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Table 2 Association between liver fibrosis and IL28B rs12979860 genotype in patients with HCV G1 infection, by region of enrolment

From: IL28B genotype is associated with cirrhosis or transition to cirrhosis in treatment-naive patients with chronic HCV genotype 1 infection: the international observational Gen-C study

Patients, n (%) IL28B rs12979860 genotype
CC TC TT p valuea
Asia (n = 25)     
 Cirrhosis/transition to cirrhosis 8 (50.0) 5 (55.6) ND  
 No cirrhosis 8 (50.0) 4 (52.3) ND 0.7896
European (n = 1245)     
 Cirrhosis/transition to cirrhosis 78 (20.2) 168 (24.8) 57 (31.7)  
 No cirrhosis 309 (79.8) 510 (75.2) 123 (68.3) 0.0030
Latin America (n = 137)     
 Cirrhosis/transition to cirrhosis 9 (29.0) 25 (33.8) 10 (31.3)  
 No cirrhosis 22 (71.0) 49 (66.2) 22 (68.8) 0.8547
Middle East (n = 289)     
 Cirrhosis/transition to cirrhosis 16 (24.6) 57 (34.1) 20 (35.1)  
 No cirrhosis 49 (75.4) 110 (65.9) 37 (64.9) 0.2022
  1. ND no data available
  2. aCochran-Armitage trend test for a trend in binomial proportions across the three IL28B genotype categories