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Table 2 Optimization of parameters for the synthesis of 3

From: Design and synthesis of chalcone derivatives as potential non-purine xanthine oxidase inhibitors

Entry

Temp. (oC)

Time (hours)

Molar ratio

(1a/2a)

Volume of MeOH (mL)

Yield (%)

1a

30

6

1:1

1.00

24.1

2a

30

12

1:1

1.00

29.2

3a

30

18

1:1

1.00

36.2

4a

30

24

1:1

1.00

38.3

5b

30

2

1:1

1.00

24.7

6b

30

3

1:1

1.00

27.5

7b

30

4

1:1

1.00

29.0

8b

30

5

1:1

1.00

31.9

9b

30

6

1:1

1.00

38.0

10b

30

7

1:1

1.00

36.8

11b

30

8

1:1

1.00

36.1

12b

60

6

1:1

1.00

46.3

13b

70

6

1:1

1.00

52.1

14b

80

6

1:1

1.00

47.7

15b

90

6

1:1

1.00

45.1

16b

70

6

1:1

0.25

32.2

17b

70

6

1:1

0.50

40.8

18b

70

6

1:1

0.75

46.5

19b

70

6

1:1

1.50

51.5

20b

70

6

1.5:1

1.00

70.6

21b

70

6

2:1

1.00

77.3

22b

70

6

2.5:1

1.00

79.8

23b

70

6

3:1

1.00

81.6

  1. Reaction was carried out at KOH 10 M
  2. aUsing CH
  3. bUsing UA