Fig. 3

As is shown in a, let-7 and miR-31 are regulators for maintaining the balance between differentiation and quiescence for LCSCs. Cell cycle studies further revealed that increasing miR-31 could enhance the proliferation of LCSCs by speeding up the cell cycle in the G0/G1 phase, whereas reduced let-7 induced cell proliferation of LCSCs by accelerating the G1/Sphase transition (b)