Skip to main content

Advertisement

Table 3 Influence of curcumin on metabolizing enzymes, antioxidants and lipid peroxides in liver of control and experimental rats

From: Multivariate analysis and molecular interaction of curcumin with PPARγ in high fructose diet induced insulin resistance in rats

Biochemical parameters Group 1 Group 2 Group 3 Group 4
Hexokinase (mM of glucose phosphorylated/h/mg protein) 4.62 ± 0.16 2.59 ± 0.27* 3.62 ± 0.23 5.38 ± 0.30#
Glucose 6-Phosphatase (mM of inorganic phosphorous liberated/min/mg protein) 0.24 ± 0.03 5.69 ± 0.30* 0.24 ± 0.03 1.59 ± 0.15#
Fructose 1,6-bis phosphatase (mM of inorganic phosphorous liberated/h/mg protein) 116.25 ± 4.54 167.05 ± 11.10* 131.50 ± 35.10 140.39 ± 5.26#
Catalase (Units/mg of protein) 108.67 ± 1.81 69.10 ± 2.06* 108.27 ± 1.85 107.82 ± 1.66#
Super oxide dismutase (Units/mg protein) 1526.39 ± 18.29 685.25 ± 4.44* 1337.80 ± 11.87 1135.74 ± 8.20#
Glutathione peroxidase (Units/mg protein) 142.00 ± 1.86 21.48 ± 1.11* 93.34 ± 1.81 137.81 ± 2.32#
Vitamin C (µM/mg of tissue) 1.60 ± 0.06 0.70 ± 0.02* 1.6 ± 0.06 1.15 ± 0.02#
Vitamin E (µM/mg of tissue) 1.56 ± 0.03 0.83 ± 0.04* 1.54 ± 0.04 2.22 ± 0.008#
Glutathione reductase (mg/100 g of tissue) 1.59 ± 0.04 0.06 ± 0.003* 1.43 ± 0.04 1.06 ± 0.04#
Thiobarbituric acid reactive substances (mM/100 g tissue) 0.05 ± 0.004 0.31 ± 0.03* 0.04 ± 0.006 0.20 ± 0.004#
Hydroperoxides (mM/100 g of tissue) 737.12 ± 63.57 1115.18 ± 223.04* 599.56 ± 71.90 779.10 ± 100.92#
  1. Values are represented as mean ± SD, n = 6, p < 0.05, comparisons are made between * Group 1 versus Group 2; # Group 2 versus Group 4