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Table 4 Chemical structure of the chalcone derivatives and their XO inhibitory activity

From: Design and synthesis of chalcone derivatives as potential non-purine xanthine oxidase inhibitors

Compound	R₁	R₂	R₃	R₄	R₅	R₆	IC₅₀ (μM)
3	H	H	H	H	OH	OH	40.9
4	OH	H	OH	H	H	H	>100
5	OH	H	OH	H	OH	OH	4.3
6	OH	H	OH	OH	H	OH	16.3
7	OMe	H	OH	H	OH	OH	3.9
8	OH	H	OH	H	OH	OMe	36.7
9	OH	H	OH	H	OMe	OMe	>100
10	OH	H	OMe	H	OH	OH	19.2
11	OMe	H	OMe	H	OH	OH	2.5
12	OH	H	OH	OH	H	OMe	21.8
13	OH	Caffeoyl	OMe	H	OH	OH	2.4
14	H	H	H	H	OH	OMe	>100
15	H	H	H	H	OMe	OMe	>100
16	OH	H	OMe	H	OMe	OMe	>100
17	OH	H	OAc	H	OAc	OAc	>100
18	H	H	H	H	H	H	>100
Allopurinol							2.5

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