A concise drug alerting rule set for Chinese hospitals and its application in computerized physician order entry (CPOE)

Zhang, Yinsheng; Long, Xin; Chen, Weihong; Li, Haomin; Duan, Huilong; Shang, Qian

doi:10.1186/s40064-016-3701-4

SpringerPlus

Table 5 Drug rule set (Part 2: DDI pairs)

From: A concise drug alerting rule set for Chinese hospitals and its application in computerized physician order entry (CPOE)

Drug 1		Drug 2		Description
Vitamin C injection	维生素C注射液	Vitamin K1 injection	维生素K1注射液	Mixture prone to turbidity^a
Four-vitamin injection	复方维生素注射液(4)	Injection of fat-soluble vitamins I	注射脂溶性维生素我	Same ingredient. Duplicate therapy^a
Four-vitamin injection	复方维生素注射液(4)	Injection of fat-soluble vitamins II	注射脂溶性维生素II	Same ingredient. Duplicate therapy^a
Methylprednisolone sodium succinate for injection	甲泼尼龙琥珀酸钠注射液	Insulin injection	胰岛素注射	Methylprednisolone sodium succinate for injection increases requirements for insulin or oral hypoglycemic agents in diabetics^a
Methylprednisolone sodium succinate for injection	甲泼尼龙琥珀酸钠注射液	Recombinant human insulin injection	重组人胰岛素注射
Methylprednisolone sodium succinate for injection	甲泼尼龙琥珀酸钠注射液	Protamine recombinant human insulin injection	鱼精蛋白重组人胰岛素注射液
Salvia ligustrazine injection^b	丹参川芎嗪注射液^b	Vitamin K1 Injection	维生素K1注射液	Antagnistic effect^a
Ginkgo biloba extract injection	银杏叶提取物注射液^b	injection calf blood protein extract	注射用小牛血去蛋白提取物	Cause serious adverse effects, such as gastrointestinal discomfort, headache, decreased blood pressure, allergic reactions
Selegiline	司来吉兰	Pseudoephedrine	伪麻黄碱	MAO inhibitors—Amphetamine and derivatives
		Diethylpropion	二乙胺	MAO inhibitors—Amphetamine and derivatives
		Fluoxetine	氟西汀	MAO inhibitors— selective serotonin reuptake inhibitors (SSRIs)
		Paroxetine	帕罗西汀
		Citalopram	西酞普兰
		Escitalopram	艾司西酞普兰
		Sertraline	舍曲林
		Fluvoxamine	氟伏沙明
		Duloxetine	度洛西汀
		Venlafaxine	文拉法辛
		Meperidine	哌替啶	MAO inhibitors—narcotic analgesics
		Fentanyl	芬太尼
		Tramadol	曲马多
		Amitriptyline	阿米替林	Selegiline—tricyclic antidepressants (TCAs)
Irinotecan	伊立替康	Clarithromycin	克拉霉素	Irinotecan—strong CYP3A4 inhibitors
		Erythromycin	红霉素
		Amiodarone	胺碘酮
		Verapamil	维拉帕米
		Diltiazem	地尔硫卓
		Ketoconazole	酮康唑
		Itraconazole	伊曲康唑
		Fluconazole	氟康唑
		Voriconazole	伏立康唑
		Cimetidine	西咪替丁
Simvastatin	辛伐他汀	Clarithromycin	克拉霉素	HMG Co-A reductase inhibitors—CYP3A4 inhibitors
		Erythromycin	红霉素
		Amiodarone	胺碘酮
		Verapamil	维拉帕米
		Diltiazem	地尔硫卓
		Ketoconazole	酮康唑
		Itraconazole	伊曲康唑
		Fluconazole	氟康唑
		Voriconazole	伏立康唑
		Roxithromycin	罗红霉素	Severe DDI reported from literature, including rhabdomyolysis and liver damage
Ergotamine	麦角胺	Clarithromycin	克拉霉素	Ergot alkaloids and derivatives—CYP3A4 inhibitors
		Erythromycin	红霉素
		Ketoconazole	酮康唑
		Itraconazole	伊曲康唑
		Voreconazole	伏立康唑
Tizanidine	替扎尼定	Ciprofloxacin	环丙沙星	Tizanidine—CYP1A2 inhibitors
		Fluvoxamine	氟伏沙明
		Mexiletine	美西律
		Propafenone	普罗帕酮
		Amiodarone	胺碘酮
Zolmitriptan	佐米曲普坦	Moclobamide	吗氯贝胺	Triptans—MAO inhibitors
Zolmitriptan	佐米曲普坦	Methylene blue	亚甲蓝	Triptans—MAO inhibitors
Chloroquine	氯喹	QT prolonging agents. Any of two drugs have synergistic effect
Moxifloxacin	莫西沙星
Sotalol	索他洛尔
Clarithromycin	克拉霉素
Citalopram	西酞普兰
Amiodarone	胺碘酮
Erythromycin	红霉素
Haloperidol	氟哌啶醇
Droperidol	氟哌利多
Domperidone	多潘立酮
Procainamide	普鲁卡因胺
Sevoflurane	七氟醚
Chlorpromazine	氯丙嗪
Arsenic trioxide	白砒
Azithromycin	阿奇霉素

^aMeans these rules are added by the local pharmacists; others are from the work published by other researchers (Phansalkar et al. 2012)
^bChinese patent medicine

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