Table 1 Mutations acquired after docetaxel treatment
Gene | Full name | Mutation | AA | Type | Non-synonymous | In prostate tumor samples? | |
|---|---|---|---|---|---|---|---|
GALE | UDP-galactose-4-epimerase | TTT G[G/A]C AAT | Single AA change | G > D | Damaging | Yes | yes |
KIAA1522 | KIAA1522 | Deletion | Frameshift | NA | Yes | yes | |
ATP5F1 | ATP synthase, H + transporting, mitochondrial Fo complex subunit B1 | GCC AA[G/T] TGC | Single AA change | K > N | Damaging | Yes | |
ZNF669 | Zinc finger protein 669 | GAA [C/T]AG TGT | Nonsense | Q > * | NA | Yes | yes |
MDK | Midkine (neurite growth-promoting factor 2) | Deletion | Frameshift | NA | – | ||
DDX23 | DEAD-box helicase 23 | GCT G[A/T]C AAA | Single AA change | D > V | Damaging | Yes | yes |
SFSWAP | Splicing factor, suppressor of white-apricot homolog | GAG [A/G]GG AGT | Single AA change | R > G | Damaging | Yes | yes |
TJP1 | Tight junction protein 1 | CCA C[G/A]T TTT | Single AA change | R > H | Damaging | Yes | yes |
CASC4 | Cancer susceptibility candidate 4 | AAT AT[G/A] CCT | Single AA change | M > I | Damaging | Yes | |
MRPL28 | Mitochondrial ribosomal protein L28 | CAG G[A/G]C CCC | Single AA change | D > G | Damaging | Yes | yes |
STUB1 | STIP1 homology and U-box containing protein 1 | ATC G[C/T]G AAG | Single AA change | A > V | Damaging | Yes | yes |
UQCRC2 | Ubiquinol-cytochrome C reductase core protein II | ACA A[A/C]A GGA | Single AA change | K > T | Damaging | Yes | yes |
CHTF8 | Chromosome transmission fidelity factor 8 | CCC A[G/T]G TCA | Single AA change | R > M | Damaging | – | yes |
KLHDC4 | Kelch domain containing 4 | GAC G[T/C]G TAT | Single AA change | V > A | Damaging | Yes | yes |
SPATA20 | Spermatogenesis associated 20 | GTC [C/T]CT CAC | Single AA change | P > S | Damaging | Yes | yes |
SMAD4 | SMAD Family Member 4 | Deletion | Frameshift | NA | Yes | yes | |
LSM14A | LSM14A MRNA processing body assembly factor | CAG T[C/T]C ATG | Single AA change | S > F | Damaging | Yes | yes |
CALM3 | Calmodulin 3 (phosphorylase kinase, delta) | GGG [G/A]AG AAG | Single AA change | E > K | NA | Yes | |
MYADM | Myeloid-associated differentiation marker | TCC C[C/T]T CGG | Single AA change | P > L | Damaging | Yes | yes |
ODC1 | Ornithine decarboxylase 1 | CAT G[T/C]G GGT | Single AA change | V > A | Damaging | Yes | yes |
FOSL2 | FOS like antigen 2 | GAC [C/A]TG CAG | Single AA change | L > M | Damaging | Yes | yes |
CYBRD1 | Cytochrome B reductase 1 | TTC [G/A]GG GCC | Single AA change | G > R | Damaging | Yes | |
BOK | BCL2-related ovarian killer | GAC [T/C]GT GTG | Single AA change | C > R | Damaging | Yes | |
ITCH | Itchy E3 ubiquitin protein ligase | AAT G[G/A]T GAA | Single AA change | G > D | Damaging | Yes | yes |
DIP2A | Disco interacting protein 2 homolog A | AAC [G/A]TC TTC | Single AA change | V > I | Damaging | Yes | yes |
BID | BH3 interacting domain death agonist | ACC [G/A]TA GCA | Single AA change | V > I | Damaging | Yes | yes |
NUP210 | Nucleoporin 210 kDa | ATA [G/T]CC TAC | Single AA change | A > S | Damaging | Yes | yes |
HYAL2 | Hyaluronoglucosaminidase 2 | CTG [C/T]GA CCT | Nonsense | R > * | NA | Yes | |
RBM15B | RNA binding motif protein 15B | ACC CA[G/T] CTG | Single AA change | Q > H | Damaging | Yes | yes |
CTBP1 | C-terminal binding protein 1 | TCC A[C/T]G CAG | Single AA change | T > M | Damaging | Yes | yes |
TACC3 | Transforming acidic coiled-coil containing protein 3 | AGC T[C/T]T TCC | Single AA change | S > F | Damaging | Yes | yes |
AFAP1 | Actin filament associated protein 1 | TCA [G/C]AG GCC | Single AA change | E > Q | Damaging | Yes | yes |
MCTP1 | Multiple C2 and transmembrane domain containing 1 | ATG G[G/T]C TCA | Single AA change | G > V | Damaging | Yes | yes |
MAN2A1 | Mannosidase alpha class 2A member 1 | CTT A[T/A]C CAG | single aa change | I > N | Damaging | Yes | yes |
C5orf15 | Chromosome 5 open reading frame 15 | Deletion | Frameshift | NA | Yes | ||
UIMC1 | Ubiquitin interaction motif containing 1 | GAA G[C/A]T AGG | Single AA change | A > D | Damaging | Yes | yes |
MAML1 | Mastermind like transcriptional coactivator 1 | Deletion | Frameshift | NA | Yes | yes | |
C6orf141 | Chromosome 6 open reading frame 141 | CGG [G/T]GG CCT | Single AA change | G > W | Damaging | Yes | yes |
CROT | Carnitine O-octanoyltransferase | TTT [T/C]CC AAA | Single AA change | S > P | Damaging | Yes | yes |
CAPZA2 | Capping actin protein of muscle Z-line alpha subunit 2 | AGG A[A/C]G GAG | Single AA change | K > T | Damaging | Yes | yes |
ASB6 | Ankyrin Repeat and SOCS box containing 6 | AAC [C/T]GC TTC | Single AA change | R > C | Damaging | Yes | yes |
ABCA2 | ATP binding cassette subfamily a member 2 | GGC C[G/A]C TTC | Single AA change | R > H | Damaging | Yes | yes |