Fig. 3

ROC curve of CSF HMGB1 showing the threshold value of CSF HMGB1 in the diagnosis of TBM. a CSF HMGB1 reached a sensitivity of 61.02 %, a specificity of 89.94 %, a positive predictive value of 67.92 %, and a negative predictive value of 86.86 % (cut-off value: 3.4 ng/ml; area under the curve: 0.836); b In tuberculosis patients, CSF HMGB1 reached a sensitivity of 79.49 %, a specificity of 94.52 %, a positive predictive value of 88.57 %, and a negative predictive value of 89.61 % (cut-off value: 3.8 ng/ml; area under the curve: 0.888)