From: Design and synthesis of chalcone derivatives as potential non-purine xanthine oxidase inhibitors
Entry | Temp. (oC) | Time (hours) | Molar ratio (1a/2a) | Volume of MeOH (mL) | Yield (%) |
---|---|---|---|---|---|
1a | 30 | 6 | 1:1 | 1.00 | 24.1 |
2a | 30 | 12 | 1:1 | 1.00 | 29.2 |
3a | 30 | 18 | 1:1 | 1.00 | 36.2 |
4a | 30 | 24 | 1:1 | 1.00 | 38.3 |
5b | 30 | 2 | 1:1 | 1.00 | 24.7 |
6b | 30 | 3 | 1:1 | 1.00 | 27.5 |
7b | 30 | 4 | 1:1 | 1.00 | 29.0 |
8b | 30 | 5 | 1:1 | 1.00 | 31.9 |
9b | 30 | 6 | 1:1 | 1.00 | 38.0 |
10b | 30 | 7 | 1:1 | 1.00 | 36.8 |
11b | 30 | 8 | 1:1 | 1.00 | 36.1 |
12b | 60 | 6 | 1:1 | 1.00 | 46.3 |
13b | 70 | 6 | 1:1 | 1.00 | 52.1 |
14b | 80 | 6 | 1:1 | 1.00 | 47.7 |
15b | 90 | 6 | 1:1 | 1.00 | 45.1 |
16b | 70 | 6 | 1:1 | 0.25 | 32.2 |
17b | 70 | 6 | 1:1 | 0.50 | 40.8 |
18b | 70 | 6 | 1:1 | 0.75 | 46.5 |
19b | 70 | 6 | 1:1 | 1.50 | 51.5 |
20b | 70 | 6 | 1.5:1 | 1.00 | 70.6 |
21b | 70 | 6 | 2:1 | 1.00 | 77.3 |
22b | 70 | 6 | 2.5:1 | 1.00 | 79.8 |
23b | 70 | 6 | 3:1 | 1.00 | 81.6 |