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Table 2 Significance of QLQ-C30 scores for overall survival of the lung cancer patients (Univariate and mulitvariate Cox’s regression results)

From: Comparison of generic and lung cancer-specific quality of life instruments for predictive ability of survival in patients with advanced lung cancer

Variables

Mean (SD)

N

Crude HR (95 % CI)

Adjusted HRa (95 % CI)

Global QoL (≥66.67 as reference)

57.6

134

1.00

1.00

50.00 > GL ≤ 66.66

(24.3)

84

1.09 (0.79–1.52)

1.02 (0.73–1.43)

≤50,00

 

81

1.57 (1.17–2.12)***

1.39 (1.03–1.88)*

Physical functioning (≥86.67 as reference)

70.4

115

1.00

1.00

66.66 > PF ≤ 86.66

(27.7)

102

1.27 (0.93–1.75)

1.11 (0.80–1.54)

≤66.65

 

82

2.09 (1.53–2.85)***

1.65 (1.19–2.29)**

Role functioning (≥100.0 as reference)

70.7

151

1.00

1.00

66.66 > RF ≤ 99.99

(32.4)

22

1.39 (0.87–2.21)

1.32 (0.81–2.16)

≤66.65

 

126

1.56 (1.21–2.02)**

1.36 (1.04–1.78)*

Emotional functioning (≥91.66 as reference)

77.8

103

1.00

1.00

66.66 > EF ≤ 91.65

(23.3)

97

1.16 (0.86–1.56)

1.28 (0.95–1.74)

≤66.65

 

99

1.06 (0.78–1.42)

0.98 (0.72–1.34)

Cognitive functioning (≥100.0 as reference)

86.5

72

1.00

1.00

83.33 > CF ≤ 99.99

(18.6)

59

1.18 (0.86–1.62)

1.08 (0.78–1.48)

≤83.32

 

168

1.29 (0.97–1.73)

1.19 (0.87–1.61)

Social functioning (≥100.0 as reference)

74.7

131

1.00

1.00

66.66 > SF ≤ 99.99

(31.6)

21

1.26 (0.78–2.04)

1.22 (0.75–2.00)

≤66.65

 

147

1.13 (0.88–1.45)

0.99 (0.77–1.429)

Fatigue (=0 as reference)

43.1

36

1.00

1.00

>0

(28.8)

263

2.08 (1.39–3.11)***

1.73 (1.14–2.61)**

Pain (=0 as reference)

36.3

79

1.00

1.00

>0

(31.2)

220

1.31 (0.99–1.72)

1.10 (0.82–1.47)

Nausea/vomiting (=0 as reference)

11.1

213

1.00

1.00

>0

(21.6)

86

1.16 (0.89–1.51)

1.13 (0.86–1.49)

Dyspnoea (=0 as reference)

34.1

110

1.00

1.00

>0

(32.8)

188

1.33 (1.03–1.71)*

1.22 (0.94–1.58)

Insomnia (=0 as reference)

32.4

120

1.00

1.00

>0

(33.3)

178

1.66 (1.29–2.14)***

1.44 (1.10–1.88)**

Appetite loss (=0 as reference)

36.2

110

1.00

1.00

>0

(34.9)

189

1.40 (1.10–1.80)**

1.42 (1.10–1.84)**

Constipation (=0 as reference)

20.6

179

1.00

1.00

>0

(29.6)

120

1.54 (1.21–1.97)**

1.61 (1.25–2.07)***

Diarrhoea (=0 as reference)

8.9

249

1.00

1.00

>0

(22.4)

50

1.27 (0.92–1.74)

1.14 (0.82–1.57)

Financial difficulties (=0 as reference)

29.3

146

1.00

1.00

>0

(34.6)

153

1.14 (0.89–1.45)

0.99 (0.77–1.27)

  1. * P < 0.05; ** P < 0.01; *** P < 0.001
  2. aAdjusted for age, gender, clinical stage (as TNM), and comorbidiy