Associations of IL-10 genetic polymorphisms with the risk of urologic cancer: a meta-analysis based on 18,415 subjects

Shi, Xiaohan; Xie, Xiaochuan; Xun, Xiaoshuang; Jia, Yingxian; Li, Shangwei

doi:10.1186/s40064-016-3705-0

SpringerPlus

Table 4 Subgroup analyses for IL-10 −592C>A polymorphism and urologic cancer risk

From: Associations of IL-10 genetic polymorphisms with the risk of urologic cancer: a meta-analysis based on 18,415 subjects

Variables	P value	OR (95% Cl)	I-square (%)	P for the heterogeneity
Cancer type
Prostate cancer (No.^a: 10)
CC versus CA	0.99	1.00 (0.87–1.15)	49	0.05
CC versus AA	0.51	0.94 (0.80–1.12)	22	0.25
CA versus AA	0.37	0.93 (0.79–1.09)	0	0.85
CC versus CA+AA	0.85	0.99 (0.85–1.14)	56	0.02
CA versus CC+AA	0.97	1.00 (0.91–1.09)	36	0.13
AA versus CC+CA	0.47	1.06 (0.91–1.23)	0	0.54
C versus A	0.55	0.97 (0.89–1.07)	49	0.04
Renal cancer (No.^a: 3)
CC versus CA	0.35	1.21 (0.80–1.83)	0	0.50
CC versus AA	0.47	1.26 (0.67–2.36)	0	0.83
CA versus AA	0.94	0.99 (0.65–1.49)	0	0.50
CC versus CA+AA	0.30	1.23 (0.83–1.82)	0	0.66
CA versus CC+AA	0.40	0.87 (0.63–1.20)	0	0.39
AA versus CC+CA	0.98	1.00 (0.67–1.47)	0	0.56
C versus A	0.48	1.10 (0.85–1.41)	0	0.55
Bladder cancer (No.^a: 1)
CC versus CA	0.30	0.79 (0.50–1.23)	NA	NA
CC versus AA	0.002	0.51 (0.33–0.78)	NA	NA
CA versus AA	0.004	0.64 (0.48–0.87)	NA	NA
CC versus CA+AA	0.02	0.62 (0.41–0.93)	NA	NA
CA versus CC+AA	0.04	0.74 (0.56–0.99)	NA	NA
AA versus CC+CA	0.0004	1.65 (1.25–2.19)	NA	NA
C versus A	0.00001	0.66 (0.54–0.82)	NA	NA
Ethnicity
Asian (No.^a: 4)
CC versus CA	0.57	1.07 (0.84–1.37)	0	0.44
CC versus AA	0.70	0.91 (0.55–1.50)	68	0.03
CA versus AA	0.05	0.82 (0.68–1.00)	40	0.17
CC versus CA+AA	0.93	0.98 (0.66–1.46)	58	0.07
CA versus CC+AA	0.06	0.85 (0.71–1.01)	0	0.58
AA versus CC+CA	0.38	1.15 (0.84–1.58)	66	0.03
C versus A	0.61	0.93 (0.70–1.23)	78	0.003
Caucasian (No.^a: 7)
CC versus CA	0.89	0.99 (0.86–1.13)	52	0.06
CC versus AA	0.31	0.87 (0.66–1.14)	0	0.58
CA versus AA	0.37	0.88 (0.66–1.16)	0	0.75
CC versus CA+AA	0.84	0.98 (0.80–1.20)	53	0.06
CA versus CC+AA	1.00	1.00 (0.82–1.22)	49	0.08
AA versus CC+CA	0.30	1.15 (0.88–1.51)	0	0.70
C versus A	0.31	0.96 (0.88–1.04)	35	0.16

The difference in cases and controls regarding the distributions of investigated genetic polymorphisms in certain genetic model reached the statistically significant level, which is also less than 0.05 are indicated in italics
OR odds ratio, CI confidence interval, NA not applicable
^aThe number of articles

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