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Table 3 The correlations between overall survival and various clinicopathological factors

From: The significance of the C-reactive protein to albumin ratio as a marker for predicting survival and monitoring chemotherapeutic effectiveness in patients with unresectable metastatic colorectal cancer

  Univariate analysis Multivariate analysis
Hazard ratio 95 % CI p value Hazard ratio 95 % CI p value
Gender (female vs. male) 1.473 0.895–2.423 0.128    
Age (≥65 vs. <65) 1.492 0.907–2.454 0.115    
Location of primary tumor (colon vs. rectum) 1.273 0.769–2.108 0.348    
Detection of unresectable tumor (synchronous vs. metachronous) 1.595 0.946–2.688 0.080 1.099 0.595–2.030 0.763
Histological type (poorly, mucinous vs. well, moderately) 1.417 0.688–2.916 0.344    
Peritoneal dissemination (yes vs. no) 1.124 0.609–2.075 0.708    
The number of organs affected by metastasis (≥2 vs. <2) 1.775 1.078–2.923 0.024 1.115 0.622–1.997 0.715
Pretreatment CEA (>5 ng/ml vs. ≤5 ng/ml) 2.193 0.940–5.113 0.069 1.370 0.526–3.571 0.520
Molecular targeted therapy (yes vs. no) 0.391 0.227–0.676 0.001 0.341 0.186–0.626 0.001
Pretreatment CRP/ALB ratio (>0.183 vs. ≤0.183) 2.301 1.390–3.807 0.001 1.866 1.057–3.295 0.031
Pretreatment NLR (>3 vs. ≤3) 3.777 2.191–6.511 <0.001 2.706 1.483–4.939 0.001
  1. CEA carcinoembryonic antigen, CRP/ALB ratio C-reactive protein to albumin ratio, NLR neutrophil to lymphocyte ratio