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Table 3 Susceptibilities of standard Candida spp. to HC alone and in combination with AMB and 5-FC (2:1) ratio

From: Antifungal activity of dual combination of hydroxychavicol with commercialized agents against oral Candida species

Species

MIC (µg/mL) alonea

MIC(µg/mL) combination (2:1) ratioa

 

HC

Amp B

5-FC

HCb

Amp B

HC + Amp B FICI

INT

HCc

5-FC

HC + 5-FC FICI

INT

C. albicans

240

8

2

2

0.5

0.07

SYN

30

8

>4

ANT

C. parapsilosis

120

8

2

2

0.5

0.08

SYN

15

4

2.25

IND

C. tropicalis

240

4

8

8

2

0.53

IND

30

8

1.12

IND

C. dubliniensis

120

4

2

4

1

0.28

SYN

30

8

>4

ANT

C. lusitaniae

240

15

4

8

2

0.17

SYN

15

4

1.06

IND

  1. MIC and FICI values are shown as a mean of three independent experiments
  2. ANT antagonism, IND indifference, SYN synergy, INT interpretation
  3. aThe MIC end point is based on the lowest drug concentration producing a decrease of 50 % inhibition of fungal growth compared to untreated
  4. bMIC of HC when in combination with AMB
  5. cMIC of HC when in combination with 5-FC
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