Biomarkers for diagnosis of sepsis in patients with systemic inflammatory response syndrome: a systematic review and meta-analysis

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Table 1 Research results of biomarkers with at least 4 references

Test	Studies	Cut-off	n	TP	FP	FN	TN	AUC (95% CI)	Sensitivity (95% CI)	Specificity (95% CI)
PCT	59	0.96 (0.5, 1.7) ng/ml^a	7376	3173	847	1060	2296	0.85 [0.82, 0.88]	0.79 [0.75, 0.83]	0.78 [0.74, 0.81]
CRP	45	84 (38, 140) mg/l	5654	2356	719	1014	1565	0.77 [0.73, 0.81]	0.75 [0.69, 0.79]	0.67 [0.58, 0.74]
IL-6	22	138 (75, 220) pg/ml	3450	1376	403	625	1046	0.79 [0.75, 0.82]	0.72 [0.63, 0.80]	0.73 [0.67, 0.79]
sTREM-1	8	123 (635, 594) pg/ml	831	406	82	126	217	0.85 [0.82, 0.88]	0.78 [0.66, 0.87]	0.78 [0.65, 0.87]
Presepsin	9	600 (415, 647) pg/ml	1510	777	155	168	410	0.88 [0.85, 0.90]	0.84 [0.79, 0.88]	0.77 [0.68, 0.84]
LBP	5	30 (24.35, 32) μg/ml	1136	305	208	191	432	0.71 [0.67, 0.75]	0.62 [0.53, 0.71]	0.70 [0.59, 0.79]
CD64	4	–	558	300	13	76	169	0.96 [0.94, 0.97]	0.87 [0.75, 0.94]	0.93 [0.87, 0.96]