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Table 5 Subgroup analyses for IL-10 −819C>T polymorphism and urologic cancer risk

From: Associations of IL-10 genetic polymorphisms with the risk of urologic cancer: a meta-analysis based on 18,415 subjects

Variables

P value

OR (95% Cl)

I-square (%)

P for the heterogeneity

Cancer type

Prostate cancer (No.a: 8)

 CC versus CT

0.22

1.10 (0.95–1.27)

46

0.07

 CC versus TT

0.18

1.11 (0.95–1.30)

27

0.22

 CT versus TT

0.79

0.98 (0.85–1.14)

0

0.68

 CC versus CT+TT

0.27

1.09 (0.94–1.27)

56

0.03

 CT versus CC+TT

0.16

0.94 (0.86–1.03)

32

0.17

 TT versus CC+CT

0.63

0.97 (0.84–1.11)

9

0.36

 C versus T

0.44

1.05 (0.93–1.17)

58

0.02

Renal cancer (No.a: 3)

 CC versus CT

0.75

1.07 (0.71–1.59)

40

0.19

 CC versus TT

0.77

0.85 (0.30–2.46)

60

0.08

 CT versus TT

0.15

0.74 (0.49–1.11)

26

0.26

 CC versus CT+TT

0.71

0.87 (0.42–1.80)

61

0.08

 CT versus CC+TT

0.13

0.78 (0.57–1.08)

12

0.32

 TT versus CC+CT

0.08

1.42 (0.96–2.09)

50

0.13

 C versus T

0.74

0.91 (0.52–1.60)

77

0.01

Bladder cancer (No.a: 2)

 CC versus CT

0.03

0.71 (0.52–0.96)

0

0.51

 CC versus TT

0.0005

0.57 (0.41–0.78)

0

0.45

 CT versus TT

0.29

0.79 (0.51–1.23)

68

0.08

 CC versus CT+TT

0.002

0.63 (0.47–0.84)

0

0.88

 CT versus CC+TT

0.85

0.95 (0.58–1.57)

80

0.02

 TT versus CC+CT

0.05

1.42 (1.01–2.00)

55

0.14

 C versus T

 <0.00001

0.72 (0.61–0.84)

21

0.26

Ethnicity

Asian (No.a: 6)

 CC versus CT

0.91

0.98 (0.72–1.35)

56

0.04

 CC versus TT

0.30

0.81 (0.55–1.21)

69

0.006

 CT versus TT

0.009

0.81 (0.69–0.95)

34

0.18

 CC versus CT+TT

0.54

0.89 (0.62–1.28)

70

0.005

 CT versus CC+TT

0.05

0.87 (0.75–1.00)

36

0.17

 TT versus CC+CT

0.09

1.23 (0.97–1.56)

60

0.03

 C versus T

0.21

0.87 (0.70–1.08)

77

0.0005

Caucasian (No.a: 4)

 CC versus CT

0.81

1.04 (0.74–1.48)

64

0.04

 CC versus TT

0.25

0.81 (0.57–1.16)

33

0.21

 CT versus TT

0.22

0.79 (0.55–1.15)

0

0.53

 CC versus CT+TT

0.89

1.03 (0.72–1.46)

68

0.02

 CT versus CC+TT

0.77

0.95 (0.69–1.31)

58

0.07

 TT versus CC+CT

0.33

1.22 (0.82–1.80)

13

0.33

 C versus T

0.97

1.01 (0.75–1.34)

68

0.02

  1. The difference in cases and controls regarding the distributions of investigated genetic polymorphisms in certain genetic model reached the statistically significant level, which is also less than 0.05 are indicated in italics
  2. OR odds ratio, CI confidence interval
  3. aThe number of articles
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