Regulatory mechanisms of microRNAs in lung cancer stem cells

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Table 1 Regulatory miRNAs involved in LCSCs

MicroRNAs	Source	Tumor type	Correlated factors	Target genes	Cell surface markers	Signaling pathway	References
miR-145	Human lung cancer tissues	Adenocarcinoma	Sox2, fascin	Oct4	SP/CD133	Oct4/sox2/fascin	Chiou et al. (2012), Zhang et al. (2011), Hu et al. (2014),
miR-31	A549cell lines/side population cells	Adenocarcinoma	G0/G1 phase	G0/G1 phase	SP/CD133/326	Unknown	Hua et al. (2012), Lin et al. (2012)
miR-7	A549cell lines/side population cells	Adenocarcinoma	G1/S phase	G0/G1 phase	SP/CD133/326	Unknown	Hua et al. (2012), Lin et al. (2012)
miR-34a	A549cell lines/H460/H1299/mice	Non-small cell lung cancer	p53/BCL2	p53/BCL2	CD44/CD133	p53/Notch1/Nontch2	Shi et al. (2014), Bommer et al. (2007), Li et al. (2009), Pang et al. (2010b), Balca-Silva et al. (2012)
miR-200b	SPC-A1/H1299/human lung cancer tissues	Adenocarcinoma	HDAC1/Oct-4/SOX-2/Bmi-1	Suppressor of zeste-12 (Suz-12)	CD133/326	The HDAC1/miR-200b/Suz-12-E-cadherin signaling	Chen et al. (2014)