From: Design and synthesis of chalcone derivatives as potential non-purine xanthine oxidase inhibitors
Entry | Temp. (°C) | Time (h) | Molar ratio (1a/2b) | Yield (%) |
---|---|---|---|---|
1a | 30 | 12 | 1:1 | 24.1 |
2a | 30 | 24 | 1:1 | 29.2 |
3a | 30 | 36 | 1:1 | 36.2 |
4a | 30 | 48 | 1:1 | 38.3 |
5b | 30 | 4 | 1:1 | 23.8 |
6b | 30 | 5 | 1:1 | 28.4 |
7b | 30 | 6 | 1:1 | 32.7 |
8b | 30 | 7 | 1:1 | 36.9 |
9b | 30 | 8 | 1:1 | 44.0 |
10b | 30 | 10 | 1:1 | 40.8 |
11b | 30 | 12 | 1:1 | 38.1 |
12b | 60 | 8 | 1:1 | 47.1 |
13b | 70 | 8 | 1:1 | 50.9 |
14b | 80 | 8 | 1:1 | 57.1 |
15b | 90 | 8 | 1:1 | 55.4 |
16b | 80 | 8 | 1.5:1 | 64.3 |
17b | 80 | 8 | 2:1 | 69.8 |
18b | 80 | 8 | 2.5:1 | 54.2 |
19b | 80 | 8 | 3:1 | 47.6 |