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Table 3 Distribution of IL28B rs12979860 genotype by region of enrolment and HCV RNA genotype

From: IL28B genotype is associated with cirrhosis or transition to cirrhosis in treatment-naive patients with chronic HCV genotype 1 infection: the international observational Gen-C study

HCV genotype IL28B rs12979860 genotype p valuea
CC CT TT
G1 (n = 1702)     
 Asia (n = 25) 16 (64.0) 9 (36.0) 0 (0.0)  
 Europe (n = 1251) 388 (31.0) 680 (54.4) 183 (14.6)  
 Middle East (n = 289) 65 (22.5) 167 (57.8) 57 (19.7)  
 Latin America (n = 137) 31 (22.6) 74 (54.0) 32 (23.4)  
 Total (n = 1702) 500 (29.4) 930 (54.6) 272 (16.0) <0.0001
G2 (n = 323)     
 Asia (n = 6) 4 (66.7) 2 (33.3) 0 (0.0)  
 Europe (n = 291) 111 (38.1) 144 (49.5) 36 (12.4)  
 Middle East (n = 19) 7 (36.8) 12 (63.2) 0 (0.0)  
 Latin America (n = 7) 4 (57.1) 2 (28.6) 1 (14.3)  
 Total (n = 323) 126 (39.0) 160 (49.5) 37 (11.5) 0.3572
G3 (n = 574)     
 Asia (n = 105) 45 (42.9) 52 (49.5) 8 (7.6)  
 Europe (n = 432) 177 (41.0) 200 (46.3) 55 (12.7)  
 Middle East (n = 30) 8 (26.7) 20 (66.7) 2 (6.7)  
 Latin America (n = 7) 2 (28.6) 5 (71.4) 0 (0.0)  
 Total (n = 574) 232 (40.4) 277 (48.3) 65 (11.3) 0.2041
G4 (n = 260)     
 Asia (n = 0) 0 0 0  
 Europe (n = 128) 37 (28.9) 64 (50.0) 27 (21.1)  
 Middle East (n = 127) 53 (41.7) 62 (48.8) 12 (9.4)  
 Latin America (n = 5) 2 (40.0) 3 (60.0) 0 (0.0)  
 Total (n = 260) 92 (35.4) 129 (49.6) 39 (15.0) 0.0467
  1. aPearson’s Chi square test for differences in IL28B rs12979860 genotype by variables