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Table 1 Mutations acquired after docetaxel treatment

From: Identification of mutations, gene expression changes and fusion transcripts by whole transcriptome RNAseq in docetaxel resistant prostate cancer cells

Gene Full name Mutation AA Type Non-synonymous In prostate tumor samples?
GALE UDP-galactose-4-epimerase TTT G[G/A]C AAT Single AA change G > D Damaging Yes yes
KIAA1522 KIAA1522 Deletion Frameshift   NA Yes yes
ATP5F1 ATP synthase, H + transporting, mitochondrial Fo complex subunit B1 GCC AA[G/T] TGC Single AA change K > N Damaging Yes  
ZNF669 Zinc finger protein 669 GAA [C/T]AG TGT Nonsense Q > * NA Yes yes
MDK Midkine (neurite growth-promoting factor 2) Deletion Frameshift   NA  
DDX23 DEAD-box helicase 23 GCT G[A/T]C AAA Single AA change D > V Damaging Yes yes
SFSWAP Splicing factor, suppressor of white-apricot homolog GAG [A/G]GG AGT Single AA change R > G Damaging Yes yes
TJP1 Tight junction protein 1 CCA C[G/A]T TTT Single AA change R > H Damaging Yes yes
CASC4 Cancer susceptibility candidate 4 AAT AT[G/A] CCT Single AA change M > I Damaging Yes  
MRPL28 Mitochondrial ribosomal protein L28 CAG G[A/G]C CCC Single AA change D > G Damaging Yes yes
STUB1 STIP1 homology and U-box containing protein 1 ATC G[C/T]G AAG Single AA change A > V Damaging Yes yes
UQCRC2 Ubiquinol-cytochrome C reductase core protein II ACA A[A/C]A GGA Single AA change K > T Damaging Yes yes
CHTF8 Chromosome transmission fidelity factor 8 CCC A[G/T]G TCA Single AA change R > M Damaging yes
KLHDC4 Kelch domain containing 4 GAC G[T/C]G TAT Single AA change V > A Damaging Yes yes
SPATA20 Spermatogenesis associated 20 GTC [C/T]CT CAC Single AA change P > S Damaging Yes yes
SMAD4 SMAD Family Member 4 Deletion Frameshift   NA Yes yes
LSM14A LSM14A MRNA processing body assembly factor CAG T[C/T]C ATG Single AA change S > F Damaging Yes yes
CALM3 Calmodulin 3 (phosphorylase kinase, delta) GGG [G/A]AG AAG Single AA change E > K NA Yes  
MYADM Myeloid-associated differentiation marker TCC C[C/T]T CGG Single AA change P > L Damaging Yes yes
ODC1 Ornithine decarboxylase 1 CAT G[T/C]G GGT Single AA change V > A Damaging Yes yes
FOSL2 FOS like antigen 2 GAC [C/A]TG CAG Single AA change L > M Damaging Yes yes
CYBRD1 Cytochrome B reductase 1 TTC [G/A]GG GCC Single AA change G > R Damaging Yes  
BOK BCL2-related ovarian killer GAC [T/C]GT GTG Single AA change C > R Damaging Yes  
ITCH Itchy E3 ubiquitin protein ligase AAT G[G/A]T GAA Single AA change G > D Damaging Yes yes
DIP2A Disco interacting protein 2 homolog A AAC [G/A]TC TTC Single AA change V > I Damaging Yes yes
BID BH3 interacting domain death agonist ACC [G/A]TA GCA Single AA change V > I Damaging Yes yes
NUP210 Nucleoporin 210 kDa ATA [G/T]CC TAC Single AA change A > S Damaging Yes yes
HYAL2 Hyaluronoglucosaminidase 2 CTG [C/T]GA CCT Nonsense R > * NA Yes  
RBM15B RNA binding motif protein 15B ACC CA[G/T] CTG Single AA change Q > H Damaging Yes yes
CTBP1 C-terminal binding protein 1 TCC A[C/T]G CAG Single AA change T > M Damaging Yes yes
TACC3 Transforming acidic coiled-coil containing protein 3 AGC T[C/T]T TCC Single AA change S > F Damaging Yes yes
AFAP1 Actin filament associated protein 1 TCA [G/C]AG GCC Single AA change E > Q Damaging Yes yes
MCTP1 Multiple C2 and transmembrane domain containing 1 ATG G[G/T]C TCA Single AA change G > V Damaging Yes yes
MAN2A1 Mannosidase alpha class 2A member 1 CTT A[T/A]C CAG single aa change I > N Damaging Yes yes
C5orf15 Chromosome 5 open reading frame 15 Deletion Frameshift   NA Yes  
UIMC1 Ubiquitin interaction motif containing 1 GAA G[C/A]T AGG Single AA change A > D Damaging Yes yes
MAML1 Mastermind like transcriptional coactivator 1 Deletion Frameshift   NA Yes yes
C6orf141 Chromosome 6 open reading frame 141 CGG [G/T]GG CCT Single AA change G > W Damaging Yes yes
CROT Carnitine O-octanoyltransferase TTT [T/C]CC AAA Single AA change S > P Damaging Yes yes
CAPZA2 Capping actin protein of muscle Z-line alpha subunit 2 AGG A[A/C]G GAG Single AA change K > T Damaging Yes yes
ASB6 Ankyrin Repeat and SOCS box containing 6 AAC [C/T]GC TTC Single AA change R > C Damaging Yes yes
ABCA2 ATP binding cassette subfamily a member 2 GGC C[G/A]C TTC Single AA change R > H Damaging Yes yes
  1. Mutation and amino acid changing were showed in column 3 and 4. Mutation Type was analyzed by program SIFT and gained by setting cutoff as 0.05. ‘Damaging’ means that the substitution is predicted to affect protein function. NA not analyzed. The last column shows the connection between cell lines and tumor samples. It is labeled “yes” if mutation can be found in both cell line sequence and tumor sample sequence