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Table 2 Influence of curcumin on metabolizing enzymes, antioxidants and lipid peroxides in kidney of control and experimental rats

From: Multivariate analysis and molecular interaction of curcumin with PPARγ in high fructose diet induced insulin resistance in rats

Biochemical parameters Group 1 Group 2 Group 3 Group 4
Hexokinase (mM of glucose phosphorylated/h/mg protein) 4.67 ± 0.16 3.34 ± 0.18* 4.76 ± 0.13 5.62 ± 0.26#
Glucose 6-phosphatase (mM of inorganic phosphorous liberated/min/mg protein) 28.38 ± 1.72 46.27 ± 2.06* 26.58 ± 1.75 37.19 ± 2.53#
Fructose 1,6-bis phosphatase (mM of inorganic phosphorous liberated/h/mg protein) 11.26 ± 1.88 26.97 ± 2.21* 20.69 ± 1.37 18.91 ± 5.58#
Catalase (units/mg of protein) 58.55 ± 0.76 17.53 ± 1.64* 49.44 ± 0.91 70.42 ± 0.69#
Super oxide dismutase (units/mg protein) 1518.34 ± 8.72 678.73 ± 10.71* 1345.78 ± 16.94 1134.16 ± 11.86#
Glutathione peroxidase (units/mg protein) 169.20 ± 1.0 17.53 ± 1.0* 102.94 ± 1.95 124.07 ± 2.18#
Vitamin C (µM/mg of tissue) 1.80 ± 0.04 0.72 ± 0.06* 1.8 ± 0.04 1.27 ± 0.03#
Vitamin E (µM/mg of tissue) 4.03 ± 0.12 1.35 ± 0.04* 3.52 ± 0.05 2.63 ± 0.07#
Glutathione reductase (mg/100 g of tissue) 1.40 ± 0.01 0.40 ± 0.04* 1.36 ± 0.05 0.80 ± 0.01#
Thiobarbituric acid reactive substances (mM/100 g tissue) 0.14 ± 0.02 0.34 ± 0.02* 0.12 ± 0.01 0.08 ± 0.003#
Hydroperoxides (mM/100 g of tissue) 540.10 ± 10 1271.17 ± 354.15* 517.81 ± 46.55 640.24 ± 73.76#
  1. Values are represented as mean ± SD, n = 6, p < 0.05, Comparisons are made between * Group 1 versus group 2; # Group 2 versus Group 4