Test | References | Cutoff value | N | TP | FP | FN | TN | AUC | Sensitivity | Specificity |
---|---|---|---|---|---|---|---|---|---|---|
Acute phase protein | ||||||||||
AGP | Xiao et al. (2015) | 1462Â mg/l | 277 | 150 | 8 | 42 | 77 | 0.869 | 0.782 | 0.902 |
MBL | Ruiz-Alvarez et al. (2009) | – | 104 | 49 | 13 | 29 | 13 | 0.6 | 0.63 | 0.5 |
SAA | Reichsoellner et al. (2014) | 289.4 μg/ml | 159 | 80 | 32 | 30 | 17 | 0.519 | 0.73 | 0.35 |
sPLA2-IIA | Tan et al. (2016) | 2.13 μg/l | 51 | 38 | 2 | 4 | 7 | – | 0.91 | 0.78 |
Biomarkers related to vaosdilation | ||||||||||
Substance P | Reichsoellner et al. (2014) | 0.3Â ng/ml | 159 | 62 | 23 | 48 | 26 | 0.524 | 0.56 | 0.53 |
Cell marker biomarkers | ||||||||||
CD64/CD16 | Hsu et al. (2011) | – | 66 | 47 | 2 | 8 | 9 | 0.883 | 0.855 | 0.818 |
CD11C | Lewis et al. (2015) | 48.50% | 103 | 67 | 4 | 16 | 16 | 0.89 | 0.807 | 0.8 |
sCD22 | Jiang et al. (2015) | 2.3 ng/ml | 64 | 31 | 6 | 7 | 20 | – | 0.8158 | 0.7692 |
sCD163 | Feng et al. (2012) | 1.49 μg/ml | 132 | 75 | 2 | 27 | 28 | 0.856 | 0.74 | 0.9333 |
sCD25 | Matera et al. (2013) | – | 53 | 25 | 6 | 4 | 18 | 0.812 | 0.875 | 0.75 |
Coagulation biomarkers | ||||||||||
protein C activity | Ishikura et al. (2014) | 47% | 82 | 33 | 7 | 10 | 32 | – | 0.775 | 0.811 |
Thrombomodulin | Reichsoellner et al. (2014) | 0Â ng/ml | 159 | 30 | 9 | 80 | 40 | 0.543 | 0.27 | 0.81 |
Cytokine/chemokine biomarkers | ||||||||||
IFN-r | Jekarl et al. (2014) | 45Â pg/ml | 127 | 68 | 16 | 29 | 14 | 0.573 | 0.702 | 0.464 |
IFN-r | Matera et al. (2013) | 9Â pg/ml | 52 | 13 | 7 | 15 | 17 | 0.486 | 0.4545 | 0.7 |
IL-1 | Jekarl et al. (2014) | 30Â pg/ml | 128 | 38 | 8 | 59 | 23 | 0.554 | 0.394 | 0.75 |
IL-10 | Jekarl et al. (2014) | 40Â pg/ml | 127 | 32 | 1 | 65 | 29 | 0.661 | 0.329 | 0.964 |
IL-10 | Matera et al. (2013) | 3.05Â pg/ml | 52 | 22 | 5 | 6 | 19 | 0.767 | 0.7826 | 0.8 |
IL-10 | Reichsoellner et al. (2014) | 1.9Â ng/ml | 159 | 25 | 16 | 85 | 33 | 0.508 | 0.23 | 0.67 |
IL-12 | Jekarl et al. (2014) | 2Â pg/ml | 127 | 18 | 9 | 79 | 21 | 0.504 | 0.181 | 0.714 |
IL-13 | Jekarl et al. (2014) | 40Â pg/ml | 128 | 85 | 23 | 12 | 8 | 0.508 | 0.872 | 0.25 |
IL-17 | Jekarl et al. (2014) | 1.5Â pg/ml | 127 | 41 | 9 | 56 | 21 | 0.586 | 0.426 | 0.714 |
IL-2 | Jekarl et al. (2014) | 35Â pg/ml | 127 | 87 | 24 | 10 | 6 | 0.534 | 0.894 | 0.214 |
IL-2 | Balc et al. (2003) | 1288.5Â pg/ml | 83 | 22 | 22 | 13 | 26 | 0.641 | 0.63 | 0.55 |
IL22 | Jekarl et al. (2014) | 300Â pg/ml | 127 | 75 | 18 | 22 | 12 | 0.542 | 0.776 | 0.393 |
IL-4 | Jekarl et al. (2014) | 25Â pg/ml | 127 | 85 | 24 | 12 | 6 | 0.516 | 0.872 | 0.214 |
IL-5 | Jekarl et al. (2014) | 5Â pg/ml | 127 | 69 | 9 | 28 | 21 | 0.714 | 0.713 | 0.714 |
IL-8 | Balc et al. (2003) | 31.5Â pg/ml | 83 | 24 | 21 | 11 | 27 | 0.663 | 0.68 | 0.57 |
IL-8 | Harbarth et al. (2001) | 30Â ng/ml | 78 | 38 | 4 | 22 | 14 | 0.71 | 0.63 | 0.78 |
IL-8 | Reichsoellner et al. (2014) | 507.2Â pg/ml | 160 | 50 | 11 | 61 | 38 | 0.625 | 0.45 | 0.77 |
IL-9 | Jekarl et al. (2014) | 5Â pg/ml | 128 | 83 | 23 | 14 | 8 | 0.532 | 0.851 | 0.25 |
MIF | Kofoed et al. (2007) | 0.81Â ng/ml | 151 | 77 | 29 | 19 | 26 | 0.63 | 0.8 | 0.47 |
Osteopontin | Vaschetto et al. (2008) | 1.7Â ng/ml | 56 | 19 | 6 | 8 | 23 | 0.796 | 0.7 | 0.79 |
TNF-α | Balc et al. (2003) | 11.5 pg/ml | 83 | 19 | 16 | 16 | 32 | 0.607 | 0.55 | 0.66 |
TNF-α | Jekarl et al. (2014) | 15 pg/ml | 128 | 47 | 8 | 50 | 23 | 0.598 | 0.489 | 0.75 |
TNF-α | 9.75 pg/ml | 52 | 26 | 4 | 12 | 10 | 0.796 | 0.68 | 0.71 | |
Receptor biomarkers | ||||||||||
DcR3 | Hou et al. (2012) | 2.85Â ng/ml | 67 | 23 | 14 | 1 | 29 | 0.896 | 0.958 | 0.674 |
DcR3 | Kim et al. (2012) | 3.24Â ng/ml | 48 | 24 | 4 | 1 | 19 | 0.958 | 0.96 | 0.826 |
PLA2-II | Mearelli et al. (2014) | 6Â ng/ml | 80 | 58 | 8 | 2 | 12 | 0.851 | 0.97 | 0.6 |
suPAR | Hoenigl et al. (2013) | 7.9Â ng/ml | 132 | 34 | 18 | 21 | 59 | 0.726 | 0.62 | 0.77 |
suPAR | Kofoed et al. (2007) | 2.7Â ng/ml | 151 | 34 | 18 | 62 | 37 | 0.5 | 0.35 | 0.67 |
suPAR | Reichsoellner et al. (2014) | 7.6Â ng/ml | 160 | 61 | 7 | 50 | 42 | 0.66 | 0.55 | 0.86 |
Vascular endothelial biomarkers | ||||||||||
Endocan | Scherpereel et al. (2006) | 1.2Â ng/ml | 70 | 52 | 0 | 11 | 7 | 0.923 | 0.825 | 1 |
sICAM-1 | de Pablo et al. (2013) | 904Â ng/ml | 92 | 39 | 2 | 13 | 38 | 0.9 | 0.743 | 0.941 |
Other biomarkers | ||||||||||
Ang 2 | Mearelli et al. (2014) | 3.2Â ng/ml | 80 | 49 | 12 | 11 | 8 | 0.581 | 0.82 | 0.4 |
Biotin | Reichsoellner et al. (2014) | 70.4Â pg/ml | 159 | 55 | 9 | 55 | 40 | 0.646 | 0.5 | 0.81 |
C2 | Ruiz-Alvarez et al. (2009) | – | 104 | 6 | 3 | 72 | 23 | 0.5 | 0.08 | 0.9 |
C3 | Sungurtekin et al. (2006) | 54Â mg/dL | 99 | 25 | 22 | 16 | 36 | 0.566 | 0.61 | 0.625 |
C3a | Selberg et al. (2000) | 540Â ng/ml | 33 | 19 | 2 | 3 | 9 | 0.9 | 0.86 | 0.8 |
C4 | Sungurtekin et al. (2006) | 28Â mg/dL | 99 | 32 | 36 | 9 | 22 | 0.544 | 0.78 | 0.382 |
cf-DNA | Garnacho-Montero et al. (2014) | 2850GE/ml | 81 | 41 | 20 | 11 | 9 | 0.51 | 0.7931 | 0.3023 |
cf-DNA | Hou et al. (2016) | 493Â pg/ml | 67 | 23 | 13 | 1 | 30 | 0.856 | 0.9412 | 0.7059 |
Copeptin | Battista et al. (2016) | 23.2 pmol/l | 90 | 47 | 3 | 17 | 23 | – | 0.74 | 0.87 |
Cystatin C | Reichsoellner et al. (2014) | 2.1 μg/ml | 159 | 55 | 14 | 55 | 35 | 0.578 | 0.5 | 0.71 |
Delta neutrophil index | Seok et al. (2012) | 0.03% | 174 | 93 | 1 | 34 | 46 | 0.88 | – | – |
Elastase | Selberg et al. (2000) | 91 μg/ml | 33 | 19 | 10 | 3 | 1 | 0.57 | 0.86 | 0.09 |
eosinophil | Abidi et al. (2008) | – | 140 | 96 | 4 | 24 | 16 | 0.84 | 0.8 | 0.8 |
Fibronectin | Reichsoellner et al. (2014) | 377.4 μg/ml | 159 | 59 | 15 | 51 | 34 | 0.384 | 0.54 | 0.69 |
Interferon-induced protein 10 | Mearelli et al. (2014) | 19.5Â ng/ml | 80 | 16 | 0 | 44 | 20 | 0.666 | 0.27 | 1 |
leptin | Farag et al. (2013) | 38.05 ng/ml | 30 | 14 | 0 | 1 | 15 | – |  |  |
Leptin | Yousef et al. (2010) | 38 ng/ml | 74 | 36 | 5 | 4 | 29 | – | 0.912 | 0.85 |
miR-143 | Han et al. (2016) | 15.9 ng/ml | 198 | 81 | 8 | 22 | 87 | – | 0.786 | 0.916 |
miR-146a | Wang et al. (2013) | – | 18 | 6 | 1 | 4 | 7 | 0.813 | 0.6 | 0.875 |
miR-15a | Wang et al. (2012) | – | 198 | 113 | 2 | 53 | 30 | 0.858 | 0.683 | 0.944 |
NGAL | Reichsoellner et al. (2014) | 82Â ng/ml | 159 | 29 | 2 | 81 | 47 | 0.599 | 0.26 | 0.96 |
Peroxiredoxin4 | Schulte et al. (2011) | 4.5 U/l | 79 | 32 | 7 | 11 | 29 | 0.824 | – | – |
Thrombocytes | Sungurtekin et al. (2006) | – | 99 | 27 | 17 | 14 | 41 | 0.656 | 0.659 | 0.707 |