Table 2 Fusion transcripts identified by NGS and validated by PCR
5′ gene (full name) | 5′ chr | 3′ gene (full name) | 3′ chr | Type | Verified | Express in TaxS | Express in TaxR |
|---|---|---|---|---|---|---|---|
TAF15 (TATA-box binding protein associated factor 15) | 17 | AP2B1 (adaptor related protein complex 2 beta 1 subunit) | 17 | Read through | Yes | Yes | No |
VCL (vinculin) | 10 | ADK (adenosine kinase) | 10 | Read through | Yes | Yes | No |
MYH9 (myosin, heavy chain 9, non-muscle) | 22 | EIF3D (eukaryotic translation initiation factor 3 subunit D) | 22 | Read through | Yes | No | Yes |
C14orf166 (chromosome 14 open reading frame 166) | 14 | SLC25A21 (solute carrier family 25 member 21) | 14 | Intra chromosomal | Yes | Yes | Yes |
UBE2L3 (ubiquitin conjugating enzyme E2 L3) | 22 | KRAS (kirsten rat sarcoma viral oncogene homolog) | 12 | Inter chromosomal | Yes | Yes | Yes |
LDLR (low density lipoprotein receptor) | 19 | RPL31P11 (ribosomal protein l31 pseudogene 11) | 15 | Read through | Yes | Yes | Yes (up regulated) |
IGSF9B (immunoglobulin superfamily member 9B) | 11 | FAM177A1 (family with sequence similarity 177 member A1) | 14 | Inter chromosomal | No | ||
CTSD (cathepsin D) | 11 | IFITM10 (interferon induced transmembrane protein 10) | 11 | Read through | Yes | Yes | Yes (up regulated) |
FLJ39739 | 1 | BC065231 | 1 | Intra chromosomal | Yes | Yes | Yes |
LOC100286793 | 1 | BC065231 | 1 | Intra chromosomal | Yes | Yes | Yes |
UBE2H (ubiquitin conjugating enzyme E2 H) | 7 | WIZ (widely interspaced zinc finger motifs) | 19 | Inter chromosomal | No | ||
SFPQ (splicing factor proline/glutamine-rich) | 1 | AL831889 (LOC100996496) | 1 | Read through | Yes | Yes | Yes |
CADM4 (cell adhesion molecule 4) | 19 | ZNF428 (zinc finger protein 428) | 19 | Read through | Yes | Yes | Yes |
GOLT1A (golgi transport 1A) | 1 | KISS1 (KiSS-1 metastasis-suppressor) | 1 | Read through | Yes | Yes | Yes |
SRGAP2P2 (SLIT-ROBO Rho GTPase activating protein 2B) | 1 | SRGAP2 (SLIT-ROBO Rho GTPase activating protein 2) | 1 | Intra chromosomal | Yes | Yes | Yes (up regulated) |
BTNL8 (butyrophilin like 8) | 5 | HMGA1 (high mobility group AT-Hook 1) | 6 | Inter chromosomal | No |