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Table 2 The research results for the biomarkers with less than 4 references

From: Biomarkers for diagnosis of sepsis in patients with systemic inflammatory response syndrome: a systematic review and meta-analysis

Test

References

Cutoff value

N

TP

FP

FN

TN

AUC

Sensitivity

Specificity

Acute phase protein

AGP

Xiao et al. (2015)

1462 mg/l

277

150

8

42

77

0.869

0.782

0.902

MBL

Ruiz-Alvarez et al. (2009)

–

104

49

13

29

13

0.6

0.63

0.5

SAA

Reichsoellner et al. (2014)

289.4 μg/ml

159

80

32

30

17

0.519

0.73

0.35

sPLA2-IIA

Tan et al. (2016)

2.13 μg/l

51

38

2

4

7

–

0.91

0.78

Biomarkers related to vaosdilation

Substance P

Reichsoellner et al. (2014)

0.3 ng/ml

159

62

23

48

26

0.524

0.56

0.53

Cell marker biomarkers

CD64/CD16

Hsu et al. (2011)

–

66

47

2

8

9

0.883

0.855

0.818

CD11C

Lewis et al. (2015)

48.50%

103

67

4

16

16

0.89

0.807

0.8

sCD22

Jiang et al. (2015)

2.3 ng/ml

64

31

6

7

20

–

0.8158

0.7692

sCD163

Feng et al. (2012)

1.49 μg/ml

132

75

2

27

28

0.856

0.74

0.9333

sCD25

Matera et al. (2013)

–

53

25

6

4

18

0.812

0.875

0.75

Coagulation biomarkers

protein C activity

Ishikura et al. (2014)

47%

82

33

7

10

32

–

0.775

0.811

Thrombomodulin

Reichsoellner et al. (2014)

0 ng/ml

159

30

9

80

40

0.543

0.27

0.81

Cytokine/chemokine biomarkers

IFN-r

Jekarl et al. (2014)

45 pg/ml

127

68

16

29

14

0.573

0.702

0.464

IFN-r

Matera et al. (2013)

9 pg/ml

52

13

7

15

17

0.486

0.4545

0.7

IL-1

Jekarl et al. (2014)

30 pg/ml

128

38

8

59

23

0.554

0.394

0.75

IL-10

Jekarl et al. (2014)

40 pg/ml

127

32

1

65

29

0.661

0.329

0.964

IL-10

Matera et al. (2013)

3.05 pg/ml

52

22

5

6

19

0.767

0.7826

0.8

IL-10

Reichsoellner et al. (2014)

1.9 ng/ml

159

25

16

85

33

0.508

0.23

0.67

IL-12

Jekarl et al. (2014)

2 pg/ml

127

18

9

79

21

0.504

0.181

0.714

IL-13

Jekarl et al. (2014)

40 pg/ml

128

85

23

12

8

0.508

0.872

0.25

IL-17

Jekarl et al. (2014)

1.5 pg/ml

127

41

9

56

21

0.586

0.426

0.714

IL-2

Jekarl et al. (2014)

35 pg/ml

127

87

24

10

6

0.534

0.894

0.214

IL-2

Balc et al. (2003)

1288.5 pg/ml

83

22

22

13

26

0.641

0.63

0.55

IL22

Jekarl et al. (2014)

300 pg/ml

127

75

18

22

12

0.542

0.776

0.393

IL-4

Jekarl et al. (2014)

25 pg/ml

127

85

24

12

6

0.516

0.872

0.214

IL-5

Jekarl et al. (2014)

5 pg/ml

127

69

9

28

21

0.714

0.713

0.714

IL-8

Balc et al. (2003)

31.5 pg/ml

83

24

21

11

27

0.663

0.68

0.57

IL-8

Harbarth et al. (2001)

30 ng/ml

78

38

4

22

14

0.71

0.63

0.78

IL-8

Reichsoellner et al. (2014)

507.2 pg/ml

160

50

11

61

38

0.625

0.45

0.77

IL-9

Jekarl et al. (2014)

5 pg/ml

128

83

23

14

8

0.532

0.851

0.25

MIF

Kofoed et al. (2007)

0.81 ng/ml

151

77

29

19

26

0.63

0.8

0.47

Osteopontin

Vaschetto et al. (2008)

1.7 ng/ml

56

19

6

8

23

0.796

0.7

0.79

TNF-α

Balc et al. (2003)

11.5 pg/ml

83

19

16

16

32

0.607

0.55

0.66

TNF-α

Jekarl et al. (2014)

15 pg/ml

128

47

8

50

23

0.598

0.489

0.75

TNF-α

Li et al. (2013a, b)

9.75 pg/ml

52

26

4

12

10

0.796

0.68

0.71

Receptor biomarkers

DcR3

Hou et al. (2012)

2.85 ng/ml

67

23

14

1

29

0.896

0.958

0.674

DcR3

Kim et al. (2012)

3.24 ng/ml

48

24

4

1

19

0.958

0.96

0.826

PLA2-II

Mearelli et al. (2014)

6 ng/ml

80

58

8

2

12

0.851

0.97

0.6

suPAR

Hoenigl et al. (2013)

7.9 ng/ml

132

34

18

21

59

0.726

0.62

0.77

suPAR

Kofoed et al. (2007)

2.7 ng/ml

151

34

18

62

37

0.5

0.35

0.67

suPAR

Reichsoellner et al. (2014)

7.6 ng/ml

160

61

7

50

42

0.66

0.55

0.86

Vascular endothelial biomarkers

Endocan

Scherpereel et al. (2006)

1.2 ng/ml

70

52

0

11

7

0.923

0.825

1

sICAM-1

de Pablo et al. (2013)

904 ng/ml

92

39

2

13

38

0.9

0.743

0.941

Other biomarkers

Ang 2

Mearelli et al. (2014)

3.2 ng/ml

80

49

12

11

8

0.581

0.82

0.4

Biotin

Reichsoellner et al. (2014)

70.4 pg/ml

159

55

9

55

40

0.646

0.5

0.81

C2

Ruiz-Alvarez et al. (2009)

–

104

6

3

72

23

0.5

0.08

0.9

C3

Sungurtekin et al. (2006)

54 mg/dL

99

25

22

16

36

0.566

0.61

0.625

C3a

Selberg et al. (2000)

540 ng/ml

33

19

2

3

9

0.9

0.86

0.8

C4

Sungurtekin et al. (2006)

28 mg/dL

99

32

36

9

22

0.544

0.78

0.382

cf-DNA

Garnacho-Montero et al. (2014)

2850GE/ml

81

41

20

11

9

0.51

0.7931

0.3023

cf-DNA

Hou et al. (2016)

493 pg/ml

67

23

13

1

30

0.856

0.9412

0.7059

Copeptin

Battista et al. (2016)

23.2 pmol/l

90

47

3

17

23

–

0.74

0.87

Cystatin C

Reichsoellner et al. (2014)

2.1 μg/ml

159

55

14

55

35

0.578

0.5

0.71

Delta neutrophil index

Seok et al. (2012)

0.03%

174

93

1

34

46

0.88

–

–

Elastase

Selberg et al. (2000)

91 μg/ml

33

19

10

3

1

0.57

0.86

0.09

eosinophil

Abidi et al. (2008)

–

140

96

4

24

16

0.84

0.8

0.8

Fibronectin

Reichsoellner et al. (2014)

377.4 μg/ml

159

59

15

51

34

0.384

0.54

0.69

Interferon-induced protein 10

Mearelli et al. (2014)

19.5 ng/ml

80

16

0

44

20

0.666

0.27

1

leptin

Farag et al. (2013)

38.05 ng/ml

30

14

0

1

15

–

  

Leptin

Yousef et al. (2010)

38 ng/ml

74

36

5

4

29

–

0.912

0.85

miR-143

Han et al. (2016)

15.9 ng/ml

198

81

8

22

87

–

0.786

0.916

miR-146a

Wang et al. (2013)

–

18

6

1

4

7

0.813

0.6

0.875

miR-15a

Wang et al. (2012)

–

198

113

2

53

30

0.858

0.683

0.944

NGAL

Reichsoellner et al. (2014)

82 ng/ml

159

29

2

81

47

0.599

0.26

0.96

Peroxiredoxin4

Schulte et al. (2011)

4.5 U/l

79

32

7

11

29

0.824

–

–

Thrombocytes

Sungurtekin et al. (2006)

–

99

27

17

14

41

0.656

0.659

0.707