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Table 2 Expression of studied proteins in omental fat of endometrial cancer patients with different body mass index values and obesity phenotypes (immunohistochemistry)

From: Features of omental adipose tissue in endometrial cancer patients with ‘standard’ or ‘metabolically healthy’ obesity: associations with tumor process characteristics

Group

Expression score for proteins studied (M ± m)

BMI (M ± m)

UCP1

Aromatase

CD68

CD163

BMI <25.0 (8)

0.71 ± 0.41

0.81 ± 0.28

1.31 ± 0.28

2.00 ± 0.27

22.68 ± 0.46

BMI 25.0–29.9 (14)

0.46 ± 0.17

0.71 ± 0.16

0.79 ± 0.20

2.00 ± 0.21

28.63 ± 0.27

BMI ≥30.0 (28)

0.39 ± 0.10

0.88 ± 0.28

1.22 ± 0.19

2.43 ± 0.12

36.09 ± 1.05

SO (31)

0.48 ± 0.111

0.93 ± 0.122

1.26 ± 0.183

2.39 ± 0.13

34.84 ± 1.104

MHO (11)

0.23 ± 0.101

0.50 ± 0.172

0.60 ± 0.213

2.00 ± 0.19

30.11 ± 0.804

Endometrioid carcinomas (37)

0.49 ± 0.12

0.77 ± 0.11

1.00 ± 0.12

2.17 ± 0.12

32.45 ± 1.23

Non-endometrioid carcinomas (13)

0.41 ± 0.11

1.05 ± 0.22

1.27 ± 0.31

2.38 ± 0.21

30.00 ± 1.21

  1. Notes: The immunohistochemistry staining evaluation was based on a score system (result/score): (−) 0, (±) 0.5, (+) 1, (++) 2, (+++) 3, (++++) 4; BMI body mass index, SO “standard” obesity, MHO “metabolically healthy” obesity. Aromatase—estrogen synthetase; UCP1—an “uncoupling” protein involved in thermogenesis; CD68—a marker mostly expressed by macrophages (predominantly M1 type), including macrophages infiltrating fat tissue; CD163–M2 type macrophages marker [see (Bigornia et al. 2012) and “Discussion” section]. p (1) < 0.1; p (2, 3, 4) < 0.05. Number in brackets is the number of cases
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