Table 1 Clinical variables and relationship with day 28th mortality
From: Mortality markers in nosocomial Klebsiella pneumoniae bloodstream infection
Variable | Died (91) | Living (99) | P value | HR (CI) | ||
|---|---|---|---|---|---|---|
N | % | N | % | |||
Demographic data | ||||||
Mean age | 64.91 ± 15.54 | 60.67 ± 14.94 | 0.074 | |||
Hospital stay before BSI | 27.82 ± 26.85 | 20.65 ± 19.57 | 0.085 | |||
Hospital stay after BSI | 12.81 ± 10.8 | 33.15 ± 28.62 | 0.0005 | |||
Male sex | 56 | 61.5 | 58 | 58.6 | 0.678 | |
Infection complication | ||||||
Sepsis | 91 | 100 | 76 | 76.8 | 0.0005 | 2.197 (1.86–2.59) |
Septic shock | 81 | 89 | 24 | 24.2 | 0.0005 | 25.31 (11.35–56.43) |
Need for ICU after infection | 91 | 100 | 66 | 66.7 | 0.0005 | 2.37 (1.98–2.85 43) |
BSI Source | ||||||
CLABSI | 25 | 27.5 | 31 | 31.3 | ||
Pneumonia | 29 | 31.9 | 15 | 15.2 | 0.006 | 2.61 (1.29–5.29) |
Pancreaticobiliary tract | 8 | 8.8 | 27 | 27.3 | 0.001 | 0.25 (0.11–0.6) |
Primer BSI | 12 | 13.2 | 8 | 8.1 | 0.251 | |
SSI | 10 | 11 | 9 | 9.1 | 0.810 | |
UTI | 6 | 6.6 | 7 | 7.1 | 0.896 | |
YDE | 2 | 2.2 | 2 | 2 | 1.00 | |
Indication of admittance into hospital | ||||||
Malignancy | 28 | 30.8 | 36 | 36.4 | 0.415 | |
Acute respiratory failure | 26 | 28.6 | 22 | 22.2 | 0.314 | |
Pancreaticobiliary tract infection | 9 | 9.9 | 23 | 23.2 | 0.013 | 0.36 (0.15–0.83) |
Neurological disorder | 9 | 9.9 | 23 | 23.2 | 0.019 | 0.15 (0.36–0.6) |
Pneumonia | 17 | 18.7 | 13 | 13.1 | 0.295 | |
Acute abdomen | 11 | 12.1 | 10 | 10.1 | 0.663 | |
Trauma | 8 | 8.8 | 10 | 10.1 | 0.758 | |
Acute renal failure | 13 | 14.3 | 5 | 5.1 | 0.028 | 3.13 (1.07–9.17) |
Cardiac disease | 11 | 12.1 | 6 | 6.1 | 0.144 | |
Sepsis | 8 | 8.8 | 6 | 6.1 | 0.422 | |
UTI | 4 | 4.4 | 4 | 4 | 0.903 | |
Chronic live disease | 4 | 4.4 | 3 | 3 | 0.618 | |
Co–morbid disease | ||||||
Hypertension | 45 | 49.5 | 50 | 50.5 | 0.885 | |
Malignancy | 34 | 37.4 | 43 | 43.4 | 0.394 | |
Diabetes mellitus | 27 | 29.7 | 25 | 25.3 | 0.495 | |
Neurological disorder | 21 | 23.1 | 27 | 27.3 | 0.506 | |
Coronary artery disease | 14 | 15.4 | 26 | 26.3 | 0.064 | |
Chronic liver failure | 27 | 29.7 | 11 | 11.1 | 0.001 | 3.37 (1.56–7.3) |
Cardiac insufficiency | 15 | 16.5 | 15 | 15.2 | 0.801 | |
Chronic obstructive pulmonary disease | 10 | 11 | 14 | 14.1 | 0.512 | |
Hepatic failure | 5 | 5.5 | 6 | 6.1 | 0.867 | |
Risk factor | ||||||
Urinary catheter | 76 | 83.5 | 66 | 66.7 | 0.007 | 2.53 (1.26–5.07) |
CVC | 71 | 78 | 63 | 63.6 | 0.029 | 2.02 (1.06–3.86) |
Mechanic ventilation | 69 | 75.8 | 56 | 56.6 | 0.005 | 2.4 (1.29–4.49) |
Blood and blood product transfusion | 51 | 56 | 41 | 41.4 | 0.043 | 1.8 (1.01–3.2) |
Drainage | 38 | 41.8 | 34 | 34.3 | 0.293 | |
Total parenteral nutrition | 31 | 34.1 | 28 | 28.3 | 0.390 | |
ERCP | 9 | 9.9 | 25 | 25.3 | 0.005 | 0.32 (0.14–0.74) |
Hemodialysis | 20 | 22 | 9 | 9.1 | 0.013 | 2.81 (1.2–6.56) |
Chemotherapy | 16 | 17.6 | 9 | 9.1 | 0.082 | |
Colostomy | 12 | 13.2 | 2 | 2 | 0.002 | 7.36 (1.6–33.89) |
Previous surgical procedure | ||||||
Gastrointestinal system | 14 | 15.4 | 14 | 14.1 | 0.809 | |
Musculo-skeletal system | 10 | 11 | 10 | 10.1 | 0.842 | |
Central nervous system | 7 | 7.7 | 8 | 8.1 | 0.921 | |
Genitourinary system | 4 | 4.4 | 9 | 9.1 | 0.256 | |
Bile ducts, liver and pancreas | 8 | 8.8 | 4 | 4 | 0.236 | |
Thorax surgery | 4 | 4.4 | 0 | 0 | 1.00 | |
Cardiovascular surgery | 1 | 1.1 | 1 | 1 | 0.051 | |
Operation | 41 | 45.1 | 42 | 42.4 | 0.715 | |
Appropriate empirical antibiotic therapy | 49 | 53.8 | 57 | 57.6 | 0.662 | |