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Table 2 The research results for the biomarkers with less than 4 references

From: Biomarkers for diagnosis of sepsis in patients with systemic inflammatory response syndrome: a systematic review and meta-analysis

Test References Cutoff value N TP FP FN TN AUC Sensitivity Specificity
Acute phase protein
AGP Xiao et al. (2015) 1462 mg/l 277 150 8 42 77 0.869 0.782 0.902
MBL Ruiz-Alvarez et al. (2009) 104 49 13 29 13 0.6 0.63 0.5
SAA Reichsoellner et al. (2014) 289.4 μg/ml 159 80 32 30 17 0.519 0.73 0.35
sPLA2-IIA Tan et al. (2016) 2.13 μg/l 51 38 2 4 7 0.91 0.78
Biomarkers related to vaosdilation
Substance P Reichsoellner et al. (2014) 0.3 ng/ml 159 62 23 48 26 0.524 0.56 0.53
Cell marker biomarkers
CD64/CD16 Hsu et al. (2011) 66 47 2 8 9 0.883 0.855 0.818
CD11C Lewis et al. (2015) 48.50% 103 67 4 16 16 0.89 0.807 0.8
sCD22 Jiang et al. (2015) 2.3 ng/ml 64 31 6 7 20 0.8158 0.7692
sCD163 Feng et al. (2012) 1.49 μg/ml 132 75 2 27 28 0.856 0.74 0.9333
sCD25 Matera et al. (2013) 53 25 6 4 18 0.812 0.875 0.75
Coagulation biomarkers
protein C activity Ishikura et al. (2014) 47% 82 33 7 10 32 0.775 0.811
Thrombomodulin Reichsoellner et al. (2014) 0 ng/ml 159 30 9 80 40 0.543 0.27 0.81
Cytokine/chemokine biomarkers
IFN-r Jekarl et al. (2014) 45 pg/ml 127 68 16 29 14 0.573 0.702 0.464
IFN-r Matera et al. (2013) 9 pg/ml 52 13 7 15 17 0.486 0.4545 0.7
IL-1 Jekarl et al. (2014) 30 pg/ml 128 38 8 59 23 0.554 0.394 0.75
IL-10 Jekarl et al. (2014) 40 pg/ml 127 32 1 65 29 0.661 0.329 0.964
IL-10 Matera et al. (2013) 3.05 pg/ml 52 22 5 6 19 0.767 0.7826 0.8
IL-10 Reichsoellner et al. (2014) 1.9 ng/ml 159 25 16 85 33 0.508 0.23 0.67
IL-12 Jekarl et al. (2014) 2 pg/ml 127 18 9 79 21 0.504 0.181 0.714
IL-13 Jekarl et al. (2014) 40 pg/ml 128 85 23 12 8 0.508 0.872 0.25
IL-17 Jekarl et al. (2014) 1.5 pg/ml 127 41 9 56 21 0.586 0.426 0.714
IL-2 Jekarl et al. (2014) 35 pg/ml 127 87 24 10 6 0.534 0.894 0.214
IL-2 Balc et al. (2003) 1288.5 pg/ml 83 22 22 13 26 0.641 0.63 0.55
IL22 Jekarl et al. (2014) 300 pg/ml 127 75 18 22 12 0.542 0.776 0.393
IL-4 Jekarl et al. (2014) 25 pg/ml 127 85 24 12 6 0.516 0.872 0.214
IL-5 Jekarl et al. (2014) 5 pg/ml 127 69 9 28 21 0.714 0.713 0.714
IL-8 Balc et al. (2003) 31.5 pg/ml 83 24 21 11 27 0.663 0.68 0.57
IL-8 Harbarth et al. (2001) 30 ng/ml 78 38 4 22 14 0.71 0.63 0.78
IL-8 Reichsoellner et al. (2014) 507.2 pg/ml 160 50 11 61 38 0.625 0.45 0.77
IL-9 Jekarl et al. (2014) 5 pg/ml 128 83 23 14 8 0.532 0.851 0.25
MIF Kofoed et al. (2007) 0.81 ng/ml 151 77 29 19 26 0.63 0.8 0.47
Osteopontin Vaschetto et al. (2008) 1.7 ng/ml 56 19 6 8 23 0.796 0.7 0.79
TNF-α Balc et al. (2003) 11.5 pg/ml 83 19 16 16 32 0.607 0.55 0.66
TNF-α Jekarl et al. (2014) 15 pg/ml 128 47 8 50 23 0.598 0.489 0.75
TNF-α Li et al. (2013a, b) 9.75 pg/ml 52 26 4 12 10 0.796 0.68 0.71
Receptor biomarkers
DcR3 Hou et al. (2012) 2.85 ng/ml 67 23 14 1 29 0.896 0.958 0.674
DcR3 Kim et al. (2012) 3.24 ng/ml 48 24 4 1 19 0.958 0.96 0.826
PLA2-II Mearelli et al. (2014) 6 ng/ml 80 58 8 2 12 0.851 0.97 0.6
suPAR Hoenigl et al. (2013) 7.9 ng/ml 132 34 18 21 59 0.726 0.62 0.77
suPAR Kofoed et al. (2007) 2.7 ng/ml 151 34 18 62 37 0.5 0.35 0.67
suPAR Reichsoellner et al. (2014) 7.6 ng/ml 160 61 7 50 42 0.66 0.55 0.86
Vascular endothelial biomarkers
Endocan Scherpereel et al. (2006) 1.2 ng/ml 70 52 0 11 7 0.923 0.825 1
sICAM-1 de Pablo et al. (2013) 904 ng/ml 92 39 2 13 38 0.9 0.743 0.941
Other biomarkers
Ang 2 Mearelli et al. (2014) 3.2 ng/ml 80 49 12 11 8 0.581 0.82 0.4
Biotin Reichsoellner et al. (2014) 70.4 pg/ml 159 55 9 55 40 0.646 0.5 0.81
C2 Ruiz-Alvarez et al. (2009) 104 6 3 72 23 0.5 0.08 0.9
C3 Sungurtekin et al. (2006) 54 mg/dL 99 25 22 16 36 0.566 0.61 0.625
C3a Selberg et al. (2000) 540 ng/ml 33 19 2 3 9 0.9 0.86 0.8
C4 Sungurtekin et al. (2006) 28 mg/dL 99 32 36 9 22 0.544 0.78 0.382
cf-DNA Garnacho-Montero et al. (2014) 2850GE/ml 81 41 20 11 9 0.51 0.7931 0.3023
cf-DNA Hou et al. (2016) 493 pg/ml 67 23 13 1 30 0.856 0.9412 0.7059
Copeptin Battista et al. (2016) 23.2 pmol/l 90 47 3 17 23 0.74 0.87
Cystatin C Reichsoellner et al. (2014) 2.1 μg/ml 159 55 14 55 35 0.578 0.5 0.71
Delta neutrophil index Seok et al. (2012) 0.03% 174 93 1 34 46 0.88
Elastase Selberg et al. (2000) 91 μg/ml 33 19 10 3 1 0.57 0.86 0.09
eosinophil Abidi et al. (2008) 140 96 4 24 16 0.84 0.8 0.8
Fibronectin Reichsoellner et al. (2014) 377.4 μg/ml 159 59 15 51 34 0.384 0.54 0.69
Interferon-induced protein 10 Mearelli et al. (2014) 19.5 ng/ml 80 16 0 44 20 0.666 0.27 1
leptin Farag et al. (2013) 38.05 ng/ml 30 14 0 1 15   
Leptin Yousef et al. (2010) 38 ng/ml 74 36 5 4 29 0.912 0.85
miR-143 Han et al. (2016) 15.9 ng/ml 198 81 8 22 87 0.786 0.916
miR-146a Wang et al. (2013) 18 6 1 4 7 0.813 0.6 0.875
miR-15a Wang et al. (2012) 198 113 2 53 30 0.858 0.683 0.944
NGAL Reichsoellner et al. (2014) 82 ng/ml 159 29 2 81 47 0.599 0.26 0.96
Peroxiredoxin4 Schulte et al. (2011) 4.5 U/l 79 32 7 11 29 0.824
Thrombocytes Sungurtekin et al. (2006) 99 27 17 14 41 0.656 0.659 0.707