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Table 3 Distribution of alleles and genotype frequencies and comparison in HCV patients

From: SOCS3 mRNA expression and polymorphisms as pretreatment predictor of response to HCV genotype 3a IFN-based treatment

  

Non-relapsers n (%)

Relapser n (%)

OR crude (95 % CI)

p value

OR Adjusted* (95 % CI)

p value adjusted*

SOCS3 rs4969168 (G/A) model

 

Genotype

      

Co-dominant

GG

61 (53.0)

12 (46.2)

–

0.759

–

–

GA

44 (38.3)

12 (46.2)

1.386 (0.570–3.373)

0.471

1.242 (0.498–3.100)

0.642

AA

10 (8.7)

2 (7.7)

1.017 (0.197–5.238)

0.984

0.872 (0.163–4.658)

0.873

Recessive

GG and GA

105 (91.3)

24 (92.3)

0.875 (0.180–4.255)

0.868

0.784 (0.156–3.928)

0.767

AA

10 (8.7)

2 (7.7)

    

Dominant

GG

61 (53.0)

12 (50.0)

1.318 (0.561–3.095)

0.868

1.173 (0.487–2.828)

0.722

GA and AA

54 (47.0)

14 (50.0)

    
 

Alleles

      
 

G

166 (72.7)

36 (69.2)

0.8675 (0.450 –1.671)

0.6709

0.8675 (0.4503–1.6712)

0.6709

 

A

64 (27.8)

16 (30.7)

    

SOCS3 rs4969170(A/G) model

 

Genotype

      

Co-dominant

AA

25 (21.7)

3 (11.5)

–

0.473

–

–

AG

32 (27.8)

9 (34.6)

2.344 (0.574–9.576)

0.236

1.951 (0.456–8.346)

0.367

GG

58 (50.4)

14 (53.8)

2.011 (0.531–7.622)

0.304

1.698 (0.427–6.756)

0.452

Recessive

AA and AG

57 (49.6)

12 (46.2)

2.130 (0.591–7.676)

0.753

1.069 (0.445–2.568)

0.881

GG

58 (50.4)

14 (53.8)

    

Dominant

AA

25 (21.7)

3 (11.5)

1.147 (0.488–2.691)

0.239

1.790 (0.473–6.768)

0.391

AG and GG

90 (78.3)

23 (88.5)

    
 

Alleles

      
 

A

82 (35.6)

37 (71.1)

4.452 (2.306 –8.595)

<0.0001

4.452 (2.3060–8.595)

<0.0001

 

G

148 (64.3)

15 (28.8)

    

SOCS3 rs12952093(C/A) model

 

Genotype

      

Co-dominant

CC

22 (19.1)

4 (15.4)

–

0.905

–

–

CA

25 (21.7)

6 (23.1)

1.320 (0.329–5.293)

0.695

1.564 (0.377–6.489)

0.538

AA

68 (59.1)

16 (61.5)

1.294 (0.391 –4.282)

0.673

1.374 (0.401–4.705)

0.613

Recessive

CC and CA

47 (40.9)

10 (38.5)

1.106 (0.462–2.648)

0.821

1.076 (0.433–2.673)

0.875

AA

68 (59.1)

16 (61.5)

    

Dominant

CC

22 (19.1)

4 (15.4)

1.301 (0.407–4.160)

0.656

1.425 (0.433–4.686)

0.560

CA and AA

93 (80.9)

22 (84.6)

    
 

Alleles

      
 

C

69 (30.0)

14 (26.9)

0.859 (0.437–1.687)

0.660

0.859 (0.437–1.687)

0.660

 

A

161 (70.0)

38 (73.0)

    
  1. OR odd ratio, CI confidence interval, NA not applicable
  2. * Adjusted on the basis of age, gender, and viral titer. p ≤ 0.05 statistically significant
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