Fig. 2

miR-145 is transcribed by RNA polymerase II (Pol II) into long primary miRNA145 transcripts, which are cleaved in the nucleus by the RNase III enzyme Drosha, resulting in a hairpin precursor form called pre-miRNA. Pre-miRNA is exported from the nucleus to the cytoplasmby exportin 5 and is further processed by the enzyme Dicer, which produces a transient miRNA duplex that includes a mature miR-145. miR-145 targets sites of the 3′UTRs of Oct4, Sox2, and Fascin1 and represses Oct4, Sox2, and Fascin1 to inhibit the properties of LCSCs