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Table 3 Significance of EORTC QLQ-L13 and LCSS scores for overall survival of the lung cancer patients (Univariate and mulitvariate Cox’s regression results)

From: Comparison of generic and lung cancer-specific quality of life instruments for predictive ability of survival in patients with advanced lung cancer

Variables

LC13

Mean (sd)

N

Crude HR (95 % CI)

Adjusted HRa (95 % CI)

Dispnoea (ref = 0)

30.5

235

1.00

1.00

>0

(25.7)

64

0.83 (0.61–1.12)

1.01 (1.00–1.01)

Cough (ref = 0)

39.6

220

1.00

1.00

>0

(32.1)

79

0.93 (0.71–1.22)

1.00 (1.00–1.01)

Hemoptysis (ref = 0)

9.9

67

1.00

1.00

>0

(21.0)

232

1.01 (0.75–1.34)

1.00 (1.00–1.01)

Sore Mouth (ref = 0)

5.8

40

1.00

1.00

>0

(16.3)

259

1.14 (0.79–1.63)

1.00 (0.99–1.01)

Dysphagia (ref = 0)

9.0

54

1.00

1.00

>0

(21.4)

245

0.88 (0.64–1.21)

1.01 (1.00–1.01)

Peripheral neuropathy (ref = 0)

14.0

83

1.00

1.00

>0

(26.3)

216

0.98 (0.75–1.29)

1.01 (1.00–1.01)

Hair loss (ref = 0)

5.9

28

1.00

1.00

>0

(25.7)

269

1.40 (0.91–2.14)

1.00 (0.99–1.00)

Chest pain (ref = 0)

24.5

149

1.00

1.00

>0

(29.7)

150

0.85 (0.67–1.08)

1.00 (1.00–1.01)

Pain in arm or shoulder (ref = 0)

18.1

108

1.00

1.00

>0

(27.7)

191

0.96 (0.74–1.23)

1.00 (1.00–1.01)

Other pain sites (ref = 0)

20.7

186

1.00

1.00

>0

(16.2)

113

1.07 (0.83–1.36)

1.00 (0.99–1.01)

LCSS (Lung Cancer Symptom Scale)

    

 LCSS index score (30.00 ≤ as reference)

40.5

96

1.00

1.00

30.01 > LCSS.I ≤ 45.99

(20.6)

99

0. 77(0.57–1.05)

0.82 (0.60–1.21)

≥46.00

 

101

1.16 (0.86–1.55)

1.06 (0.78–1.42)

 LCSS symptom score (27.00 ≤ as reference)

38.1

98

1.00

1.00

27.01 > LCSS.S ≤ 43.69

(21.7)

96

0.74 (0.54–1.00)

0.76 (0.56–1.04)

≥43.70

 

102

1.20 (0.90–1.62)

1.12 (0.83–1.52)

  1. * P < 0.05; ** P < 0.01; *** P < 0.001
  2. aAdjusted for age, gender, clinical stage (as TNM), and comorbidiy