Genetic model | Subgroups | No. of studies | Heterogeneity | Test of association | ||||
---|---|---|---|---|---|---|---|---|
Model | P value | I 2 (%) | OR | 95% CI | P value | |||
T versus C | Overall | 10 | R | <0.001 | 88.0 | 1.86 | 1.19–2.92 | 0.007 |
HWE (yes) | 9 | R | <0.001 | 87.1 | 2.07 | 1.32–3.26 | 0.002 | |
Asian | 9 | R | <0.001 | 87.1 | 2.07 | 1.32–3.26 | 0.002 | |
Caucasian | 1 | R | – | – | 0.07 | 0.40–1.22 | 0.21 | |
TT versus CC | Overall | 10 | R | <0.001 | 71.9 | 2.41 | 0.96–6.06 | 0.06 |
HWE (yes) | 9 | R | 0.004 | 64.7 | 2.97 | 1.14–7.75 | 0.03 | |
Asian | 9 | R | 0.004 | 64.7 | 2.97 | 1.14–7.75 | 0.03 | |
Caucasian | 1 | R | – | – | 0.69 | 0.30–1.56 | 0.37 | |
CT versus CC | Overall | 10 | R | <0.001 | 84.0 | 2.51 | 1.49–4.23 | 0.001 |
HWE (yes) | 9 | R | <0.001 | 85.1 | 2.72 | 1.59–4.66 | <0.001 | |
Asian | 9 | R | <0.001 | 85.1 | 2.72 | 1.59–4.66 | <0.001 | |
Caucasian | 1 | R | – | – | 0.73 | 0.16–3.2 | 0.68 | |
TT + CT versus CC | Overall | 10 | R | <0.001 | 87.9 | 2.46 | 1.40–4.30 | 0.002 |
HWE (yes) | 9 | R | <0.001 | 87.5 | 2.80 | 1.59–4.96 | <0.001 | |
Asian | 9 | R | <0.001 | 87.5 | 2.80 | 1.59–4.96 | <0.001 | |
Caucasian | 1 | R | – | – | 0.69 | 0.32–1.49 | 0.35 | |
TT versus CC + CT | Overall | 10 | R | 0.005 | 62.1 | 1.54 | 0.71–3.35 | 0.28 |
HWE (yes) | 9 | R | 0.011 | 59.8 | 1.77 | 0.74–4.25 | 0.20 | |
Asian | 9 | R | 0.011 | 59.8 | 1.77 | 0.74–4.25 | 0.20 | |
Caucasian | 1 | R | – | – | 0.71 | 0.31–1.59 | 0.40 |