Skip to main content
SpringerPlus

Table 6 Subgroup analyses for IL-10 −1082A>G polymorphism and urologic cancer risk

From: Associations of IL-10 genetic polymorphisms with the risk of urologic cancer: a meta-analysis based on 18,415 subjects

Variables

P value

OR (95% Cl)

I-square (%)

P for the heterogeneity

Cancer type

Prostate cancer (No.a: 14)

 AA versus AG

0.84

0.98 (0.82–1.17)

65

0.0007

 AA versus GG

0.66

1.07 (0.80–1.42)

79

<0.0001

 AG versus GG

0.61

1.05 (0.87–1.27)

61

0.002

 AA versus AG+GG

0.90

0.99 (0.81–1.20)

75

<0.0001

 AG versus AA+GG

0.99

1.00 (0.93–1.08)

36

0.10

 GG versus AA+AG

0.53

0.94 (0.76–1.15)

71

<0.0001

 A versus G

0.78

1.02 (0.90–1.15)

79

<0.0001

Renal cancer (No.a: 4)

 AA versus AG

0.21

1.21 (0.90–1.62)

14

0.32

 AA versus GG

0.23

1.28 (0.85–1.92)

0

0.41

 AG versus GG

0.94

1.02 (0.68–1.51)

0

0.98

 AA versus AG+GG

0.17

1.21 (0.92–1.59)

34

0.21

 AG versus AA+GG

0.38

0.88 (0.67–1.16)

0

0.67

 GG versus AA+AG

0.49

0.88 (0.61–1.27)

0

0.78

 A versus G

0.17

1.15 (0.94–1.40)

29

0.24

Bladder cancer (No.a: 2)

 AA versus AG

0.42

1.37 (0.64–2.90)

83

0.01

 AA versus GG

0.02

2.00 (1.13–3.55)

0

0.96

 AG versus GG

0.01

2.03 (1.16–3.55)

0

0.59

 AA versus AG+GG

0.23

1.46 (0.79–2.70)

76

0.04

 AG versus AA+GG

0.62

0.79 (0.32–1.97)

89

0.003

 GG versus AA+AG

0.009

0.49 (0.28–0.84)

0

0.99

 A versus G

0.09

1.49 (0.94–2.38)

68

0.08

Ethnicity

Asian (No.a: 6)

 AA versus AG

0.70

0.93 (0.65–1.33)

68

0.007

 AA versus GG

0.90

0.95 (0.39–2.30)

76

0.0009

 AG versus GG

0.74

1.14 (0.53–2.48)

67

0.01

 AA versus AG+GG

0.76

0.94 (0.64–1.39)

76

0.0008

 AG versus AA+GG

0.60

1.09 (0.79–1.51)

64

0.02

 GG versus AA+AG

0.89

0.94 (0.42–2.12)

73

0.003

 A versus G

0.99

1.00 (0.69–1.44)

83

<0.0001

Caucasian (No.a: 9)

 AA versus AG

0.62

1.07 (0.81–1.41)

59

0.02

 AA versus GG

0.54

1.15 (0.73–1.82)

78

<0.0001

 AG versus GG

0.97

1.00 (0.84–1.19)

31

0.18

 AA versus AG+GG

0.59

1.09 (0.79–1.50)

73

0.0004

 AG versus AA+GG

0.49

0.95 (0.83–1.09)

0

0.67

 GG versus AA+AG

0.40

0.89 (0.67–1.17)

57

0.02

 A versus G

0.55

1.07 (0.85–1.34)

79

<0.0001

  1. The difference in cases and controls regarding the distributions of investigated genetic polymorphisms in certain genetic model reached the statistically significant level, which is also less than 0.05 are indicated in italics
  2. OR odds ratio, CI confidence interval
  3. aThe number of articles
Back to article page