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Table 1 Research results of biomarkers with at least 4 references

From: Biomarkers for diagnosis of sepsis in patients with systemic inflammatory response syndrome: a systematic review and meta-analysis

Test Studies Cut-off n TP FP FN TN AUC (95% CI) Sensitivity (95% CI) Specificity (95% CI)
PCT 59 0.96 (0.5, 1.7) ng/mla 7376 3173 847 1060 2296 0.85 [0.82, 0.88] 0.79 [0.75, 0.83] 0.78 [0.74, 0.81]
CRP 45 84 (38, 140) mg/l 5654 2356 719 1014 1565 0.77 [0.73, 0.81] 0.75 [0.69, 0.79] 0.67 [0.58, 0.74]
IL-6 22 138 (75, 220) pg/ml 3450 1376 403 625 1046 0.79 [0.75, 0.82] 0.72 [0.63, 0.80] 0.73 [0.67, 0.79]
sTREM-1 8 123 (635, 594) pg/ml 831 406 82 126 217 0.85 [0.82, 0.88] 0.78 [0.66, 0.87] 0.78 [0.65, 0.87]
Presepsin 9 600 (415, 647) pg/ml 1510 777 155 168 410 0.88 [0.85, 0.90] 0.84 [0.79, 0.88] 0.77 [0.68, 0.84]
LBP 5 30 (24.35, 32) μg/ml 1136 305 208 191 432 0.71 [0.67, 0.75] 0.62 [0.53, 0.71] 0.70 [0.59, 0.79]
CD64 4 558 300 13 76 169 0.96 [0.94, 0.97] 0.87 [0.75, 0.94] 0.93 [0.87, 0.96]
  1. TP true positive, FP false positive, FN false negative, TN true negative
  2. aMedian (25% percentiles, 75% percentiles)