Fig. 5
From: Regulatory mechanisms of microRNAs in lung cancer stem cells
Suppressor of zeste-12 (Suz-12) was identified as a direct and functional target of miR-200b. Histone deacetylase (HDAC) 1 repressed miR-200b through a specificity protein (Sp) 1-dependent mechanism in which HDAC1 and Sp1 could bind to the miR-200b promoters (pro). Restoration ofmiR-200b by HDAC1 repression significantly suppressed CSC formation and reversed chemoresistance of CSCs by reducing Suz-12-E-cadherin