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Table 2 Expression of studied proteins in omental fat of endometrial cancer patients with different body mass index values and obesity phenotypes (immunohistochemistry)

From: Features of omental adipose tissue in endometrial cancer patients with ‘standard’ or ‘metabolically healthy’ obesity: associations with tumor process characteristics

Group Expression score for proteins studied (M ± m) BMI (M ± m)
UCP1 Aromatase CD68 CD163
BMI <25.0 (8) 0.71 ± 0.41 0.81 ± 0.28 1.31 ± 0.28 2.00 ± 0.27 22.68 ± 0.46
BMI 25.0–29.9 (14) 0.46 ± 0.17 0.71 ± 0.16 0.79 ± 0.20 2.00 ± 0.21 28.63 ± 0.27
BMI ≥30.0 (28) 0.39 ± 0.10 0.88 ± 0.28 1.22 ± 0.19 2.43 ± 0.12 36.09 ± 1.05
SO (31) 0.48 ± 0.111 0.93 ± 0.122 1.26 ± 0.183 2.39 ± 0.13 34.84 ± 1.104
MHO (11) 0.23 ± 0.101 0.50 ± 0.172 0.60 ± 0.213 2.00 ± 0.19 30.11 ± 0.804
Endometrioid carcinomas (37) 0.49 ± 0.12 0.77 ± 0.11 1.00 ± 0.12 2.17 ± 0.12 32.45 ± 1.23
Non-endometrioid carcinomas (13) 0.41 ± 0.11 1.05 ± 0.22 1.27 ± 0.31 2.38 ± 0.21 30.00 ± 1.21
  1. Notes: The immunohistochemistry staining evaluation was based on a score system (result/score): (−) 0, (±) 0.5, (+) 1, (++) 2, (+++) 3, (++++) 4; BMI body mass index, SO “standard” obesity, MHO “metabolically healthy” obesity. Aromatase—estrogen synthetase; UCP1—an “uncoupling” protein involved in thermogenesis; CD68—a marker mostly expressed by macrophages (predominantly M1 type), including macrophages infiltrating fat tissue; CD163–M2 type macrophages marker [see (Bigornia et al. 2012) and “Discussion” section]. p (1) < 0.1; p (2, 3, 4) < 0.05. Number in brackets is the number of cases