopressor therapy | 52% required IMV, 52% required pressors | APACHE II:28.8 ± 7.9 SOFA:10.1 ± 3.4 | 56 | 65 |  |
Turkoglu et al. (2011) | Turkey | Asia | Turkoglu | HM NÂ =Â 128 | Low Glasgow coma scale, prior immunosuppressive treatment, neutropenia, IMV, and severe sepsis | 64% required IMV | APACHE II:24 | 65 | 70 | Â |
Bird et al. (2012) | UK | Europe | Bird | HM N = 199 | Mechanical ventilation;≥2 organ failures | 51.9% required IMV; 51.5% required pressors | APACHE II:21 | 33.7 | 45.7 | 59.3 |
Yeo et al. (2012) | South Korea | Asia | Yeo | HM N = 227 | Acute leukemia, need for invasive mechanical ventilator, use of inotropic/vasopressor agents, and Acute Physiology, Chronic Health Evaluation II scores | 48% required IMV; 54.6% required inotropes | APACHE II: 19.4 ± 0.5 | 84.1 | 89.9 |  |
Namendys-Silva et al. (2013) | Mexico | America | Namendys-Silva | HM N = 102 | Neutropenia at the time of ICU admission, the need for vasopressors, need for invasive mechanical ventilation, serum creatinine > 106 μmol/L | 85.3% required IMV; 77.5% required pressors | SOFA: 9.8 ± 4; APACHE:17.5 ± 6; SAPS II: 42.5 ± 15.3 | 46.1 | 57.8 |  |
Hill et al. (2013) | UK | Europe | Hill | HM NÂ =Â 147 | Culture proven infection, age, MV and inotropes | Â | Â | 56 | 79 | Â |
McCaughey et al. (2013) | UK | Europe | McCaughey | HM NÂ =Â 21 | (APACHE II) scores, and decreased requirements for invasive ventilation and inotropic support | Â | APACHE II:23 | 43 | Â | 67 |
Azoulay et al. (2013) | France | Europe | Azoulay | HM NÂ =Â 1011 | Cancer remission; time to ICU admission less than 24Â h, poor performance status, Charlson comorbidity index, allogeneic HSCT, organ dysfunction score, cardiac arrest, acute respiratory failure, malignant organ infiltration, invasive aspergillosis | 47.9% required IMV, 51.2% required pressors | Â | Â | 60.7 | Â |
Townsend et al. (2013) | UK | Europe | Townsend | HM allo-HSCT NÂ =Â 213 | The need for ventilation | 50% required MV;45% required pressors | APACHE II: 23 | 68.0 | Â | Â |
Sawicka et al. (2014) | Poland | Europe | Sawicka | HM NÂ =Â 99 | SAPS II | Â | Â | 75.7 | Â | Â |
Khwankeaw and Bhurayanontachai (2014) | Thailand | Asia | Khwankeaw | HM NÂ =Â 145 | Mechanical ventilation, the use of vasopressors and the APACHE II scores | Â | Â | 55.2 | Â | Â |
Liu et al. (2015) | China | Asia | Liu and Cheng | HM N = 121 | The use of IMV, APACH II at admission, SOFA trend | 64.5% required IMV, 67.8% required pressors | APACHE II:20.84 ± 0.89 SOFA:10.75 ± 0.48 | 60.3 |  | 90.9 |