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Table 1 Optimal condition for the concentration of KOH

From: Design and synthesis of chalcone derivatives as potential non-purine xanthine oxidase inhibitors

Entry

CKOH (M)

Yield (%)

1a

6

28.3

2a

8

31.1

3a

10

39.7

4a

12

37.8

5a

14

34.4

6b

10

20.5

7b

11

24.5

8b

12

26.8

9b

13

28.4

10b

14

33.4

11b

d

32.8

12c

10

8.3

13c

11

17.5

14c

12

22.8

15c

13

7.1

  1. aSynthesis of chalcone in group I: 1a/2a = 1/1; MeOH (1.00 mL); 30 °C; UA; 6 h
  2. bSynthesis of chalcone in group II: 1a/2b = 1/1; H2O (1.00 mL); 30 °C; UA; 6 h
  3. cSynthesis of 7: 1a/2c = 2/1; H2O (1.00 mL); 80 °C; UA; 8 h
  4. dUsing a solid KOH